Results 21 to 30 of about 10,422 (209)
PLoS Biology, 2022 The NKCC1 ion transporter contributes to the pathophysiology of common neurological disorders, but its function in microglia, the main inflammatory cells of the brain, has remained unclear to date. Therefore, we generated a novel transgenic mouse line in
Krisztina Tóth +14 more
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NKCC1 and KCC2: Structural insights into phospho-regulation
Frontiers in Molecular Neuroscience, 2022 Inhibitory neurotransmission plays a fundamental role in the central nervous system, with about 30–50% of synaptic connections being inhibitory. The action of both inhibitory neurotransmitter, gamma-aminobutyric-acid (GABA) and glycine, mainly relies on the intracellular Cl– concentration in neurons.
Anna-Maria Hartmann +4 more
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Frontiers in Neurology, 2023 BackgroundThe balance between the activity of the Na+/K+/Cl− cotransporter (NKCC1) that introduces Cl− into the cell and the K+/Cl− cotransporter (KCC2) that transports Cl− outside the cell is critical in determining the inhibitory or excitatory outcome ...
Juan-Manuel Bonet-Fernández +8 more
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Upregulation of Spinal ASIC1 and NKCC1 Expression Contributes to Chronic Visceral Pain in Rats
Frontiers in Molecular Neuroscience, 2021 Aims: To determine whether acid-sensing ion channel 1 (ASIC1)–sodium-potassium-chloride cotransporter 1 (NKCC1) signaling pathway participates in chronic visceral pain of adult rats with neonatal maternal deprivation (NMD).Methods: Chronic visceral pain ...
Yong-Chang Li +6 more
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Brain Sciences, 2022 The time-sensitive GABA shift from excitatory to inhibitory is critical in early neural circuits development and depends upon developmentally regulated expression of cation-chloride cotransporters NKCC1 and KCC2.
Jacek Szymanski, Liliana Minichiello
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Cellular and Molecular Gastroenterology and Hepatology, 2020 Background & Aims: Infections resulting from intestinal yeast and bacteria affect a large number of patients with deficits in absorptive or secretory epithelial transport mechanisms.
Rainelli Koumangoye +3 more
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Frontiers in Cell and Developmental Biology, 2019 Hypoxic-ischemic encephalopathy (HIE) is a serious birth complication with severe long-term sequelae such as cerebral palsy, epilepsy and cognitive disabilities. Na+-K+-2Cl– cotransporters 1 (NKCC1) is dramatically upregulated after hypoxia-ischemia (HI),
Xing-Liang Yang +10 more
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Frontiers in Physiology, 2020 Introduction: Na+-K+-2Cl− cotransporter isoform 1 (NKCC1) is important in regulating intracellular K+ and Cl− homeostasis and cell volume. In this study, we investigated a role of NKCC1 in regulating glioma K+ influx and proliferation in response to ...
Lanxin Luo +14 more
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Cells, 2023 An upregulation of the Na+-K+-2Cl− cotransporter NKCC1, the main chloride importer in mature neurons, can lead to depolarizing/excitatory responses mediated by GABA type A receptors (GABAARs) and, thus, to hyperactivity.
Etienne Côme +4 more
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Versatility of NaCl transport mechanisms in the cortical collecting duct [PDF]
, 2017 Versatility of NaCl transport mechanisms in the cortical collecting duct. Am J Physiol Renal Physiol 313: F1254 –F1263, 2017. First published September 6, 2017; doi:10.1152/ajprenal.00369.2017.—The cortical collecting duct (CCD) forms part of the ...
Crambert, Gilles, Edwards, Aurelie
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