Results 101 to 110 of about 10,959 (212)

Bumetanide increases Cl--dependent short-circuit current in late distal colon: Evidence for the presence of active electrogenic Cl- absorption.

PLoS ONE, 2017
Mammalian colonic epithelia consist of cells that are capable of both absorbing and secreting Cl-. The present studies employing Ussing chamber technique identified two opposing short-circuit current (Isc) responses to basolateral bumetanide in rat ...
Lieqi Tang, Xiefan Fang, Steven P Winesett, Catherine Y Cheng, Henry J Binder, Scott A Rivkees, Sam X Cheng   +6 more
doaj   +1 more source

Electrophysiological characteristics of cationic single-channel formed by incorporation of amphotericin b in bilayer lipid membrane [PDF]

, 2016
BACKGROUND AND OBJECTIVE: Amphotericin B (AmB) is the main antibiotic of polyene type, which is widely used in the treatment of systemic fungal infections.
Ashrafpour, M., Sepehri, H., Shahmoradi, T.   +2 more
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Hydroxyapatite Nanorods Based Drug Delivery Systems for Bumetanide and Meloxicam, Poorly Water Soluble Active Principles

Nanomaterials
Poorly water-soluble drugs represent a challenge for the pharmaceutical industry because it is necessary to find properly tuned and efficient systems for their release.
Valeria Friuli, Lauretta Maggi, Giovanna Bruni, Francesca Caso, Marcella Bini   +4 more
doaj   +1 more source

Bumetanide Therapeutic Effect in Children and Adolescents With Autism Spectrum Disorder: A Review Study

Basic and Clinical Neuroscience, 2019
Introduction: Autism Spectrum Disorder (ASD) is characterized by several impairments in communications and social interactions, as well as restricted interests or stereotyped behaviors.
Raheleh Mollajani, Mohamad Taghi Joghataei, Mehdi Tehrani-doost   +2 more
doaj  

Exit interviews from two randomised placebo-controlled phase 3 studies with caregivers of young children with autism spectrum disorder

Frontiers in Child and Adolescent Psychiatry
IntroductionAutism spectrum disorder (ASD) is characterised by difficulty with social communication and restricted, repetitive patterns of behaviour. This study aimed to improve understanding of the ASD patient experience with the treatment (bumetanide ...
Natalia Hawken, Bruno Falissard, Carl Choquet, Clement Francois, Jean Tardu, Ramona Schmid   +5 more
doaj   +1 more source

Concurrent absorption and secretion of airway surface liquids and bicarbonate secretion in human bronchioles. [PDF]

, 2019
Although small airways account for the largest fraction of the total conducting airway surfaces, the epithelial fluid and electrolyte transport in small, native airway epithelia has not been well characterized. Investigations have been limited, no doubt,
Quinton, Paul M, Shamsuddin, AKM
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Role of EEG background activity, seizure burden and MRI in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischaemic encephalopathy in the era of therapeutic hypothermia [PDF]

, 2016
OBJECTIVE: To investigate the role of EEG background activity, electrographic seizure burden, and MRI in predicting neurodevelopmental outcome in infants with hypoxic-ischaemic encephalopathy (HIE) in the era of therapeutic hypothermia.
Blennow, M, Boylan, GB, de Vries, LS, Groenendaal, F, Hallberg, B, NEonatal seizure treatment with Medication Off-patent (NEMO), ., Pressler, RM, Toet, MC, Weeke, LC   +8 more
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Safety, Tolerability, and EEG-Based Target Engagement of STP1 (PDE3,4 Inhibitor and NKCC1 Antagonist) in a Randomized Clinical Trial in a Subgroup of Patients with ASD

Biomedicines
This study aimed to evaluate the safety and tolerability of STP1, a combination of ibudilast and bumetanide, tailored for the treatment of a clinically and biologically defined subgroup of patients with Autism Spectrum Disorder (ASD), namely ASD ...
Craig A. Erickson, Laura Perez-Cano, Ernest V. Pedapati, Eric Painbeni, Gregory Bonfils, Lauren M. Schmitt, Hannah Sachs, Meredith Nelson, Lisa De Stefano, Grace Westerkamp, Adriano L. S. de Souza, Oliver Pohl, Offir Laufer, Gil Issachar, Thomas Blaettler, Jean-Marc Hyvelin, Lynn A. Durham   +16 more
doaj   +1 more source

Effects of antihypertensive agents on Alzheimer’s disease biomarkers in hypertensive rats with experimentally induced Alzheimer’s

Zanco Journal of Medical Sciences
Background and objective: The most common cause of dementia in the elderly is Alzheimer's disease (AD). Numerous research studies have demonstrated a connection between hypertension (HTN) and the risk of developing AD.
Marwan Qasim Nadir, Rojgar Hamed Ali
doaj   +1 more source

Feline vestibular disorders. Part II: diagnostic approach and differential diagnosis. [PDF]

, 1999
Results of a neurological examination usually permit localisation of a vestibular disorder to either the central or peripheral parts of the vestibular system. Many different disorders located in the same part of the vestibular system will produce similar
LeCouteur, RA, Vernau, KM
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