Results 41 to 50 of about 8,301 (197)
Cerebral Cortex, 2022 The Na-K-2Cl cotransporter NKCC1 is widely expressed in cells within and outside the brain. However, our understanding of its roles in brain functions throughout development, as well as in neuropsychiatric and neurological disorders, has been severely ...
Samu N. Kurki +10 more
semanticscholar +1 more source
NKCC1 cotransporters: keeping an ‘ion’ them
The Journal of Physiology, 2011 The sodium–potassium–chloride cotransporter NKCC1 has a track record of bringing the ions it is named after into the cell. But recently, scientists discovered that the cotransporter brings a substantial amount of water into the cell as well. In a recent issue of The Journal of Physiology, Hamann et al. (2010) analysed cell volumes of human pigmented
George, Perez-Trevino, Sébastien, Vidal
openaire +5 more sources
Upregulation of Spinal ASIC1 and NKCC1 Expression Contributes to Chronic Visceral Pain in Rats
Frontiers in Molecular Neuroscience, 2021 Aims: To determine whether acid-sensing ion channel 1 (ASIC1)–sodium-potassium-chloride cotransporter 1 (NKCC1) signaling pathway participates in chronic visceral pain of adult rats with neonatal maternal deprivation (NMD).Methods: Chronic visceral pain ...
Yong-Chang Li +6 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2020 Background & Aims: Infections resulting from intestinal yeast and bacteria affect a large number of patients with deficits in absorptive or secretory epithelial transport mechanisms.
Rainelli Koumangoye +3 more
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NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus [PDF]
Epilepsy Research, 2008 During postnatal development of the central nervous system (CNS), the response of GABA(A) receptors to its agonist undergoes maturation from depolarizing to hyperpolarizing. This switch in polarity is due to the developmental decrease of the intracellular Cl concentration in neurons.
Lei, Zhu +3 more
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Frontiers in Cell and Developmental Biology, 2019 Hypoxic-ischemic encephalopathy (HIE) is a serious birth complication with severe long-term sequelae such as cerebral palsy, epilepsy and cognitive disabilities. Na+-K+-2Cl– cotransporters 1 (NKCC1) is dramatically upregulated after hypoxia-ischemia (HI),
Xing-Liang Yang +10 more
doaj +1 more source
The apical NKCC1 cotransporter debate
The FASEB Journal, 2012 Choroid plexus epithelial cells (CPECs) secrete cerebrospinal fluid (CSF) and regulate its electrolyte composition. CPECs express Na + /K + ATPase and Na + ‐K + ‐2Cl
Crum, Jeannine Marie +2 more
openaire +2 more sources
Frontiers in Physiology, 2020 Introduction: Na+-K+-2Cl− cotransporter isoform 1 (NKCC1) is important in regulating intracellular K+ and Cl− homeostasis and cell volume. In this study, we investigated a role of NKCC1 in regulating glioma K+ influx and proliferation in response to ...
Lanxin Luo +14 more
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Fluids and Barriers of the CNS, 2022 A range of neurological pathologies may lead to secondary hydrocephalus. Treatment has largely been limited to surgical cerebrospinal fluid (CSF) diversion, as specific and efficient pharmacological options are lacking, partly due to the elusive ...
T. Toft-Bertelsen +11 more
semanticscholar +1 more source
Neurobiology of Disease, 2021 Increased neuronal expression of the Na-K-2Cl cotransporter NKCC1 has been implicated in the generation of seizures and epilepsy. However, conclusions from studies on the NKCC1-specific inhibitor, bumetanide, are equivocal, which is a consequence of the ...
Philip Hampel +11 more
doaj +1 more source