Results 21 to 30 of about 7,960 (193)
NKCC1 involvement in the epithelial-to-mesenchymal transition is a prognostic biomarker in gliomas [PDF]
PeerJ, 2020 Background Gliomas are the most prevalent type of intracranial tumors. NKCC1 is an important regulator in tumor cell volume. We noticed that abnormally high NKCC1 expression resulted in changes in the shape and adhesion of glioma cells.
Huaiyu Sun +4 more
doaj +2 more sources
Frontiers in Cellular Neuroscience, 2021 Background Our aim was to investigate the effects of the protein expression and the function of sodium, potassium, and chloride co-transporter (NKCC1) in the dorsal root ganglion (DRG) after activation of transient receptor potential vanilloid 1 receptor
Shi-Yu Deng +26 more
doaj +1 more source
The roles of sodium-potassium-chloride cotransporter isoform-1 in acute lung injury
Tzu Chi Medical Journal, 2022 Acute lung injury (ALI) is often characterized by severe lung inflammation and pulmonary edema with poor gas exchange and hypoxemia. Alveolar inflammation and water flooding are, in fact, notable features of ALI pathogenesis.
Po-Chun Hsieh +5 more
doaj +1 more source
Fluids and Barriers of the CNS, 2023 Regulation of the volume and electrolyte composition of the cerebrospinal fluid (CSF) is vital for brain development and function. The Na-K-Cl co-transporter NKCC1 in the choroid plexus (ChP) plays key roles in regulating CSF volume by co-transporting ...
Ryann M. Fame +3 more
doaj +1 more source
Structure and mechanism of the cation–chloride cotransporter NKCC1 [PDF]
Nature, 2019 Cation-chloride cotransporters (CCCs) mediate the electroneutral transport of chloride, potassium and/or sodium across the membrane. They have critical roles in regulating cell volume, controlling ion absorption and secretion across epithelia, and maintaining intracellular chloride homeostasis.
Wang, Amy +9 more
openaire +4 more sources
PLoS Biology, 2022 The NKCC1 ion transporter contributes to the pathophysiology of common neurological disorders, but its function in microglia, the main inflammatory cells of the brain, has remained unclear to date. Therefore, we generated a novel transgenic mouse line in
Krisztina Tóth +14 more
doaj +1 more source
CSF secretion is not altered by NKCC1 Nor TRPV4 antagonism in healthy rats
, 2021 Background: Cerebrospinal fluid (CSF) secretion can be targeted to reduce elevated intracranial pressure (ICP). Sodium-potassium-chloride cotransporter 1 (NKCC1) antagonism is used clinically. However, supporting evidence is limited.
Patabendige, A.
core +1 more source
NKCC1 cotransporters: keeping an ‘ion’ them
The Journal of Physiology, 2011 The sodium–potassium–chloride cotransporter NKCC1 has a track record of bringing the ions it is named after into the cell. But recently, scientists discovered that the cotransporter brings a substantial amount of water into the cell as well. In a recent issue of The Journal of Physiology, Hamann et al. (2010) analysed cell volumes of human pigmented
George, Perez-Trevino, Sébastien, Vidal
openaire +5 more sources
Frontiers in Neurology, 2023 BackgroundThe balance between the activity of the Na+/K+/Cl− cotransporter (NKCC1) that introduces Cl− into the cell and the K+/Cl− cotransporter (KCC2) that transports Cl− outside the cell is critical in determining the inhibitory or excitatory outcome ...
Juan-Manuel Bonet-Fernández +8 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2020 Background & Aims: Infections resulting from intestinal yeast and bacteria affect a large number of patients with deficits in absorptive or secretory epithelial transport mechanisms.
Rainelli Koumangoye +3 more
doaj +1 more source