Results 1 to 10 of about 175 (174)

Research progress of single nucleotide polymorphisms and immune cells in diabetic kidney disease [PDF]

Jichu yixue yu linchuang, 2022
Diabetic kidney disease has obvious family aggregation and ethnic differences, some single nucleotide polymorphisms (SNPs) related to the susceptibility of diabetic kidney disease have been identified, especially engulfment and cell motility 1 (ELMO1 ...
GUO Meng-ran, MIN Hang, YE Yue, XU Xiao-shuang, ZHEN Dong-hu
doaj   +1 more source

NKCC1 involvement in the epithelial-to-mesenchymal transition is a prognostic biomarker in gliomas [PDF]

PeerJ, 2020
Background Gliomas are the most prevalent type of intracranial tumors. NKCC1 is an important regulator in tumor cell volume. We noticed that abnormally high NKCC1 expression resulted in changes in the shape and adhesion of glioma cells.
Huaiyu Sun, Shengrong Long, Bingbing Wu, Jia Liu, Guangyu Li   +4 more
doaj   +2 more sources

Identification of key genes and validation of key gene aquaporin 1 on Wilms’ tumor metastasis [PDF]

PeerJ, 2023
Background Wilms’ tumor (WT) is one of the most common solid tumors in children with unsatisfactory prognosis, but few molecular prognostic markers have been discovered for it. Many genes are associated with the occurrence and prognosis of WT. This study
Hong Liu, Chen Jin, Xia Yang, Nan Xia, Chunzhi Guo, Qian Dong   +5 more
doaj   +2 more sources

Feeding rumen-protected lysine altered immune and metabolic biomarkers in dairy cows during the transition period

Journal of Dairy Science, 2023
: This experiment was conducted to determine the effects of feeding rumen-protected lysine (RPL; AjiPro-L Generation 3, Ajinomoto Health and Nutrition North America Inc.) from −26 ± 4.6 d prepartum (0.54% RPL of dietary dry matter intake) to 28 d ...
L.K. Fehlberg, A.R. Guadagnin, B.L. Thomas, M. Ballou, J.J. Loor, Y. Sugimoto, I. Shinzato, F.C. Cardoso   +7 more
doaj   +1 more source

Genetic and Biological Effects of SLC12A3, a Sodium-Chloride Cotransporter, in Gitelman Syndrome and Diabetic Kidney Disease

Frontiers in Genetics, 2022
The SLC12A3 (Solute carrier family 12 member 3) gene encodes a sodium-chloride cotransporter and mediates Na+ and Cl− reabsorption in the distal convoluted tubule of kidneys.
Nan Li, Harvest F. Gu
doaj   +1 more source

Hematopoietic Cell-Specific SLC37A2 Deficiency Accelerates Atherosclerosis in LDL Receptor-Deficient Mice

Frontiers in Cardiovascular Medicine, 2021
Macrophages play a central role in the pathogenesis of atherosclerosis. Our previous study demonstrated that solute carrier family 37 member 2 (SLC37A2), an endoplasmic reticulum-anchored phosphate-linked glucose-6-phosphate transporter, negatively ...
Qingxia Zhao, Zhan Wang, Allison K. Meyers, Jennifer Madenspacher, Manal Zabalawi, Qianyi Zhang, Elena Boudyguina, Fang-Chi Hsu, Charles E. McCall, Charles E. McCall, Cristina M. Furdui, John S. Parks, Michael B. Fessler, Xuewei Zhu, Xuewei Zhu   +14 more
doaj   +1 more source

SLC12A3 Variation and Renal Function in Chinese Patients With Hypertension

Frontiers in Medicine, 2022
ObjectiveSLC12A3 (solute carrier family 12 member 3) gene variants are associated with diabetic nephropathy; however, their association with hypertensive nephropathy remains unknown.
Chin-Chou Huang, Chin-Chou Huang, Chin-Chou Huang, Chin-Chou Huang, Chia-Min Chung, Chia-Min Chung, Chih-Yu Yang, Chih-Yu Yang, Chih-Yu Yang, Hsin-Bang Leu, Hsin-Bang Leu, Hsin-Bang Leu, Hsin-Bang Leu, Po-Hsun Huang, Po-Hsun Huang, Po-Hsun Huang, Po-Hsun Huang, Liang-Yu Lin, Liang-Yu Lin, Liang-Yu Lin, Tao-Cheng Wu, Tao-Cheng Wu, Tao-Cheng Wu, Shing-Jong Lin, Shing-Jong Lin, Shing-Jong Lin, Shing-Jong Lin, Wen-Harn Pan, Wen-Harn Pan, Jaw-Wen Chen, Jaw-Wen Chen, Jaw-Wen Chen, Jaw-Wen Chen   +32 more
doaj   +1 more source

Multi-omics assessment of dilated cardiomyopathy using non-negative matrix factorization.

PLoS ONE, 2022
Dilated cardiomyopathy (DCM), a myocardial disease, is heterogeneous and often results in heart failure and sudden cardiac death. Unavailability of cardiac tissue has hindered the comprehensive exploration of gene regulatory networks and nodal players in
Rewati Tappu, Jan Haas, David H Lehmann, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Andreas Keller, Hugo A Katus, Norbert Frey, Benjamin Meder   +8 more
doaj   +1 more source

Single-nucleotide polymorphism profiling by multimodal-targeted next-generation sequencing in methotrexate-resistant and -sensitive human osteosarcoma cell lines

Frontiers in Pharmacology, 2023
Introduction: Methotrexate (MTX) is one of the most important drugs included in the first-line protocols to treat high-grade osteosarcoma (HGOS). Although several polymorphisms have been reported to be associated with drug response or MTX-related ...
Chiara Casotti, Chiara Casotti, Claudia Maria Hattinger, Maria Pia Patrizio, Silvia Luppi, Leonardo Fantoni, Leonardo Fantoni, Michela Pasello, Katia Scotlandi, Toni Ibrahim, Massimo Serra   +10 more
doaj   +1 more source

The expression pattern of pyroptosis-related genes predicts the prognosis and drug response of melanoma

Scientific Reports, 2022
Cutaneous melanoma (CM, hereafter referred to as melanoma) is a highly malignant tumor that typically undergoes early metastasis. Pyroptosis, as a special programmed cell death process that releases inflammatory factors and has been widely studied in ...
Bin Zhou, Shanshan Sha, Juan Tao, Jun Li, Chen Shen, Jinjin Zhu, Lulu Tan, Liyun Dong, Changzheng Huang   +8 more
doaj   +1 more source