Results 51 to 60 of about 1,302,629 (287)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Eksplorasi berpikir kreatif melalui discovery learning Bruner

Humanika: Kajian Ilmiah Mata Kuliah Umum, 2020
Creative thinking is an essential component of advanced mathematical thinking. The components of creative thinking are lateral thinking (creating one’s own and non-routine ways), divergent thinking (using a variety of ways), and convergent-integrative ...
Mulin Nu'man
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

DEVELOPMENT OF DIVERGENT THINKING IN PRIMARY SCHOOL MOTHER TONGUE LESSONS

, 2022
Annotation: This article discusses the methods and technologies for the formation of students' thinking in primary school native language classes, including the development of divergent thinking, the achievement of intellectual ...
Umarkulova Muhayyo Azamjon qizi
core   +1 more source

Development of divergent thinking in children aged 5–6 years through klecksographyDevelopment of divergent thinking in children aged 5–6 years through klecksography

Современное дошкольное образование
Background. Divergent thinking is the ability to generate many different original ideas, is an important component of human creative potential. Preschool age is a sensitive period for the development of divergent thinking in children.
Tatiana E. Chernokova
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Divergent thinking of the mentally retarded [PDF]

, 1974
There is a need for divergent thinking among educable mentally retarded in our society. rigid, structured thinking is being broadened to include and encourage divergent thinking.
Ortego, Mary Alice
core  

Mind Mapping Training’s Effects on Divergent Thinking Skills: Detection Based on EEG Data

Applied Sciences
As a translation strategy, mind mapping has a positive influence on the development of students’ divergent thinking skills. However, research on how mind mapping affects divergent thinking has primarily relied on traditional testing methods, which mainly
Ting Liu, Zhisheng Wang, Hao Yu
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source