Results 11 to 20 of about 175 (174)

Solute Carrier Family 12 Member 2 as a Proteomic and Histological Biomarker of Dysplasia and Neoplasia in Ulcerative Colitis [PDF]

Journal of Crohn's and Colitis, 2020
Abstract Background and Aims Ulcerative colitis [UC] patients have a greater risk of developing colorectal cancer through inflammation-dysplasia-carcinoma sequence of transformation. The histopathological diagnosis of dysplasia is therefore of critical clinical relevance, but dysplasia may be ...
Merli, Angela-Maria, Vieujean, Sophie, MASSOT, Charlotte, BLETARD, Noëlla, QUESADA CALVO, Florence, Baiwir, Dominique, Mazzucchelli, Gabriel, Servais, Laurence, Wéra, Odile, Oury, Cécile, de Leval, Laurence, Sempoux, Christine, Manzini, Roberto, Bluemel, Sena, Scharl, Michael, Rogler, Gerhard, De Pauw, Edwin, COIMBRA MARQUES, Carla, Colard, Arnaud, Vijverman, Anne, Delvenne, Philippe, Louis, Edouard, Meuwis, Marie-Alice   +22 more
openaire   +4 more sources

Polymorphism of the solute carrier family 12 (sodium/chloride transporters) member 3, SLC12A3, gene at exon 23 (+78G/A: Arg913Gln) is associated with elevation of urinary albumin excretion in Japanese patients with type 2 diabetes: a 10-year longitudinal study [PDF]

Diabetologia, 2005
We have shown previously that the SLC12A3 +78G/A polymorphism in exon 23 (Arg913Gln) was a new candidate for conferring susceptibility to diabetic nephropathy. The aim of this study was to confirm the effect of this polymorphism on the elevation of urinary albumin excretion in type 2 diabetic patients.We retrospectively studied 264 Japanese patients ...
K, Nishiyama, Y, Tanaka, K, Nakajima, A, Mokubo, Y, Atsumi, K, Matsuoka, H, Watada, T, Hirose, T, Nomiyama, S, Maeda, R, Kawamori   +10 more
openaire   +2 more sources

Functions of the Thyroid-Stimulating Hormone on Key Developmental Features Revealed in a Series of Zebrafish Dyshormonogenesis Models

Cells, 2021
The hypothalamic–pituitary–thyroid (HPT) axis regulates many critical features in vertebrates. Utilizing TALENs and CRISPR/Cas9 techniques, thyroid-stimulating hormone subunit beta a (tshba), thyroglobulin (tg), and solute carrier family 16 member 2 ...
Jia Song, Yao Lu, Xiaoxia Cheng, Chuang Shi, Qiyong Lou, Xia Jin, Jiangyan He, Gang Zhai, Zhan Yin   +8 more
doaj   +1 more source

Targeting SCAMP2 by a natural product auxarconjugatin B for glioblastoma therapy via restoring aspartate metabolic flux

Acta Pharmaceutica Sinica B
Glioblastoma (GBM), the most aggressive primary brain malignancy, presents an urgent need for novel therapeutic targets addressing metabolic reprogramming in tumor progression.
Changhui Shang, Wan Li, Qianlun Pu, Bingyu Liu, Chen Zhang, Yiqing Tan, Yihui Yang, Dan Du, Jinhua Wang, Youcai Hu   +9 more
doaj   +1 more source

Placental imprinting of SLC22A3 in the IGF2R imprinted domain is conserved in therian mammals

Epigenetics & Chromatin, 2022
Background The eutherian IGF2R imprinted domain is regulated by an antisense long non-coding RNA, Airn, which is expressed from a differentially methylated region (DMR) in mice.
Teruhito Ishihara, Oliver W. Griffith, Shunsuke Suzuki, Marilyn B. Renfree   +3 more
doaj   +1 more source

Characterization of Genomic Variants Associated with Scout and Recruit Behavioral Castes in Honey Bees Using Whole-Genome Sequencing. [PDF]

PLoS ONE, 2016
Among forager honey bees, scouts seek new resources and return to the colony, enlisting recruits to collect these resources. Differentially expressed genes between these behaviors and genetic variability in scouting phenotypes have been reported.
Bruce R Southey, Ping Zhu, Morgan K Carr-Markell, Zhengzheng S Liang, Amro Zayed, Ruiqiang Li, Gene E Robinson, Sandra L Rodriguez-Zas   +7 more
doaj   +1 more source

Spatiotemporal expression and molecular regulation of calcium transport-related genes in the uterus of ducks during the egg-laying cycle

Poultry Science
This study investigated the molecular regulation of uterine calcium ion (Ca²⁺) transport during the oviposition cycle in Guizhou Sansui ducks. Uterine tissues were collected at 0, 2, 5, and 16 h after oviposition to determine Ca²⁺ concentrations and ...
Yong Zhao, Chaomei Liao, Hongmei Fu, Yijie Ding, Xingchen Guo, Yiyu Zhang   +5 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Additional file 2: of A missense mutation in solute carrier family 12, member 1 (SLC12A1) causes hydrallantois in Japanese Black cattle

, 2016
Sex of affected fetuses. PCR products with 119Â bp and 216Â bp were amplified using the primer pairs for the Y chromosome and GAPDH, respectively. Lanes 1 to 9: affected fetuses; lanes 10 and 11: cows; and lanes 12 and 13: sires. M: 100 bp ladder marker. (PPTX 902Â kb)
Sasaki, Shinji, Kiyotoshi Hasegawa, Higashi, Tomoko, Suzuki, Yutaka, Sugano, Sumio, Yasuda, Yasuaki, Sugimoto, Yoshikazu   +6 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source