Results 21 to 30 of about 33,968 (135)
Diversity-Oriented Synthesis of Azaspirocycles [PDF]
Organic Letters, 2004 Multicomponent condensation of N-diphenylphosphinoylimines, alkynes, zirconocene hydrochloride, and diiodomethane provides a rapid access to omega-unsaturated dicyclopropylmethylamines. These novel building blocks are converted into heterocyclic 5-azaspiro[2.4]heptanes, 5-azaspiro-[2.5]octanes, and 5-azaspiro[2.6]nonanes by means of selective ring ...
Peter, Wipf +2 more
openaire +3 more sources
Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β [PDF]
ACS Medicinal Chemistry Letters, 2016 Angela Koehler +2 more
exaly +2 more sources
Multicomponent Reactions for the Synthesis of Active Pharmaceutical Ingredients
Pharmaceuticals, 2022 Multicomponent reactions 9i.e., those that engage three or more starting materials to form a product that contains significant fragments of all of them), have been widely employed in the construction of compound libraries, especially in the context of ...
Ángel Cores +3 more
doaj +1 more source
Strategies for the Diversity-Oriented Synthesis of Macrocycles [PDF]
Chemical Reviews, 2019 Macrocycles have long been recognized as useful chemical entities for medicine, with naturally occurring and synthetic macrocycles clinically approved for use as prescription drugs. Despite this promise, the synthesis of collections of macrocycles has been historically challenging due to difficulties in the formation of large rings.
Mortensen, Kim T +4 more
openaire +3 more sources
Diversity-oriented synthesis of macrocyclic peptidomimetics [PDF]
Proceedings of the National Academy of Sciences, 2011 Structurally diverse libraries of novel small molecules represent important sources of biologically active agents. In this paper we report the development of a diversity-oriented synthesis strategy for the generation of diverse small molecules based around a common macrocyclic peptidomimetic framework, containing structural motifs ...
Albert, Isidro-Llobet +8 more
openaire +2 more sources
Diversity-Oriented Synthetic Strategies Applied to Cancer Chemical Biology and Drug Discovery
Molecules, 2014 How can diversity-oriented strategies for chemical synthesis provide chemical tools to help shape our understanding of complex cancer pathways and progress anti-cancer drug discovery efforts?
Ian Collins, Alan M. Jones
doaj +1 more source
Diversity‐Oriented Catalytic Asymmetric Dearomatization of Indoles with o‐Quinone Diimides
Advanced Science, 2023 Herein, the first diversity‐oriented catalytic asymmetric dearomatization of indoles with o‐quinone diimides (o‐QDIs) is reported. The catalytic asymmetric dearomatization (CADA) of indoles is one of the research focuses in terms of the structural and ...
Hao‐Jie Gao +8 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2013 A range of metathesis substrates was assembled from triplets of unsaturated building blocks. The approach involved the iterative attachment of a propagating and a terminating building block to a fluorous-tagged initiating building block.
Sushil K. Maurya +3 more
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Química NovaDrug discovery often involves screening synthetic small molecules for their ability to bind to a macromolecular target. Target-Oriented Synthesis of a specific compound or a focused library can be planned combining retrosynthetic analysis and rational ...
Diego Pereira Sangi
doaj +1 more source
Molecules, 2020 This review focuses upon the use of nitroso Diels−Alder reactions as a structural complexity generating reaction that has been so far a quite scarcely treated topic, despite its potential.
Andrea Menichetti +2 more
doaj +1 more source