Results 91 to 100 of about 8,546 (246)
Regulation of Choroid Plexus Bicarbonate Transporters Following Intraventricular Hemorrhage in Mice
Cell Biochemistry and Function, Volume 44, Issue 3, March 2026.ABSTRACT Posthemorrhagic hydrocephalus is a severe complication to intraventricular hemorrhage. The condition results in enlarged brain ventricles and increased intracranial pressure due to accumulation of cerebrospinal fluid (CSF). In this study, two mouse models of intraventricular hemorrhage were investigated: injection of lysed red blood cells ...
Laura Øllegaard Johnsen +5 more
wiley +1 more source
, 2016 The Na(+)-K(+)-Cl(-) cotransporter NKCC1 plays a major role in the regulation of intraneuronal Cl(-) concentration. Abnormal functionality of NKCC1 has been implicated in several brain disorders, including epilepsy.
Feit, Peter W +5 more
core +1 more source
Interaction of bumetanide derivatives with hepatocellular bile acid uptake
, 1993 The loop diuretic bumetanide is an organic monocarboxylic organic anion assumed to be transported into hepatocytes by a transport system for bile acids.
E. Petzinger +6 more
core +1 more source
INTERACTION OF BUMETANIDE AND KANAMYCIN
Nippon Jibiinkoka Gakkai Kaiho, 1978 In the present study, rabbits were treated with kanamycin in combination with a new loop diuretic bumetanide at a dosage level equipotent to the diuretic action of furosemide. Severe outer hair cell damage occurred in animals following the combined administration of bumetanide and kanamycin, and the damage was approximately equal to that of animals ...
OHTANI, IWAO +4 more
openaire +2 more sources
Environmental and Molecular Mutagenesis, Volume 67, Issue 3, March 2026.ABSTRACT Conducting S9‐mediated preincubations at slightly acid pHs (e.g., pH 5.0 to pH 6.5) has been reported to enhance the mutagenicity of small‐molecule nitrosamines in the Ames test. In this study, we have evaluated the effect of adjusting the preincubation mix used in the Enhanced Ames Test (EAT) from pH 7.4 to pH 6.0 and supplying the activation
Michelle E. Bishop +11 more
wiley +1 more source
The Pharmacokinetics And Pharmacodynamics Of Bumetanide (diuretics).
, 1985 Bumetanide is a potent loop diuretic that acts at the thick ascending limb of the loop of Henle where it inhibits solute reabsorption. Since bumetanide is highly bound to proteins, the drug gains access to the kidney lumen predominantly at the pars recta
Lau, Henry San Heng
core
Acta Physiologica, Volume 242, Issue 2, February 2026.ABSTRACT Background and Aims Colonic bicarbonate secretion is mediated by the chloride/bicarbonate exchanger SLC26A3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Dysfunction of either causes luminal acidosis, altered mucus properties, and inflammation.
Mahdi Amiri, Azam Salari, Ursula Seidler
wiley +1 more source
Scientific Reports, 2018 The Na+–K+–2Cl− cotransporter NKCC1 plays a role in neuronal Cl− homeostasis secretion and represents a target for brain pathologies with altered NKCC1 function. Two main variants of NKCC1 have been identified: a full-length NKCC1 transcript (NKCC1A) and
Philip Hampel +3 more
semanticscholar +1 more source
Systemic administration of bumetanide blocked inhibitory avoidance learning.
, 2016 (A) Rats were administered vehicle and bumetanide intravenously 1 hr prior to training session. The test was carried out 24 hrs later. Result showed that retention latency of the bumetanide-treated group was decreased significantly compared with vehicle ...
Tamara G. Amstislavskaya (598275) +5 more
core +1 more source
Pharmacoepidemiology evaluation of bumetanide as a potential candidate for drug repurposing for Alzheimers disease. [PDF]
INTRODUCTION: Bumetanide, a loop diuretic, was identified as a candidate drug for repurposing for Alzheimers disease (AD) based on its effects on transcriptomic apolipoprotein E signatures.
Natarajan, Loki +8 more
core +1 more source