Results 121 to 130 of about 10,422 (209)

Effect of protein synthesis inhibitors on the function of the neuronal K-Cl cotransporter KCC2 [PDF]

, 2010
The Cl- and HCO3- electrochemical gradients across the plasma membrane dictate the electrical consequences of GABAA receptor (GABAAR) function and thereby play a significant role in neuronal GABA-mediated signalling. In adult pyramidal neurons, responses
Puskarjov, Martin
core  

Astrocytic NKCC1 inhibits seizures by buffering Cl− and antagonizing neuronal NKCC1 at GABAergic synapses

Astrocytic NKCC1 inhibits seizures by buffering Cl− and antagonizing neuronal NKCC1 at GABAergic synapses
doctoral ...
openaire   +1 more source

Levels of Ca\u3csub\u3ev\u3c/sub\u3e1.2 L-Type Ca\u3csup\u3e2+\u3c/sup\u3e Channels Peak in the First Two Weeks in Rat Hippocampus Whereas Ca\u3csub\u3ev\u3c/sub\u3e1.3 Channels Steadily Increase through Development [PDF]

, 2012
Influx of calcium through voltage-dependent channels regulates processes throughout the nervous system. Specifically, influx through L-type channels plays a variety of roles in early neuronal development and is commonly modulated by G-protein-coupled ...
Ingraham, Nicholas E., Kramer, Audra A., Mynlieff, Michelle, Sharpe, Emily J.   +3 more
core   +1 more source

Generation and Characterization of the Cation-Chloride Cotransporter KCC2 Hypomorphic Mouse [PDF]

, 2006
The cation-Cl- cotransporter (CCC) family comprises of Na+-Cl- cotransporter (NCC), Na+-K+-2Cl- cotransporters (NKCC1-2), and four K+-Cl- cotransporters (KCC1-4).
Tornberg, Janne
core  

Structure and Function of the Transporter NKCC1 [PDF]

Biophysical Journal, 2018
Corinne Portioli, Marco De Vivo, Ming Zhou, Laura Cancedda   +3 more
openaire   +1 more source

Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]

, 2011
GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Crunelli, Vincenzo, Di Giovanni, Giuseppe, Errington, Adam C.   +2 more
core  

Isoflurane-induced neuroinflammation and NKCC1/KCC2 dysregulation result in long-term cognitive disorder in neonatal mice

BMC Anesthesiology
Background The inhalational anesthetic isoflurane is commonly utilized in clinical practice, particularly in the field of pediatric anesthesia. Research has demonstrated its capacity to induce neuroinflammation and long-term behavioral disorders; however,
Dongni Xu, Jiayi Liu, Shiyu Meng, Meixian Sun, Yuqing Chen, Yu Hong   +5 more
doaj   +1 more source

General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt [PDF]

, 2017
Background The developmental transition from depolarizing to hyperpolarizing γ-aminobutyric acid-mediated neurotransmission is primarily mediated by an increase in the amount of the potassium-chloride cotransporter KCC2 during early postnatal life ...
Bodogan, T., Fiumelli, H., Hemmings, H. C., Hemmings, H. C., Kaila, K., Lacoh, C.-M, Vutskits, L.   +6 more
core  

Chasing the ghost in the code: highlighting the mystery of a rare genetic condition. [PDF]

Am J Physiol Cell Physiol
Delpire E.
europepmc   +1 more source

Chloride Homeostasis Failure in Human Disease: KCC2/NKCC1 Microdomain Dysfunction as a Driver of Cortical Network Collapse. [PDF]

Int J Mol Sci
Dumitrescu D, Oprea S, Tulin R, Dumitru AV, Munteanu O, Pariza G.   +5 more
europepmc   +1 more source