Results 31 to 40 of about 10,959 (212)

A Wholistic View of How Bumetanide Attenuates Autism Spectrum Disorders

Cells, 2022
The specific NKCC1 cotransporter antagonist, bumetanide, attenuates the severity of Autism Spectrum Disorders (ASD), and many neurodevelopmental or neurodegenerative disorders in animal models and clinical trials.
Eric Delpire, Yehezkel Ben-Ari
doaj   +1 more source

Failure of bumetanide to improve outcome after intracerebral hemorrhage in rat.

PLoS ONE, 2019
After intracerebral hemorrhage (ICH), brain edema commonly occurs and can cause death. Along with edema, there are significant alterations in the concentrations of key ions such as sodium, potassium, and chloride, which are essential to brain function ...
Cassandra M Wilkinson, Brittany A Fedor, Jasmine R Aziz, Colby A Nadeau, Paul S Brar, Julia J A Clark, Frederick Colbourne   +6 more
doaj   +1 more source

Inhibition of NKCC1 attenuated hippocampal LTP formation and inhibitory avoidance in rat.

PLoS ONE, 2014
The loop diuretic bumetanide (Bumex) is thought to have antiepileptic properties via modulate GABAA mediated signaling through their antagonism of cation-chloride cotransporters.
Meng Chang Ko, Min Chong Lee, Tamara G Amstislavskaya, Maria A Tikhonova, Yi-Ling Yang, Kwok-Tung Lu   +5 more
doaj   +1 more source

Effect of the combination of bumetanide plus chlorthalidone on hypertension and volume overload in patients with chronic kidney disease stage 4–5 KDIGO without renal replacement therapy: a double-blind randomized HEBE-CKD trial

BMC Nephrology, 2022
Background The co-administration of loop diuretics with thiazide diuretics is a therapeutic strategy in patients with hypertension and volume overload.
Fabio Solis-Jimenez, Lucia Monserrat Perez-Navarro, Ricardo Cabrera-Barron, Jesus Antonio Chida-Romero, Geovana Martin-Alemañy, Edgar Dehesa-López, Magdalena Madero, Rafael Valdez-Ortiz   +7 more
doaj   +1 more source

Loop Diuretics Inhibit Ischemia-Induced Intracellular Ca2+ Overload in Neurons via the Inhibition of Voltage-Gated Ca2+ and Na+ Channels

Frontiers in Pharmacology, 2021
One consequence of ischemic stroke is disruption of intracellular ionic homeostasis. Intracellular overload of both Na+ and Ca2+ has been linked to neuronal death in this pathophysiological state.
Christopher Katnik, Javier Cuevas
doaj   +1 more source

Bumetanide for Irritability in Children With Sensory Processing Problems Across Neurodevelopmental Disorders: A Pilot Randomized Controlled Trial

Frontiers in Psychiatry, 2022
BackgroundTreatment development for neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) is impeded by heterogeneity in clinical manifestation and underlying etiologies.
Dorinde M. van Andel, Jan J. Sprengers, Mandy G. Keijzer-Veen, Annelien J. A. Schulp, Marc R. Lillien, Floortje E. Scheepers, Hilgo Bruining   +6 more
doaj   +1 more source

Drug-induced stress granule formation protects sensory hair cells in mouse cochlear explants during ototoxicity [PDF]

, 2019
Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative disease.
Dawson, Sally J., Gale, Jonathan E., Gonçalves, Ana Cláudia, Haq, Naila, Pelletier, Jerry, Porco, John A., Towers, Emily R.   +6 more
core   +2 more sources

Expression and effect of sodium-potassium-chloride cotransporter on dorsal root ganglion neurons in a rat model of chronic constriction injury

Neural Regeneration Research, 2020
Sodium-potassium-chloride cotransporter 1 (NKCC1) and potassium-chloride cotransporter 2 (KCC2) are associated with the transmission of peripheral pain.
Chao-Yang Tan, Yan-Ping Wang, Yuan-Yuan Han, Bi-Han Lu, Wei Ji, Li-Cang Zhu, Yang Wang, Wen-Yan Shi, Li-Ya Shan, Liang Zhang, Ke-Tao Ma, Li Li, Jun-Qiang Si   +12 more
doaj   +1 more source

Long-term administration of bumetanide improve functional recovery after spinal cord injury in rats

Frontiers in Pharmacology, 2022
Ion disturbances are among the most remarkable deficits in spinal cord injury (SCI). GABA is an integral part of neural interaction. Action of the GABAA receptor depends on the amount of intracellular chloride.
Shiva Hashemizadeh, Shiva Hashemizadeh, Zeinab Gharaylou, Saereh Hosseindoost, Saereh Hosseindoost, Maryam Sardari, Ameneh Omidi, Hassan Hosseini ravandi, Mahmoudreza Hadjighassem, Mahmoudreza Hadjighassem   +9 more
doaj   +1 more source

Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures [PDF]

, 2014
Seizures are a common manifestation of acute neurologic insults in neonates and are often resistant to the standard antiepileptic drugs that are efficacious in children and adults.
Delpire E, Goda S, Kaila K, Mares P, Randall J, Soul J, Volpe J, Walker PC   +7 more
core   +1 more source