Results 121 to 130 of about 5,998 (173)
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Clinical Pharmacology and Therapeutics, 1983
We assessed the response to and handling of furosemide and bumetanide in 30 experiments with the former and 46 with the latter in normal subjects. Oral doses of furosemide (20, 40, and 80 mg) were used, and subjects received oral doses of 0.5, 1, and 2 mg bumetanide and intravenous doses of 0.5 and 1 mg bumetanide.
D C, Brater +4 more
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We assessed the response to and handling of furosemide and bumetanide in 30 experiments with the former and 46 with the latter in normal subjects. Oral doses of furosemide (20, 40, and 80 mg) were used, and subjects received oral doses of 0.5, 1, and 2 mg bumetanide and intravenous doses of 0.5 and 1 mg bumetanide.
D C, Brater +4 more
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In vitro Metabolism of Bumetanide
Pharmaceutical Research, 1984A new metabolite of the diuretic drug bumetanide, the 4-[(4'-hydroxy)-phenoxy] analog (7), was identified in incubation mixtures of rat liver microsomes. Phenobarbital and clofibrate pretreatment to induce microsomal enzymes changed the relative amounts of the six metabolites formed.
GROSA, Giorgio +3 more
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The Journal of Clinical Pharmacology, 1981
Abstract:The diuretic action of bumetanide was compared with that of furosemide following oral and intravenous administration of equipotent doses in the rat, mouse, cat, rabbit, and dog. The onset of the bumetanide‐induced diuresis was rapid and lasted 4 to 6 hours.
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Abstract:The diuretic action of bumetanide was compared with that of furosemide following oral and intravenous administration of equipotent doses in the rat, mouse, cat, rabbit, and dog. The onset of the bumetanide‐induced diuresis was rapid and lasted 4 to 6 hours.
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The Journal of Clinical Pharmacology, 1981
Abstract: The metabolism of bumetanide is reviewed, with emphasis on the relationship between metabolism and diuretic activity. Substantial evidence has been obtained for the thesis that diuretic activity is dependent on the amount of bumetanide which reaches the renal tubule.
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Abstract: The metabolism of bumetanide is reviewed, with emphasis on the relationship between metabolism and diuretic activity. Substantial evidence has been obtained for the thesis that diuretic activity is dependent on the amount of bumetanide which reaches the renal tubule.
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Acta Crystallographica Section C Crystal Structure Communications, 1995
The structure of sodium 3-(aminosulfonyl)-5-(butylamino)-4-phenoxybenzoate trihydrate (sodium bumetanide trihydrate), Na + .C 17 H 19 N 2 O 5 S - .3H 2 O, consists of a layer of sodium ions and water molecules between two layers of bumetanide molecules.
SAVIANO M +4 more
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The structure of sodium 3-(aminosulfonyl)-5-(butylamino)-4-phenoxybenzoate trihydrate (sodium bumetanide trihydrate), Na + .C 17 H 19 N 2 O 5 S - .3H 2 O, consists of a layer of sodium ions and water molecules between two layers of bumetanide molecules.
SAVIANO M +4 more
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Indomethacin and the response to bumetanide
Clinical Pharmacology and Therapeutics, 1980Pretreatment of 8 normal subjects with 100 mg indomethacin decreased the response to bumetanide; cumulative 4-hr excretion of sodium due to 1.0 mg of bumetanide was reduced from 276 +/- 22.9 to 202 +/- 20.9 mEq (p less than 0.003). Effects on volume and Cl paralleled those on Na while K excretion was not affected.
Craig Brater +3 more
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Developmental Pharmacology and Therapeutics, 2017
Bumetanide binding to human serum albumin was studied using ultrafiltration. The first stoichiometric binding constant for bumetanide is 6.4 × 10^4 M^-1. Bumetanide competes with bilirubin for human serum albumin binding, having a K(Displ) (displacement constant) of 6.2 × 10^3 M^-1 measured by the peroxidase method.
A, Robertson, W, Karp
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Bumetanide binding to human serum albumin was studied using ultrafiltration. The first stoichiometric binding constant for bumetanide is 6.4 × 10^4 M^-1. Bumetanide competes with bilirubin for human serum albumin binding, having a K(Displ) (displacement constant) of 6.2 × 10^3 M^-1 measured by the peroxidase method.
A, Robertson, W, Karp
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The Journal of Clinical Pharmacology, 1981
Abstract: Upon administration of bumetanide in normal human subjects, both glomerular filtration rate and effective renal plasma flow were increased, in approximately proportional amounts. Sodium excretion rose to 16 per cent of filtered load, whereas there was a chloriuresis of 23 per cent.
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Abstract: Upon administration of bumetanide in normal human subjects, both glomerular filtration rate and effective renal plasma flow were increased, in approximately proportional amounts. Sodium excretion rose to 16 per cent of filtered load, whereas there was a chloriuresis of 23 per cent.
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