Results 41 to 50 of about 33,968 (135)

Stereodivergent Diversity Oriented Synthesis of Piperidine Alkaloids

European Journal of Organic Chemistry, 2006
AbstractAlkylidenetitanium reagents enable the reagent‐controlled high throughput asymmetric synthesis of 2‐substituted piperidines and rapid access to multiple cyclic imines using solid phase synthesis (SPS). The Schrock carbenes, generated by reduction of thioacetals, convert resin‐bound esters into enol ethers.
Louis Adriaenssens, Carolyn A. Austin, Mairi Gibson, David Smith, Richard C. Hartley   +4 more
openaire   +3 more sources

One-pot syntheses of blue-luminescent 4-aryl-1H-benzo[f]isoindole-1,3(2H)-diones by T3P® activation of 3-arylpropiolic acids

Beilstein Journal of Organic Chemistry, 2017
In situ activation of 3-arylpropiolic acids with T3P® (n-propylphosphonic acid anhydride) initiates a domino reaction furnishing 4-arylnaphtho[2,3-c]furan-1,3-diones in excellent yields.
Melanie Denißen, Alexander Kraus, Guido J. Reiss, Thomas J. J. Müller   +3 more
doaj   +1 more source

Targeting Oncogenic Protein-Protein Interactions by Diversity Oriented Synthesis and Combinatorial Chemistry Approaches

Molecules, 2011
We are currently witnessing a decline in the development of efficient new anticancer drugs, despite the salient efforts made on all fronts of cancer drug discovery.
Andreas G. Tzakos, Demosthenes Fokas, Charlie Johannes, Vassilios Moussis, Eleftheria Hatzimichael, Evangelos Briasoulis   +5 more
doaj   +1 more source

Contemporary Applications of Chemical Libraries for Drug Discovery and Methods for Their Synthesis

ChemistryEurope
Chemical libraries underpin contemporary drug discovery by enabling systematic exploration of chemical space for ligands. This review summarizes practical principles for designing, comparing, and selecting libraries, emphasizing how “diversity” can be ...
Tobias N. Hansen, Nils J. V. Hansen
doaj   +1 more source

Diversity oriented total synthesis (DOTS) of pyridoquinazolinone alkaloids and their analogues

Tetrahedron Chem
A short diversity oriented total synthesis (DOTS) of substituted rutaecarpines, homo-luotonins, homo-vasicinone, homo-isaindigotones and homo-vasnetine has been achieved from the key tricyclic intermediate.
Sivappa Rasapalli, Yanchang Huang, Vamshikrishna Reddy Sammeta, Reem Alshehry, Fazmina Anver, James A. Golen, Shivasankar Krishnamoorthy, Subhash P. Chavan   +7 more
doaj   +1 more source

Diversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction

Nature Communications, 2016
Diversity-oriented synthesis is useful for generating complex molecular structures occupying diverse molecular space. Here the authors report a strategy to access libraries of privileged heterocyclic structures, and furthermore identify an inhibitor of ...
Jonghoon Kim, Jinjoo Jung, Jaeyoung Koo, Wansang Cho, Won Seok Lee, Chanwoo Kim, Wonwoo Park, Seung Bum Park   +7 more
doaj   +1 more source

A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens

Nature Communications, 2019
Preparation of xanthene-containing compounds has been limited due to structural bias existing methods pose. Here, the authors developed a mild, diversity-oriented method for rhodamines synthesis, leading to the finding of compounds with antibacterial ...
Xiao Luo, Liujia Qian, Yansheng Xiao, Yao Tang, Yang Zhao, Xia Wang, Luyan Gu, Zuhai Lei, Jianming Bao, Jiahui Wu, Tingting He, Fupin Hu, Jing Zheng, Honglin Li, Weiping Zhu, Lei Shao, Xiaojing Dong, Daijie Chen, Xuhong Qian, Youjun Yang   +19 more
doaj   +1 more source

Diversity-Oriented Synthesis of a Library of Substituted Tetrahydropyrones Using Oxidative Carbon-Hydrogen Bond Activation and Click Chemistry

Molecules, 2011
Eighteen (2RS,6RS)-2-(4-methoxyphenyl)-6-(substituted ethyl)dihydro-2H-pyran-4(3H)ones were synthesized via a DDQ-mediated oxidative carbon-hydrogen bond activation reaction.
Paul E. Floreancig, Lei Liu, Peter Wipf, Matthew G. LaPorte, Ramy Farid, Nilesh Zaware   +5 more
doaj   +1 more source

Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives

Molecules, 2018
The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described.
Luciana Méndez, Andrés A. Poeylaut-Palena, Ernesto G. Mata   +2 more
doaj   +1 more source

Samarium(II) folding cascades involving hydrogen atom transfer for the synthesis of complex polycycles

Nature Communications, 2018
Diversity-oriented synthesis is a valuable strategy to construct complex molecules of medicinal interest. Here, the authors show a folding cascade strategy to convert linear substrates into polycyclic compounds with multiple stereocentres by combining ...
Mateusz P. Plesniak, Monserrat H. Garduño-Castro, Philipp Lenz, Xavier Just-Baringo, David J. Procter   +4 more
doaj   +1 more source