Results 61 to 70 of about 5,221,708 (260)
Synthesis of (−)-julocrotine and a diversity oriented Ugi-approach to analogues and probes
Beilstein Journal of Organic Chemistry, 2011 An improved total synthesis of (−)-julocrotine in three steps from Cbz-glutamine, in 51% overall yield, is presented. To demonstrate the potential of the heterocyclic moiety for diversity oriented synthesis, a series of (−)-julocrotine analogues was ...
Ricardo A. W. Neves Filho +2 more
doaj +1 more source
Entropy‐Driven Design of Low‐Melting‐Point Alloys via Compositionally Complex Strategy
Advanced Engineering Materials, EarlyView.Conventional low‐melting‐point alloys (LMPAs) are limited by a narrow compositional space and inherent property trade‐offs. This review presents an entropy‐driven design strategy that overcomes these limitations, ushering in a new class of low‐melting‐point compositionally complex alloys (LMCCAs).
Yinghui Shang +6 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2015 A concise synthetic approach to a class of biologically interesting cyclic tetrapeptides is reported which involves a late-stage functionalization of a macrocyclic scaffold through cross metathesis in an attempt to create diversity.
Jyotiprasad Mukherjee +2 more
doaj +1 more source
Molecules, 2011 We are currently witnessing a decline in the development of efficient new anticancer drugs, despite the salient efforts made on all fronts of cancer drug discovery.
Andreas G. Tzakos +5 more
doaj +1 more source
FastNano Liquid: An Automated Platform for Small‐Angle X‐ray Scattering‐Based Materials Discovery
Advanced Engineering Materials, EarlyView.We present FastNano Liquid, an automated small‐ and wide‐angle X‐ray scattering platform for the combined synthesis and characterization of (nano)materials. The platform is coupled to varied reactor workflows for both in situ studies of reaction kinetics and ex situ screening of synthesis conditions to support machine learning‐guided exploration ...
Pierre‐Baptiste Flandrin +16 more
wiley +1 more source
, 2017 Diversity-oriented synthesis of coumarin-linked benzimidazoles from N-(2-aminophenyl)-2-cyanoacetamide was achieved via a one-pot, three-step sequential reaction in excellent yields.
Yu-Li Liu (175348) +5 more
core +1 more source
Advanced Functional Materials, EarlyView.Sulfur fluoride exchange (SuFEx) is a powerful click platform, yet water‐compatible multifunctional linchpins remain elusive. Here, we report decagram‐scalable diazonium linchpins that enable rapid Pd‐catalyzed diversification and direct, catalyst‐free on‐DNA ligation in aqueous media.
Seok Ju Hong +5 more
wiley +1 more source
Contemporary Applications of Chemical Libraries for Drug Discovery and Methods for Their Synthesis
ChemistryEuropeChemical libraries underpin contemporary drug discovery by enabling systematic exploration of chemical space for ligands. This review summarizes practical principles for designing, comparing, and selecting libraries, emphasizing how “diversity” can be ...
Tobias N. Hansen, Nils J. V. Hansen
doaj +1 more source
Stereodivergent Diversity Oriented Synthesis of Piperidine Alkaloids
European Journal of Organic Chemistry, 2006 AbstractAlkylidenetitanium reagents enable the reagent‐controlled high throughput asymmetric synthesis of 2‐substituted piperidines and rapid access to multiple cyclic imines using solid phase synthesis (SPS). The Schrock carbenes, generated by reduction of thioacetals, convert resin‐bound esters into enol ethers.
Louis Adriaenssens +4 more
openaire +3 more sources
A diversity oriented synthesis of natural product inspired molecular libraries
, 2017 Diversity oriented synthesis of natural product inspired compounds from S-tryptophan methyl ester.
Ulrike Holzgrabe +5 more
core +1 more source