Results 41 to 50 of about 10,959 (212)
Molecular Autism, 2020 Background Tuberous sclerosis complex (TSC) is an autosomal dominant disease that affects multiple organs including the brain. TSC is strongly associated with broad neurodevelopmental disorders, including autism spectrum disorder symptomatology ...
Dorinde M. van Andel +5 more
doaj +1 more source
Pharmacotherapy for neonatal seizures: current knowledge and future perspectives [PDF]
, 2016 Seizures are the most common neurological emergencies in the neonatal period and are associated with poor neurodevelopmental outcomes. Seizures affect up to five per 1000 term births and population-based studies suggest that they occur even more ...
Boylan, Geraldine B. +4 more
core +1 more source
Neural Regeneration Research, 2016 Bumetanide has been shown to lessen cerebral edema and reduce the infarct area in the acute stage of cerebral ischemia. Few studies focus on the effects of bumetanide on neuroprotection and neurogenesis in the chronic stage of cerebral ischemia.
Wang-shu Xu +6 more
doaj +1 more source
Successful private–public funding of paediatric medicines research: lessons from the EU programme to fund research into off-patent medicines [PDF]
, 2014 The European Paediatric Regulation mandated the European Commission to fund research on off-patent medicines with demonstrated therapeutic interest for children.
Baiardi, P +17 more
core +1 more source
A Randomised Controlled Trial of Bumetanide in the Treatment of Autism in Children [PDF]
, 2013 Gamma aminobutyric acid (GABA)-mediated synapses and the oscillations they orchestrate are altered in autism. GABA-acting benzodiazepines exert in some patients with autism paradoxical effects, raising the possibility that like in epilepsies, GABA ...
Ben-Ari, Yehezkel +7 more
core +1 more source
Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers [PDF]
, 2018 Background & Aims: Human enteroids present a novel tool to study human intestinal ion transport physiology and pathophysiology. The present study describes the contributions of Cl- and HCO3 - secretion to total cyclic adenosine monophosphate (cAMP ...
Avula, L.R. (Leela Rani) +6 more
core +5 more sources
Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. [PDF]
, 2016 Electrical membrane properties of skeletal muscle fibers have been thoroughly studied over the last five to six decades. This has shown that muscle fibers from a wide range of species, including fish, amphibians, reptiles, birds, and mammals, are all ...
Chen, Tsung-Yu +4 more
core +1 more source
Cells, 2022 GABA depolarizes and often excites immature neurons in all animal species and brain structures investigated due to a developmentally regulated reduction in intracellular chloride concentration ([Cl−]i) levels.
Yehezkel Ben-Ari, Enrico Cherubini
doaj +1 more source
Бюллетень сибирской медицины, 2016 The aim of this study was to investigate the role of the Na+, K+, 2Cl– -transport and potassium conductance, in the implementation of the effects of carbon monoxide in the SMC taenia coli and ureter of guinea pig.Materials and methods.
A. V. Skvortsov +7 more
doaj +1 more source
A Hidden Culprit: Aldosteronoma as a Rare Cause of Refractory Hypertension in Autosomal‐Dominant Polycystic Kidney Disease [PDF]
Clin Case RepABSTRACT Hypertension is common in autosomal‐dominant polycystic kidney disease (ADPKD) but may occasionally reflect a secondary etiology. We report a 71‐year‐old man with ADPKD and end‐stage renal disease who developed persistent, refractory hypertension following renal transplantation despite multidrug therapy and bilateral native nephrectomy ...
Wainstein M +7 more
europepmc +2 more sources