Results 31 to 40 of about 33,968 (135)

Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds

Frontiers in Chemistry, 2018
An Ugi multicomponent reaction with chiral cyclic amino acids, benzyl isocyanide and cyclic ketones (or acetone) has been exploited as key step for the generation of peptidomimetics.
Lisa Moni, Fabio De Moliner, Silvia Garbarino, Jörn Saupe, Christian Mang, Andrea Basso   +5 more
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Synthesis of a Small Library of Nature-Inspired Xanthones and Study of Their Antimicrobial Activity

Molecules, 2020
A series of thirteen xanthones 3–15 was prepared based on substitutional (appendage) diversity reactions. The series was structurally characterized based on their spectral data and HRMS, and the structures of xanthone derivatives 1, 7, and 8 were ...
Diana I. S. P. Resende, Patrícia Pereira-Terra, Joana Moreira, Joana Freitas-Silva, Agostinho Lemos, Luís Gales, Eugénia Pinto, Maria Emília de Sousa, Paulo Martins da Costa, Madalena M. M. Pinto   +9 more
doaj   +1 more source

Diversity-oriented functionalization of 2-pyridones and uracils

Nature Communications, 2021
Diversity-oriented synthesis of 2-pyridone and uracil derivatives is in urgent need in medicinal chemistry as they are useful pharmacophores. Here the authors show that palladium/norbornene cooperative catalysis enabled dual-functionalization of ...
Yong Shang, Chenggui Wu, Qianwen Gao, Chang Liu, Lisha Li, Xinping Zhang, Hong-Gang Cheng, Shanshan Liu, Qianghui Zhou   +8 more
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High-speed vibration-milling-promoted synthesis of symmetrical frameworks containing two or three pyrrole units

Beilstein Journal of Organic Chemistry, 2017
The pseudo-five-component reaction between β-dicarbonyl compounds (2 molecules), diamines and α-iodoketones (2 molecules), prepared in situ from aryl ketones, was performed efficiently under mechanochemical conditions involving high-speed vibration ...
Marco Leonardi, Mercedes Villacampa, J. Carlos Menéndez   +2 more
doaj   +1 more source

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

Beilstein Journal of Organic Chemistry, 2012
Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity ...
Chao Che, Song Li, Bo Yang, Shengchang Xin, Zhixiong Yu, Taofeng Shao, Chuanye Tao, Shuo Lin, Zhen Yang   +8 more
doaj   +1 more source

Divergent Synthesis of Novel Five-Membered Heterocyclic Compounds by Base-Mediated Rearrangement of Acrylamides Derived from a Novel Isocyanide-Based Multicomponent Reaction

Molecules, 2011
We have recently reported a novel multicomponent reaction between arylacetic acids and isocyanides, affording α-acyloxyacrylamides through an unusual mechanism.
Renata Riva, Andrea Basso, Luca Banfi
doaj   +1 more source

Model-driven Techniques for Data Model Synthesis [PDF]

Electronics, 2013
This article presents a survey of model-driven techniques for data model synthesis. During an extensive research,we identified more than 70 research papers in the field and more than 15 different graphical notations used for the source model ...
Drazen Brdjanin, Slavko Maric
doaj   +1 more source

Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation

Beilstein Journal of Organic Chemistry, 2013
An enantioselective synthesis of the core framework of neurotrophic Illicium majucin-type sesquiterpenes is described here. This strategy is based on an organocatalyzed asymmetric Robinson annulation and provides an efficient approach for a diversity ...
Lynnie Trzoss, Jing Xu, Michelle H. Lacoske, Emmanuel A. Theodorakis   +3 more
doaj   +1 more source

Synthesis of Lasofoxifene, Nafoxidine and Their Positional Isomers via the Novel Three-Component Coupling Reaction

Molecules, 2010
A Lewis acid-mediated three-component coupling reaction was successfully applied for the synthesis of lasofoxifene (1), nafoxidine (2), and their positional isomers, inv-lasofoxifene (3) and inv-nafoxidine (4).
Isamu Shiina, Kenya Nakata, Yoshiyuki Sano   +2 more
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Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea

Beilstein Journal of Organic Chemistry, 2019
A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed.
Aleksandr I. Kobelev, Nikita A. Tretyakov, Ekaterina E. Stepanova, Maksim V. Dmitriev, Michael Rubin, Andrey N. Maslivets   +5 more
doaj   +1 more source