Results 31 to 40 of about 5,221,708 (261)
Diversity-Oriented Library Synthesis from Steviol and Isosteviol-Derived Scaffolds
, 2020 The readily available natural product stevioside provides a unique diterpene core structure that can be explored for small molecule library development by diversity-oriented synthesis and functional group transformations.
Trinh A. D. Holth (8458386) +3 more
core +1 more source
Molecules, 2020 This review focuses upon the use of nitroso Diels−Alder reactions as a structural complexity generating reaction that has been so far a quite scarcely treated topic, despite its potential.
Andrea Menichetti +2 more
doaj +1 more source
Diversity‐Oriented Catalytic Asymmetric Dearomatization of Indoles with o‐Quinone Diimides
Advanced Science, 2023 Herein, the first diversity‐oriented catalytic asymmetric dearomatization of indoles with o‐quinone diimides (o‐QDIs) is reported. The catalytic asymmetric dearomatization (CADA) of indoles is one of the research focuses in terms of the structural and ...
Hao‐Jie Gao +8 more
doaj +1 more source
, 2016 Diversity-oriented synthesis of structurally complex and diverse small molecules can be used as the first step in a process to explore cellular and organismal pathways.
Helen E. Blackwell (1247094) +3 more
core +2 more sources
Química NovaDrug discovery often involves screening synthetic small molecules for their ability to bind to a macromolecular target. Target-Oriented Synthesis of a specific compound or a focused library can be planned combining retrosynthetic analysis and rational ...
Diego Pereira Sangi
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2015 A concise synthetic approach to a class of biologically interesting cyclic tetrapeptides is reported which involves a late-stage functionalization of a macrocyclic scaffold through cross metathesis in an attempt to create diversity.
Jyotiprasad Mukherjee +2 more
doaj +1 more source
Synthesis of (−)-julocrotine and a diversity oriented Ugi-approach to analogues and probes
Beilstein Journal of Organic Chemistry, 2011 An improved total synthesis of (−)-julocrotine in three steps from Cbz-glutamine, in 51% overall yield, is presented. To demonstrate the potential of the heterocyclic moiety for diversity oriented synthesis, a series of (−)-julocrotine analogues was ...
Ricardo A. W. Neves Filho +2 more
doaj +1 more source
Frontiers in Chemistry, 2018 An Ugi multicomponent reaction with chiral cyclic amino acids, benzyl isocyanide and cyclic ketones (or acetone) has been exploited as key step for the generation of peptidomimetics.
Lisa Moni +5 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Teaching Target-Oriented and Diversity-Oriented Organic Synthesis at Harvard University [PDF]
, 2002 Diversity-oriented synthesis presents many formidable challenges to the practitioners of synthetic organic chemistry. Those challenges include the effective teaching of this new and evolving discipline to ensure that students are well positioned to begin
Lalic, Gojko, Burke, Martin D
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