Results 91 to 100 of about 1,768,757 (251)

Two step Steffensen-type methods with or without memory for nondifferentiable equations

open access: yesJournal of Numerical Analysis and Approximation Theory
A wide range of applications emerging from diverse disciplines are formulated as an equation or system of equations in abstract spaces such as Euclidean multidimensional, Hilbert or Banach to mention a few, a plethora of which are nondifferentiable ...
Ioannis K. Argyros, Gagan Deep
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Decay properties of spatial molecular orbitals

open access: yesResults in Applied Mathematics
Using properties of the Fourier transform we prove that if a Hartree–Fock molecular spatial orbital is in L1(R3), then it decays to zero as its argument diverges to infinity. The proof is rigorous, elementary and short.
Richard A. Zalik
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

A characterization of the weights in a divided difference [PDF]

open access: yesPacific Journal of Mathematics, 1981
Newman, D. J., Rivlin, T. J.
openaire   +3 more sources

Divided differences and multivariate holomorphic calculus

open access: yesDocumenta Mathematica
We review the multivariate holomorphic functional calculus for tuples in a commutative Banach algebra and establish a simple “naïve” extension to commuting tuples in a general Banach algebra. The approach is naïve in the sense that the naïvely defined joint spectrum maybe too big.
Luiz Hartmann, Matthias Lesch
openaire   +2 more sources

Convergence Conditions for the Secant Method

open access: yesCubo, 2010
We provide new sufficient convergence conditions for the convergence of the Secant method to a locally unique solution of a nonlinear equation in a Banach space.
Ioannis K Argyros   +1 more
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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