Results 71 to 80 of about 10,959 (212)

NKCC1 downregulation induces hyperpolarizing shift of GABA responsiveness at near term fetal stages in rat cultured dorsal root ganglion neurons [PDF]

, 2015
GABA A receptor-mediated neurotransmission is greatly influenced by cation-chloride cotransporter activity during developmental stages. In embryonic neurons Na–K–2Cl (NKCC1) cotransporters mediate active chloride uptake, thus increasing the intracellular
Bosch, Ludo Van Den, Callewaert, Geert, Chabwine, Joelle N, Talavera, Karel   +3 more
core   +1 more source

Real‐World Effectiveness of Tolvaptan for Hyponatremia in Cirrhosis Across Global Regions: A Target Trial Emulation

JGH Open, Volume 10, Issue 4, April 2026.
ABSTRACT Background Tolvaptan promotes electrolyte‐free water excretion and is widely used in Asia for ascites, but in Western countries its use is limited to hyponatremia because of hepatotoxicity concerns. Methods We performed a retrospective cohort study using the TriNetX Research Network, emulating a target trial of cirrhotic patients with ...
Kazuya Okushin, Ryosuke Tateishi, Mitsuhiro Fujishiro, Takeya Tsutsumi, Kazuhiko Koike, Tomohiro Tanaka   +5 more
wiley   +1 more source

Recovery from acidosis is a robust trigger for loss of force in murine hypokalemic periodic paralysis. [PDF]

, 2019
Periodic paralysis is an ion channelopathy of skeletal muscle in which recurrent episodes of weakness or paralysis are caused by sustained depolarization of the resting potential and thus reduction of fiber excitability.
Cannon, Stephen C, DiFranco, Marino, Mi, Wentao, Quinonez, Marbella, Wu, Fenfen   +4 more
core   +1 more source

Druggable genome‐wide Mendelian randomization analysis identifies potential treatment targets in vascular dementia

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract BACKGROUND There are currently no US Food and Drug Administration‐approved treatments for vascular dementia (VaD). Genome‐wide approaches have successfully identified druggable targets and treatments for various disorders. In this study, we performed druggable genome‐wide two‐sample Mendelian randomization (2SMR) analysis to identify possible ...
Matthew J. Lennon, Ying Xu, Anbupalam Thalamuthu, Karen Mather, Perminder S. Sachdev   +4 more
wiley   +1 more source

Seasonal relapsing minimal change disease: a novel strategy for avoiding long-term immunosuppression. [PDF]

, 2012
BACKGROUND: We describe the case of a young woman with seasonal allergic rhinitis who presented with signs of a lower respiratory tract infection, acute renal impairment and the nephrotic syndrome, demonstrated on biopsy to be due to minimal change ...
Cook, HT, Lawrence, C, Lightstone, L
core   +2 more sources

Regulation of Choroid Plexus Bicarbonate Transporters Following Intraventricular Hemorrhage in Mice

Cell Biochemistry and Function, Volume 44, Issue 3, March 2026.
ABSTRACT Posthemorrhagic hydrocephalus is a severe complication to intraventricular hemorrhage. The condition results in enlarged brain ventricles and increased intracranial pressure due to accumulation of cerebrospinal fluid (CSF). In this study, two mouse models of intraventricular hemorrhage were investigated: injection of lysed red blood cells ...
Laura Øllegaard Johnsen, Rasmus Herløw, Rasmus West Knopper, Thomas Beck Lindhardt, Brian Hansen, Helle Hasager Damkier   +5 more
wiley   +1 more source

Effects of 5-hydroxymethyl-2-furfural on the volume and membrane permeability of red blood cells from patients with sickle cell disease. [PDF]

, 2014
The heterocyclic aldehyde 5-hydroxymethyl-2-furfural (5HMF) interacts allosterically with the abnormal form of haemoglobin (Hb), HbS, in red blood cells (RBCs) from patients with sickle cell disease (SCD), thereby increasing oxygen affinity and ...
Cytlak, Urszula M, Gibson, John S, Hannemann, Anke, Rees, David C, Tewari, Sanjay   +4 more
core   +2 more sources

Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption [PDF]

, 2020
The epithelial sodium channel (ENaC) can increase the colonic absorptive capacity for salt and water. Campylobacter concisus is a common pathogenic epsilonproteobacterium, causing enteritis and diarrhea. It can induce barrier dysfunction in the intestine,
Bereswill, Stefan, Butkevych, Eduard, Bücker, Roland, Fromm, Anja, Genger, Claudia, Heimesaat, Markus M., Kløve, Sigri, Lee, In-Fah Maria, Lobo de Sá, Fábia Daniela, Mousavi, Soraya, Nagel, Oliver, Nattramilarasu, Praveen Kumar, Nielsen, Hans Linde, Schulzke, Jörg-Dieter, Schweiger, Michal R., Troeger, Hanno   +15 more
core   +2 more sources

Adjusting the Preincubation Conditions to Enhance the Ames Test for Detecting the Mutagenicity of N‐Nitrosamines

Environmental and Molecular Mutagenesis, Volume 67, Issue 3, March 2026.
ABSTRACT Conducting S9‐mediated preincubations at slightly acid pHs (e.g., pH 5.0 to pH 6.5) has been reported to enhance the mutagenicity of small‐molecule nitrosamines in the Ames test. In this study, we have evaluated the effect of adjusting the preincubation mix used in the Enhanced Ames Test (EAT) from pH 7.4 to pH 6.0 and supplying the activation
Michelle E. Bishop, Audrey M. Sims, Sharon K. Guerrero, Kamela Mitchell, Nan Mei, Hannah Xu, Naomi L. Kruhlak, Sruthi T. King, Robert T. Dorsam, Aisar H. Atrakchi, Timothy J. McGovern, Robert H. Heflich   +11 more
wiley   +1 more source

Potassium channel and NKCC cotransporter involvement in ocular refractive control mechanisms. [PDF]

PLoS ONE, 2008
Myopia affects well over 30% of adult humans globally. However, the underlying physiological mechanism is little understood. This study tested the hypothesis that ocular growth and refractive compensation to optical defocus can be controlled by ...
Sheila G Crewther, Melanie J Murphy, David P Crewther   +2 more
doaj   +1 more source