Results 31 to 40 of about 8,274 (202)

Novel Pharmaceutical Cocrystals and Salts of Bumetanide

, 2019
New crystalline forms of bumetanide, namely, four cocrystals, two salts, and one salt-cocrystal were crystallized. Urea and lactams such as valerolactam, caprolactam, and N-methyl caprolactam formed cocrystals with bumetanide, whereas 4-aminopyridine ...
Ashwini K. Nangia (7148528), Srinu Tothadi (1744144), Suryanarayana Allu (1605856), Geetha Bolla (1744141)   +3 more
core   +1 more source

Application of a physiologically-based pharmacokinetic model for the prediction of bumetanide plasma and brain concentrations in the neonate [PDF]

, 2020
Bumetanide is a loop diuretic that is proposed to possess a beneficial effect on disorders of the central nervous system, including neonatal seizures.
Donovan, Maria D., Abduljalil, Khaled, Griffin, Brendan T., Boylan, Geraldine B., Cryan, John F.   +4 more
core   +1 more source

ROLE OF Na+, K+, 2Cl– -COTRANSPORTER AND POTASSIUM CONDUCTIVITY IN THE REALIZATION OF THE EFFECT OF CARBON MONOXIDE, IN THE SMOOTH MUSCLE OF VISCERAL ORGANS

Бюллетень сибирской медицины, 2016
The aim of this study was to investigate the role of the Na+, K+, 2Cl– -transport and potassium conductance, in the implementation of the effects of carbon monoxide in the SMC taenia coli and ureter of guinea pig.Materials and methods.
A. V. Skvortsov, M. A. Medvedev, V. B. Studnitsky, I. V. Kovalev, Y. A. Pogudin, S. V. Gusakova, O. I. Antonov, J. G. Birulina   +7 more
doaj   +1 more source

Bumetanide Effects on Resting-State EEG in Tuberous Sclerosis Complex in Relation to Clinical Outcome: An Open-Label Study

Frontiers in Neuroscience, 2022
Neuronal excitation-inhibition (E/I) imbalances are considered an important pathophysiological mechanism in neurodevelopmental disorders. Preclinical studies on tuberous sclerosis complex (TSC), suggest that altered chloride homeostasis may impair ...
Erika L. Juarez-Martinez, Erika L. Juarez-Martinez, Dorinde M. van Andel, Jan J. Sprengers, Arthur-Ervin Avramiea, Bob Oranje, Floortje E. Scheepers, Floor E. Jansen, Huibert D. Mansvelder, Klaus Linkenkaer-Hansen, Hilgo Bruining, Hilgo Bruining, Hilgo Bruining, Hilgo Bruining   +13 more
doaj   +1 more source

Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex: an open-label pilot study

Molecular Autism, 2020
Background Tuberous sclerosis complex (TSC) is an autosomal dominant disease that affects multiple organs including the brain. TSC is strongly associated with broad neurodevelopmental disorders, including autism spectrum disorder symptomatology ...
Dorinde M. van Andel, Jan J. Sprengers, Bob Oranje, Floortje E. Scheepers, Floor E. Jansen, Hilgo Bruining   +5 more
doaj   +1 more source

The GABA Polarity Shift and Bumetanide Treatment: Making Sense Requires Unbiased and Undogmatic Analysis

Cells, 2022
GABA depolarizes and often excites immature neurons in all animal species and brain structures investigated due to a developmentally regulated reduction in intracellular chloride concentration ([Cl−]i) levels.
Yehezkel Ben-Ari, Enrico Cherubini
doaj   +1 more source

Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures.

PLoS ONE, 2013
Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na(+)-K(+)-2 Cl(-) cotransporter, NKCC1, and consequent paradoxical excitatory actions of GABAA ...
Ryan T Cleary, Hongyu Sun, Thanhthao Huynh, Simon M Manning, Yijun Li, Alexander Rotenberg, Delia M Talos, Kristopher T Kahle, Michele Jackson, Sanjay N Rakhade, Gerard T Berry, Frances E Jensen   +11 more
doaj   +1 more source

UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Reinhold Kreutz, Pimrapat Gebert, Jingwen Luo, Paraskevi Tassopoulou, Juliane Bolbrinker, Antonios Douros   +5 more
wiley   +1 more source

Bumetanide As a Candidate Treatment for Behavioral Problems in Tuberous Sclerosis Complex

Frontiers in Neurology, 2017
BackgroundRecent studies indicate excitatory GABA action in and around tubers in patients with tuberous sclerosis complex (TSC). This may contribute to recurrent seizures and behavioral problems that may be treated by agents that enhance GABAergic ...
Chantal Vlaskamp, Simon-Shlomo Poil, Floor Jansen, Klaus Linkenkaer-Hansen, Sarah Durston, Bob Oranje, Hilgo Bruining   +6 more
doaj   +1 more source

The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme

Pharmaceuticals, 2020
The membrane-bound human carbonic anhydrase (hCA) IX is widely recognized as a marker of tumor hypoxia and a prognostic factor within several human cancers. Being undetected in most normal tissues, hCA-IX implies the pharmacotherapeutic advent of reduced
Azizah M. Malebari, Tarek S. Ibrahim, Ibrahim M. Salem, Ismail Salama, Ahdab N. Khayyat, Samia M. Mostafa, Osama I. El-Sabbagh, Khaled M. Darwish   +7 more
doaj   +1 more source