Results 81 to 90 of about 10,959 (212)
Acta Physiologica, Volume 242, Issue 2, February 2026.ABSTRACT Background and Aims Colonic bicarbonate secretion is mediated by the chloride/bicarbonate exchanger SLC26A3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Dysfunction of either causes luminal acidosis, altered mucus properties, and inflammation.
Mahdi Amiri, Azam Salari, Ursula Seidler
wiley +1 more source
The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR [PDF]
, 2016 Optimal fetal lung growth requires anion-driven fluid secretion into the lumen of the developing organ. The fetus is hypercalcemic compared to the mother and here we show that in the developing human lung this hypercalcaemia acts on the extracellular ...
Brennan, Sarah C. +10 more
core +2 more sources
Frontiers in Molecular Neuroscience, 2017 Fragile X syndrome (FXS) is the most common monogenetic cause of intellectual disability and autism. The disorder is characterized by altered synaptic plasticity in the brain.
Shimriet Zeidler +3 more
doaj +1 more source
Single-case experimental designs for bumetanide across neurodevelopmental disorders: BUDDI protocol
BMC Psychiatry, 2022 Background Bumetanide is a selective NKCC1 chloride importer antagonist which is being repurposed as a mechanism-based treatment for neurodevelopmental disorders (NDDs).
Lisa Geertjens +6 more
doaj +1 more source
Predictors of a Gabapentinoid–Loop‐Diuretic Prescribing Cascade in U.S. Nursing Home Residents
Journal of the American Geriatrics Society, Volume 74, Issue 2, Page 336-344, February 2026.Among 23,544 older adult long‐stay nursing home residents who initiated a gabapentinoid in the nursing home (2016–2022), 4.2% experienced a loop diuretic prescribing cascade within 90 days. Predictors of the prescribing cascade included older age, higher medication burden (≥ 15 medications), current receipt of non‐loop diuretics, and titration of ...
Kaleen N. Hayes +7 more
wiley +1 more source
Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium. [PDF]
, 2015 The endolymphatic sac (ES) is a cystic organ that is a part of the inner ear and is connected to the cochlea and vestibule. The ES is thought to be involved in inner ear ion homeostasis and fluid volume regulation for the maintenance of hearing and ...
Choi, Jae Young +8 more
core +2 more sources
British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 220-229, January 2026.Aims This study investigated factors associated with and outcomes of combined loop diuretics with hydrochlorothiazide (HCTZ) for acute decompensated heart failure (ADHF). Methods In this retrospective study, adults hospitalized for ADHF and who received intravenous loop diuretics between January 2016 and March 2023 were enrolled.
Chia‐Chen Hsu +6 more
wiley +1 more source
Euglycemic Ketoacidosis Induced by Dapagliflozin in a Non‐Diabetic Patient With Cardiac Amyloidosis
Clinical Case Reports, Volume 14, Issue 1, January 2026.ABSTRACT Dapagliflozin, though beneficial in heart failure, can rarely cause euglycemic ketoacidosis even in non‐diabetic patients. Clinicians should maintain a high index of suspicion for metabolic acidosis in patients on SGLT2 inhibitors presenting with unexplained illness, regardless of blood glucose level.
Salhamoud Abdelfatah Saleh Hamoud +1 more
wiley +1 more source
Hypoxia/Reoxygenation Effects on Ion Transport across Rat Colonic Epithelium [PDF]
, 2016 Ischemia causes severe damage in the gastrointestinal tract. Therefore, it is interesting to study how the barrier and transport functions of intestinal epithelium change under hypoxia and subsequent reoxygenation.
Ervice Pouokam +2 more
core +1 more source
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.Abstract INTRODUCTION It remains unclear whether specific blood pressure components—systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), or mean arterial pressure (MAP)—are similarly associated with white matter hyperintensity (WMH) burden across sexes within racial and ethnic groups.
Cellas A. Hayes +3 more
wiley +1 more source