Aminoazole-Based Diversity-Oriented Synthesis of Heterocycles [PDF]
Frontiers in Chemistry, 2018 The comprehensive review contains the analysis of literature data concerning reactions of heterocyclization of aminoazoles and demonstrates the application of these types of transformations in diversity-oriented synthesis.
Maryna V. Murlykina +7 more
doaj +7 more sources
Diversity-Oriented Synthesis as a Tool for Chemical Genetics [PDF]
Molecules, 2014 Chemical genetics is an approach for identifying small molecules with the ability to induce a biological phenotype or to interact with a particular gene product, and it is an emerging tool for lead generation in drug discovery.
Elena Lenci +2 more
doaj +8 more sources
Diversity-oriented synthesis of glycomimetics [PDF]
Communications Chemistry, 2021 Glycomimetics are structural mimics of carbohydrates that can replicate their biological activity but have improved drug-like properties. Here, using proline-catalysed α-halogenation/aldol cascades, carbohydrate building blocks are readily assembled and ...
Michael Meanwell +14 more
doaj +5 more sources
Diversity-oriented synthesis encoded by deoxyoligonucleotides [PDF]
Nature Communications, 2023 Diversity-oriented synthesis (DOS) is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in the elucidation of novel biological mechanisms.
Liam Hudson +33 more
doaj +6 more sources
Diversity-oriented synthesis of 17-spirosteroids [PDF]
Beilstein Journal of Organic Chemistry, 2020 A diversity-oriented synthesis (DOS) approach has been used to functionalize 17-ethynyl-17-hydroxysteroids through a one-pot procedure involving a ring-closing enyne metathesis (RCEYM) and a Diels–Alder reaction on the resulting diene, under microwave ...
Benjamin Laroche +3 more
doaj +6 more sources
Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation [PDF]
Beilstein Journal of Organic Chemistry, 2019 We report a new synthetic approach to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chemistry and click reaction. Using flow cytometry, it was shown for the first
Sambasivarao Kotha +5 more
doaj +5 more sources
Editorial: Diversity Oriented Synthesis [PDF]
Frontiers in Chemistry, 2019 Andrea Basso, Seung Bum Park, Lisa Moni
doaj +6 more sources
A Multidimensional Diversity‐Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles [PDF]
Angewandte Chemie - International Edition, 2016 AbstractSynthetic macrocycles are an attractive area in drug discovery. However, their use has been hindered by a lack of versatile platforms for the generation of structurally (and thus shape) diverse macrocycle libraries. Herein, we describe a new concept in library synthesis, termed multidimensional diversity‐oriented synthesis, and its application ...
David R Spring +2 more
exaly +6 more sources
Diversity-oriented synthesis of nanographenes enabled by dearomative annulative π-extension [PDF]
Nature Communications, 2021 Nanographenes and polycyclic aromatic hydrocarbons (PAHs) are important classes of compounds with numerous applications, but challenging to access due to a lack of programmable and diversity-oriented methods. Here, the authors report a diversity-oriented,
Wataru Matsuoka +3 more
doaj +2 more sources
Substrate-Controlled Diversity-Oriented Synthesis of Novel Polycyclic Frameworks via [4 + 2] and [3 + 2] Annulations of Ninhydrin-Derived MBH Adducts with 3,4-Dihydroisoquinolines [PDF]
Molecules, 2023 Substrate-controlled diversity-oriented synthesis of polycyclic frameworks via [4 + 2] and [3 + 2] annulations between ninhydrin-derived Morita–Baylis–Hillman (MBH) adducts and 3,4-dihydroisoquinolines under similar reaction conditions have been ...
Kaikai Wang +7 more
doaj +2 more sources