Results 81 to 90 of about 8,274 (202)
Bumetanide-Enhanced Phenobarbetal in Neonatal Seizure Model
Pediatric Neurology Briefs, 2008 Anticonvulsant efficacy of phenobarbital, bumetanide, and a combination of these drugs was studied in an in vitro hippocampal rat pup (4-7 days) preparation, with recurrent seizures induced by exposure to low-Mg solution, at the Department of Neurology ...
J Gordon Millichap
doaj +1 more source
Neonatal Seizure Models to Study Epileptogenesis
Frontiers in Pharmacology, 2018 Current therapeutic strategies for epilepsy include anti-epileptic drugs and surgical treatments that are mainly focused on the suppression of existing seizures rather than the occurrence of the first spontaneous seizure.
Yuka Kasahara +2 more
doaj +1 more source
Interaction of bumetanide derivatives with hepatocellular bile acid uptake
, 1993 The loop diuretic bumetanide is an organic monocarboxylic organic anion assumed to be transported into hepatocytes by a transport system for bile acids.
E. Petzinger +6 more
core +1 more source
Bumetanide in congestive heart failure
, 1976 Bumetanide, a new diuretic exerting its major effect on the ascending limb of the loop of Henle, was evaluated in 20 patients with congestive heart failure. Dosage ranged from 1 mg to 3 mg daily depending on the patient's condition.
Christensen, O. +2 more
core +1 more source
Selective effects of bumetanide on chloride transport in bullfrog cornea
, 1978 Frog corneas were mounted in a modified Ussing chamber and short-circuit current (SCC) and unidirectional Cl fluxes were measured. Bumetanide, a loop diuretic, at concentrations as low as 10(-7) M, reduced the SCC 29%.
H. F. Schoen, O. A. Candia
core +1 more source
, 2016 The Na(+)-K(+)-Cl(-) cotransporter NKCC1 plays a major role in the regulation of intraneuronal Cl(-) concentration. Abnormal functionality of NKCC1 has been implicated in several brain disorders, including epilepsy.
Feit, Peter W +5 more
core +1 more source
Binding of bumetanide to microsomes from optic ganglia of the squid, Loligo pealei
, 1990 Saturable high-affinity binding of [3H] bumetanide [dissociation constant (KD) = 80 nM] was measured in microsomal membranes prepared from squid optic ganglia.
J. M. Russell +2 more
core +1 more source
FORMULATION AND DEVELOPMENT OF ORAL DISSOLVING FILMS OF BUMETANIDE
, 2016 Objective: Formulation and Development of oral dissolving Films of Bumetanide. Materials and methods: BUMETANIDE, HPMC E-50, HPMC E-5, HPMC E-3, PE, 4000 (Flakes) and Aspartame. Citric Acid could be formulated with low viscosity film formers viz.
Dr.A.Yasodha
core +1 more source
Uptake of bumetanide into isolated rat hepatocytes and primary liver cell cultures
, 1989 Uptake of bumetanide into rat liver cells was investigated using isolated hepatocytes and primary cell cultures. The kinetics of [3H]-bumetanide uptake revealed two saturable components in addition to an unsaturable component.
E. Petzinger +4 more
core +1 more source
Systemic administration of bumetanide blocked inhibitory avoidance learning.
, 2016 (A) Rats were administered vehicle and bumetanide intravenously 1 hr prior to training session. The test was carried out 24 hrs later. Result showed that retention latency of the bumetanide-treated group was decreased significantly compared with vehicle ...
Tamara G. Amstislavskaya (598275) +5 more
core +1 more source