Diversity-Oriented Synthesis: Amino Acetophenones as Building Blocks for the Synthesis of Natural Product Analogs [PDF]
Pharmaceuticals, 2021 Diversity-Oriented Synthesis (DOS) represents a strategy to obtain molecule libraries with diverse structural features starting from one common compound in limited steps of synthesis.
Mathias Eymery +2 more
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Beilstein Journal of Organic Chemistry, 2012 Two-directional synthesis represents an ideal strategy for the rapid elaboration of simple starting materials and their subsequent transformation into complex molecular architectures.
Kieron M. G. O’Connell +3 more
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Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides [PDF]
Nature Communications, 2023 Liam Hudson +33 more
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Mask and Release Strategy‐Enabled Diversity‐Oriented Synthesis for DNA‐Encoded Library [PDF]
Advanced ScienceAn ideal DNA‐encoded library (DEL) selection requires the library to consist of diverse core skeletons and cover chemical space as much as possible. However, the lack of efficient on‐DNA synthetic approaches toward core skeletons has greatly restricted ...
Silin Zhang +9 more
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Diversity-Oriented Synthesis and Optical Properties of Bichromophoric Pyrrole-Fluorophore Conjugates [PDF]
Frontiers in Chemistry, 2018 The mild reaction conditions of the palladium-copper coupling-isomerization reaction open a highly convergent, chromogenic route to blue emissive pyrroles in the sense of a consecutive four-component reaction.
Oliver Grotkopp +2 more
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Diversity oriented synthesis for novel anti-malarials. [PDF]
Syst Synth Biol, 2015 Malaria a global pandemic has engulfed nearly 0.63 million people globally. It is high time that a cure for malaria is required to stop its ever increasing menace. Our commentary discusses the advent and contribution of diversity oriented synthesis (DOS) in the drug discovery efforts towards developing cure for malaria.
Bathula C, Singh S, Sen S.
europepmc +4 more sources
Diversity-Oriented Approaches toward the Synthesis of Cyclophanes
ACS OmegaHere, we describe synthetic approaches to a variety of cyclophanes involving transition-metal-catalyzed reactions such as the Suzuki-Miyaura cross-coupling, olefin metathesis, enyne metathesis, Glaser-Eglinton coupling, Yamamoto coupling, etc. On several occasions, alkylation, benzylation, Grignard reagents, and potassium thioacetate have been used for
Sambasivarao Kotha, Milind Meshram
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Synthesis of (−)-julocrotine and a diversity oriented Ugi-approach to analogues and probes
Beilstein Journal of Organic Chemistry, 2011 An improved total synthesis of (−)-julocrotine in three steps from Cbz-glutamine, in 51% overall yield, is presented. To demonstrate the potential of the heterocyclic moiety for diversity oriented synthesis, a series of (−)-julocrotine analogues was ...
Ricardo A. W. Neves Filho +2 more
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A Brief Overview of Two Major Strategies in Diversity-Oriented Synthesis: Build/Couple/Pair and Ring-Distortion [PDF]
Frontiers in Chemistry, 2018 In the interdisciplinary research field of chemical biology and drug discovery, diversity-oriented synthesis (DOS) has become indispensable in the construction of novel small-molecule libraries rich in skeletal and stereochemical diversity.
Sihyeong Yi +3 more
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Diversity-oriented synthesis of analogues of the novel macrocyclic peptide FR-225497 through late stage functionalization [PDF]
Beilstein Journal of Organic Chemistry, 2015 A concise synthetic approach to a class of biologically interesting cyclic tetrapeptides is reported which involves a late-stage functionalization of a macrocyclic scaffold through cross metathesis in an attempt to create diversity.
Jyotiprasad Mukherjee +2 more
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