Results 51 to 60 of about 10,959 (212)
Physiological levels of lipoxin A4 inhibit ENaC and restore airway surface liquid height in cystic fibrosis bronchial epithelium. [PDF]
, 2014 In cystic fibrosis (CF), the airway surface liquid (ASL) is depleted. We previously demonstrated that lipoxin A4 (LXA4) can modulate ASL height (ASLh) through actions on Cl(-) transport.
Al-Alawi, Mazen +8 more
core +5 more sources
Frontiers in Neuroscience, 2022 Neuronal excitation-inhibition (E/I) imbalances are considered an important pathophysiological mechanism in neurodevelopmental disorders. Preclinical studies on tuberous sclerosis complex (TSC), suggest that altered chloride homeostasis may impair ...
Erika L. Juarez-Martinez +13 more
doaj +1 more source
, 2015 As an intern, I thought of myself as the member of the team who gets the things done. I took pride in prioritizing my long list of tasks and efficiently working through each item.
Alloo Hong, MD, Jennifer
core +4 more sources
Bumetanide As a Candidate Treatment for Behavioral Problems in Tuberous Sclerosis Complex
Frontiers in Neurology, 2017 BackgroundRecent studies indicate excitatory GABA action in and around tubers in patients with tuberous sclerosis complex (TSC). This may contribute to recurrent seizures and behavioral problems that may be treated by agents that enhance GABAergic ...
Chantal Vlaskamp +6 more
doaj +1 more source
Developmental Dynamics, EarlyView.Abstract Background Previous experiments inducing leakage of embryonic cerebrospinal fluid (CSF) suggest the necessity of intraventricular CSF pressure (PCSF) for brain morphogenesis. Nevertheless, how embryonic PCSF occurs is unclear, especially in utero. Results Using a Landis water manometer, we measured PCSF in fetal mice isolated from the amniotic
Koichiro Tsujikawa +2 more
wiley +1 more source
Food: An Unrecognized Source of Loop Diuretic Resistance [PDF]
, 2004 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90131/1/phco.24.6.630.34736 ...
Bard, Robert L. +2 more
core +1 more source
Neonatal seizures and GABAergic drugs: Scylla and Charybdis?
Epilepsia Open, EarlyView.Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson +2 more
wiley +1 more source
A Case Report of a Special Type of Multiple Myeloma: Kappa Light Chain‐Only
Organ Medicine, EarlyView.This case illustrates the clinical course of a patient diagnosed with kappa light chain‐only multiple myeloma, a rare subtype of multiple myeloma. Of note, light chain multiple myeloma is characterized by rapid disease progression and severe target organ damage.
Yanhua Dai +8 more
wiley +1 more source
Effects of therapeutic hypothermia on white matter injury from murine neonatal hypoxia-ischemia. [PDF]
, 2017 BackgroundTherapeutic hypothermia (TH) is the standard of care for neonates with hypoxic-ischemic encephalopathy, but it is not fully protective in the clinical setting.
Ferriero, Donna M +4 more
core +2 more sources
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu +4 more
wiley +1 more source