Results 81 to 90 of about 553,317 (257)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
الإيضاح, 2017 Almighty Allah created the man, endowed him with intellect and raised prophets among humanity for guidance. The scriptures were revealed by him which contained Divine commandments.
Ghulam Mustafa , Ehsan ur Rahman Ghouri
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Ethics and Aesthetics in the Song of Songs
Tyndale Bulletin, 1994 While readings of the Song of Songs tend to focus on the extent of its licencing of pre-marital sex, the Song’s message on the nature of sexual and human loving is to be found in its choice of metaphors for that activity.
Mark W. Elliott
doaj +1 more source
Świadectwo Boga Ojca o Jezusie w Ewangelii wg św. Jana
Verbum Vitae, 2015 The article addresses the issue of the witness of the Father about Jesus in the Fourth Gospel. The topic is inscribed in the very essential theological message of the Gospel of John, according to which Jesus is the Messiah and the Son of God revealing ...
Janusz Kręcidło
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Quantifying the Discord: Order Discrepancies in Message Sequence Charts
, 2007 Message Sequence Charts (MSCs) and High-level Message Sequence Charts (HMSC) are formalisms used to describe scenarios of message passing protocols. We propose using Allen's logic to study the temporal order of the messages. We introduce the concept of {\
Genest, Blaise +7 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source