Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β. [PDF]
ACS Med Chem Lett, 2016 Traditional fragment-based drug discovery (FBDD) relies heavily on structural analysis of the hits bound to their targets. Herein, we present a complementary approach based on diversity-oriented synthesis (DOS).
Wang Y +14 more
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Diversity-Oriented Synthetic Strategies Applied to Cancer Chemical Biology and Drug Discovery [PDF]
Molecules, 2014 How can diversity-oriented strategies for chemical synthesis provide chemical tools to help shape our understanding of complex cancer pathways and progress anti-cancer drug discovery efforts?
Ian Collins, Alan M. Jones
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Beilstein Journal of Organic Chemistry, 2012 Two-directional synthesis represents an ideal strategy for the rapid elaboration of simple starting materials and their subsequent transformation into complex molecular architectures.
Kieron M. G. O’Connell +3 more
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Diversity-Oriented Synthesis and Chemoinformatic Analysis of the Molecular Diversity of sp3-Rich Morpholine Peptidomimetics [PDF]
Frontiers in Chemistry, 2018 Diversity-Oriented Synthesis (DOS) consists of generating structurally diverse compounds from a complexity-generating reaction followed by cyclization steps and appendage diversity.
Elena Lenci +3 more
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Diversity-Oriented Synthesis: Amino Acetophenones as Building Blocks for the Synthesis of Natural Product Analogs [PDF]
Pharmaceuticals, 2021 Diversity-Oriented Synthesis (DOS) represents a strategy to obtain molecule libraries with diverse structural features starting from one common compound in limited steps of synthesis.
Mathias Eymery +2 more
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Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides [PDF]
Nature Communications, 2023 Liam Hudson +33 more
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Mask and Release Strategy‐Enabled Diversity‐Oriented Synthesis for DNA‐Encoded Library [PDF]
Advanced ScienceAn ideal DNA‐encoded library (DEL) selection requires the library to consist of diverse core skeletons and cover chemical space as much as possible. However, the lack of efficient on‐DNA synthetic approaches toward core skeletons has greatly restricted ...
Silin Zhang +9 more
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Diversity-Oriented Synthesis and Optical Properties of Bichromophoric Pyrrole-Fluorophore Conjugates [PDF]
Frontiers in Chemistry, 2018 The mild reaction conditions of the palladium-copper coupling-isomerization reaction open a highly convergent, chromogenic route to blue emissive pyrroles in the sense of a consecutive four-component reaction.
Oliver Grotkopp +2 more
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Diversity oriented synthesis for novel anti-malarials. [PDF]
Syst Synth Biol, 2015 Malaria a global pandemic has engulfed nearly 0.63 million people globally. It is high time that a cure for malaria is required to stop its ever increasing menace. Our commentary discusses the advent and contribution of diversity oriented synthesis (DOS) in the drug discovery efforts towards developing cure for malaria.
Bathula C, Singh S, Sen S.
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Diversity-Oriented Approaches toward the Synthesis of Cyclophanes
ACS OmegaHere, we describe synthetic approaches to a variety of cyclophanes involving transition-metal-catalyzed reactions such as the Suzuki-Miyaura cross-coupling, olefin metathesis, enyne metathesis, Glaser-Eglinton coupling, Yamamoto coupling, etc. On several occasions, alkylation, benzylation, Grignard reagents, and potassium thioacetate have been used for
Sambasivarao Kotha, Milind Meshram
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