Results 41 to 50 of about 10,422 (209)
NKCC1 Does Not Accumulate Chloride in Developing Retinal Neurons [PDF]
Journal of Neurophysiology, 2007 GABA excites immature neurons due to their relatively high intracellular chloride concentration. This initial high concentration is commonly attributed to the ubiquitous chloride cotransporter NKCC1, which uses a sodium gradient to accumulate chloride. Here we tested this hypothesis in immature retinal amacrine and ganglion cells.
Ling-Li, Zhang +2 more
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Frontiers in Cellular Neuroscience, 2016 The proliferative pool of neural progenitor cells is maintained by exquisitely controlled mechanisms for cell cycle regulation. The Na-K-Cl cotransporter NKCC1 is important for regulating cell volume and the proliferation of different cell types in vitro.
Ana Cathia Magalhães +3 more
doaj +1 more source
Molecular Pain, 2023 Previous studies have confirmed the relationship between chloride homeostasis and pain. However, the role of sodium potassium chloride co-transporter isoform 1 (NKCC1) in dorsal horn and dorsal root ganglion neurons (DRGs) in spinal cord injury (SCI ...
Yao Wu, Fangyong Wang
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NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus [PDF]
Epilepsy Research, 2008 During postnatal development of the central nervous system (CNS), the response of GABA(A) receptors to its agonist undergoes maturation from depolarizing to hyperpolarizing. This switch in polarity is due to the developmental decrease of the intracellular Cl concentration in neurons.
Lei, Zhu +3 more
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NKCC1 downregulation induces hyperpolarizing shift of GABA responsiveness at near term fetal stages in rat cultured dorsal root ganglion neurons [PDF]
, 2015 GABA A receptor-mediated neurotransmission is greatly influenced by cation-chloride cotransporter activity during developmental stages. In embryonic neurons Na–K–2Cl (NKCC1) cotransporters mediate active chloride uptake, thus increasing the intracellular
Bosch, Ludo Van Den +3 more
core +1 more source
Progressive NKCC1-Dependent Neuronal Chloride Accumulation during Neonatal Seizures [PDF]
The Journal of Neuroscience, 2010 Seizures induce excitatory shifts in the reversal potential for GABAA-receptor-mediated responses, which may contribute to the intractability of electro-encephalographic seizures and preclude the efficacy of widely used GABAergic anticonvulsants such as phenobarbital.
Volodymyr I, Dzhala +9 more
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Frontiers in Physiology, 2018 Spinal cord injury (SCI) affects more than 2.5 million people worldwide. Spinal cord edema plays critical roles in the pathological progression of SCI.
Xiaodong Yan +5 more
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Frontiers in Molecular Neuroscience, 2021 Surgical brain injury (SBI) triggers microglia to release numerous inflammatory factors, leading to brain edema and neurological dysfunction. Reducing neuroinflammation and protecting the blood-brain barrier (BBB) are key factors to improve the ...
Yating Gong +7 more
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Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation.
PLoS Biology, 2012 Glioblastoma (GB) is a highly invasive and lethal brain tumor due to its universal recurrence. Although it has been suggested that the electroneutral Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1) can play a role in glioma cell migration, the precise mechanism
Tomas Garzon-Muvdi +11 more
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Beta-Amyloid (Aβ1-42) Increases the Expression of NKCC1 in the Mouse Hippocampus
Molecules, 2022 Alzheimer’s disease (AD) is a neurodegenerative disorder with an increasing need for developing disease-modifying treatments as current therapies only provide marginal symptomatic relief.
Patricia Lam +8 more
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