Results 41 to 50 of about 7,960 (193)

In silico identification of potential inhibitors with higher potency than bumetanide targeting NKCC1: An important ion co-transporter to treat neurological disorders

Informatics in Medicine Unlocked, 2021
Na + -K + -2Cl-cotransporter 1 (NKCC1) plays an important role in intracellular ionic homeostasis and cell volume regulation in the brain. Pathological activation of brain NKCC1 is associated with many brain disorders, including ischemic stroke ...
Arpita Singha Roy, Md Sad Salabi Sawrav, Md Shahadat Hossain, Fatema Tuz Johura, Sk. Faisal Ahmed, Ithmam Hami, Md Kobirul Islam, Hasan Al Reza, Mohammad Iqbal H. Bhuiyan, Newaz Mohammed Bahadur, Md Mizanur Rahaman   +10 more
doaj   +1 more source

Inhibition of NKCC1 in spinal dorsal horn and dorsal root ganglion results in alleviation of neuropathic pain in rats with spinal cord contusion

Molecular Pain, 2023
Previous studies have confirmed the relationship between chloride homeostasis and pain. However, the role of sodium potassium chloride co-transporter isoform 1 (NKCC1) in dorsal horn and dorsal root ganglion neurons (DRGs) in spinal cord injury (SCI ...
Yao Wu, Fangyong Wang
doaj   +1 more source

Lack of NHE6 and Inhibition of NKCC1 Associated With Increased Permeability in Blood Labyrinth Barrier-Derived Endothelial Cell Layer. [PDF]

, 2022
Acoustic trauma, autoimmune inner ear disease, and presbycusis feature loss of the integrity of the blood-labyrinth barrier (BLB). Normal BLB function depends on endothelial structural integrity, which is supported and maintained by tight junctions and ...
Albano, Giuseppe, Bodmer, Daniel, Sgambato, Cinzia, Petkovic, Vesna, Sekulic-Jablanovic, Marijana, Paproth, Jessica, Fuster, Daniel G   +6 more
core   +2 more sources

NKCC1 Does Not Accumulate Chloride in Developing Retinal Neurons [PDF]

Journal of Neurophysiology, 2007
GABA excites immature neurons due to their relatively high intracellular chloride concentration. This initial high concentration is commonly attributed to the ubiquitous chloride cotransporter NKCC1, which uses a sodium gradient to accumulate chloride. Here we tested this hypothesis in immature retinal amacrine and ganglion cells.
Ling-Li, Zhang, Eric, Delpire, Noga, Vardi   +2 more
openaire   +2 more sources

Differential Expression of Pancreatic Protein and Chemosensing Receptor mRNAs in NKCC1-null Intestine [PDF]

, 2016
AIM: To investigate the intestinal functions of the NKCC1 Na+-K+-2Cl cotransporter (SLC12a2 gene), differential mRNA expression changes in NKCC1-null intestine were analyzed.
Bradford, Emily M., Shull, Gary E., Vairamani, Kanimozhi   +2 more
core   +1 more source

Pretreatment with AQP4 and NKCC1 Inhibitors Concurrently Attenuated Spinal Cord Edema and Tissue Damage after Spinal Cord Injury in Rats

Frontiers in Physiology, 2018
Spinal cord injury (SCI) affects more than 2.5 million people worldwide. Spinal cord edema plays critical roles in the pathological progression of SCI.
Xiaodong Yan, Juanfang Liu, Xiji Wang, Wenhao Li, Jingyuan Chen, Honghui Sun   +5 more
doaj   +1 more source

Mice lacking NKCC1 have normal olfactory sensitivity [PDF]

Physiology & Behavior, 2008
When olfactory receptor neurons respond to odors, a depolarizing Cl(-) efflux is a substantial part of the response. This requires that the resting neuron accumulate Cl(-) against an electrochemical gradient. In isolated olfactory receptor neurons, the Na(+)+K(+)+2Cl(-) cotransporter NKCC1 is essential for Cl(-) accumulation.
Department of Psychology, University of Florida, Gainesville, FL 32611, United States ( host institution ), Smith, David W. ( author ), Thach, Sokunthirith ( author ), Marshall, Erika L. ( author ), Mendoza, Mary-Grace ( author ), Kleene, Steven J. ( author )   +5 more
openaire   +3 more sources

Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation.

PLoS Biology, 2012
Glioblastoma (GB) is a highly invasive and lethal brain tumor due to its universal recurrence. Although it has been suggested that the electroneutral Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1) can play a role in glioma cell migration, the precise mechanism
Tomas Garzon-Muvdi, Paula Schiapparelli, Colette ap Rhys, Hugo Guerrero-Cazares, Christopher Smith, Deok-Ho Kim, Lyonell Kone, Harrison Farber, Danielle Y Lee, Steven S An, Andre Levchenko, Alfredo Quiñones-Hinojosa   +11 more
doaj   +1 more source

Inhibition of the NKCC1/NF-κB Signaling Pathway Decreases Inflammation and Improves Brain Edema and Nerve Cell Apoptosis in an SBI Rat Model

Frontiers in Molecular Neuroscience, 2021
Surgical brain injury (SBI) triggers microglia to release numerous inflammatory factors, leading to brain edema and neurological dysfunction. Reducing neuroinflammation and protecting the blood-brain barrier (BBB) are key factors to improve the ...
Yating Gong, Muyao Wu, Jinchao Shen, Jiafeng Tang, Jie Li, Jianguo Xu, Baoqi Dang, Gang Chen   +7 more
doaj   +1 more source

SiRNA-mediated inhibition of Na+ -K+-2Cl- cotransporter (NKCC1) and regulatory volume increase in the chondrocyte cell line C-20/A4

, 2011
The Na+–K+–2Cl− cotransporter (NKCC1) is an essential membrane transporter and has been linked to the regulation of volume, matrix synthesis and bone growth in chondrocytes; the sole resident cell type of articular cartilage.
Qusous, A., Greenwell, Pamela, Kerrigan, Mark J.P., Greenwell, P., Ala Qusous, Geewan, Corinne S.V., Pamela Greenwell, Qusous, Ala, Corinne S. V. Geewan, Kerrigan, M.J.P., Geewan, C., Mark J. P. Kerrigan   +11 more
core   +1 more source