Results 21 to 30 of about 5,221,708 (261)

Diversity-Oriented Synthesis of Functional Polymers with Multisubstituted Small Heterocycles by Facile Stereoselective Multicomponent Polymerizations [PDF]

, 2022
Multicomponent polymerization (MCP) has received world-wide attention as a powerful synthetic strategy toward various polymers with complex structures. However, few studies have been reported to fully utilize the monomer combination diversity of MCPs to ...
Xinnan, Wang, Ben Zhong, Tang, Haoke, Zhang, Junyi, Gong, Jacky W. Y., Lam, Parvej, Alam, Ting, Han   +6 more
core   +2 more sources

Diversity Oriented Clicking: Synthesis of beta-Substituted Alkenyl Sulfonyl Fluorides as Covalent Human Neutrophil Elastase Inhibitors [PDF]

, 2022
Diversity Oriented Clicking (DOC) is a discovery method geared towards the rapid synthesis of functional libraries. It combines the best attributes of both classical and modern click chemistries. DOC strategies center upon the chemical diversification of
Yunfei, Cheng, John R. , Cappiello, Stefano, Forli, Seiya, Kitamura, Joshua A., Homer, K. Barry, Sharpless, Jordan L., Woehl, Gencheng , Li, Giulia, Bianco, Dennis W., Wolan, Christopher J. , Smedley, Marie-Claire, Giel, John E., Moses   +12 more
core   +2 more sources

Diversity-Oriented Synthesis of Azaspirocycles [PDF]

Organic Letters, 2004
Multicomponent condensation of N-diphenylphosphinoylimines, alkynes, zirconocene hydrochloride, and diiodomethane provides a rapid access to omega-unsaturated dicyclopropylmethylamines. These novel building blocks are converted into heterocyclic 5-azaspiro[2.4]heptanes, 5-azaspiro-[2.5]octanes, and 5-azaspiro[2.6]nonanes by means of selective ring ...
Peter, Wipf, Corey R J, Stephenson, Maciej A A, Walczak   +2 more
openaire   +3 more sources

Diversity-Oriented Synthesis of Highly Fluorescent Fused Isoquinolines for Specific Subcellular Localization

, 2019
A multicomponent diversity-oriented synthesis of new highly emissive tetracyclic isoquinolines that target specific organelles is described. The title compounds were prepared via a three-step protocol starting with an Ugi four-component reaction ...
Davir González-Calderón (8181624), Yoarhy A. Amador-Sánchez (8181618), Arturo Jiménez-Sánchez (1582204), Ricardo Flores-Cruz (8181621), Luis D. Miranda (1489969), Andrés Aguilar-Granda (1432672), Braulio Rodríguez-Molina (1432660), Cynthia Orta (8181627)   +7 more
core   +7 more sources

Diversity-oriented synthesis of macrocyclic peptidomimetics [PDF]

Proceedings of the National Academy of Sciences, 2011
Structurally diverse libraries of novel small molecules represent important sources of biologically active agents. In this paper we report the development of a diversity-oriented synthesis strategy for the generation of diverse small molecules based around a common macrocyclic peptidomimetic framework, containing structural motifs ...
Albert, Isidro-Llobet, Tiffanie, Murillo, Paula, Bello, Agostino, Cilibrizzi, James T, Hodgkinson, Warren R J D, Galloway, Andreas, Bender, Martin, Welch, David R, Spring   +8 more
openaire   +2 more sources

Strategies for the Diversity-Oriented Synthesis of Macrocycles [PDF]

Chemical Reviews, 2019
Macrocycles have long been recognized as useful chemical entities for medicine, with naturally occurring and synthetic macrocycles clinically approved for use as prescription drugs. Despite this promise, the synthesis of collections of macrocycles has been historically challenging due to difficulties in the formation of large rings.
Mortensen, Kim T, Osberger, Thomas J, King, Thomas A, Sore, Hannah F, Spring, David R   +4 more
openaire   +3 more sources

Multicomponent Reactions for the Synthesis of Active Pharmaceutical Ingredients

Pharmaceuticals, 2022
Multicomponent reactions 9i.e., those that engage three or more starting materials to form a product that contains significant fragments of all of them), have been widely employed in the construction of compound libraries, especially in the context of ...
Ángel Cores, José Clerigué, Emmanuel Orocio-Rodríguez, J. Carlos Menéndez   +3 more
doaj   +1 more source

Diversity-Oriented Synthesis of ERα Modulators via Mitsunobu Macrocyclization

, 2022
The diversity of cyclic peptides was expanded by elaborating Mitsunobu macrocyclization, tethering various hydroxy acid building blocks with different Nε-amine substituents.
Lizhi Zhu (1608625), Qinhong Luo (12535428), Jinqiang Zhang (709289), Min Yang (146229), Junrong Huang (1608622), Zigang Li (606370), Chuan Dai (2087050), Huilong Fang (4512496), Heng Yang (590400), Chenshan Lian (8281266), Feng Yin (681489)   +10 more
core   +1 more source

Diversity-Oriented Synthesis of Fluoromethylated Arenes via Palladium-Catalyzed CH Fluoromethylation of Aryl Iodides

, 2022
Herein we report the first versatile and expeditious method for the site-selective C–H fluoromethylation of aryl iodides via Pd/norbornene cooperative catalysis, which could work as a robust toolbox for the diversity-oriented synthesis (DOS) of ...
Gaopeng Song (2332066), Yihan Chen, Shuxin Chen, Ri-Yuan Tang (546362), Yiming Du (9075528), Ri-Yuan Tang, Hanhong Xu (146703), Guangkai Yao (12054664), Zhaodong Li (1364562), Hanhong Xu, Ao Huang, Gaopeng Song, Yun-Lin Liu (2178446), Guangkai Yao, Yiming Du, Yun-Lin Liu, Zhaodong Li, Ao Huang (508797), Yihan Chen (517320), Shuxin Chen (6898883)   +19 more
core   +1 more source

Synthesis of skeletally diverse alkaloid-like molecules: exploitation of metathesis substrates assembled from triplets of building blocks

Beilstein Journal of Organic Chemistry, 2013
A range of metathesis substrates was assembled from triplets of unsaturated building blocks. The approach involved the iterative attachment of a propagating and a terminating building block to a fluorous-tagged initiating building block.
Sushil K. Maurya, Mark Dow, Stuart Warriner, Adam Nelson   +3 more
doaj   +1 more source