Results 51 to 60 of about 5,244 (249)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Revista Cubana de Estomatología, 2012 La belleza y la armonía facial desempeñan una función decisiva en las relaciones sociales del hombre. La afectación estética es el principal motivo de consulta de los pacientes de Ortodoncia.
Yaima Lazo Amador +3 more
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
DIVINE PROPORTION IN MODERN ARCHITECTURE: A CASE STUDY
Jurnal Teknologi, 2016 Mathematics and architecture are interrelated. A building with the appropriate mathematical elements in its design will be impressive in its appearance. One of the most widely used mathematical proportions in architecture is divine proportion, or better known as φ ( with Fn the n-th Fibonacci sequence).
Marina Mohamed +4 more
openaire +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Influence Néoplatonicienne et « divine proportion » chez Léonard de Vinci
Arts et Sciences, 2022 Annalisa Di Maria +2 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Critical Analysis of the Misgivings of the Book “A Critical Review of the Theoretical Fundamentals of Prophecy” on the Language of the Quran [PDF]
آموزههای قرآنیIn recent years, some dissident authors, including the author of A Critical Review of the Theoretical Fundamentals of Prophecy have presented critical questions and new misgivings about the topics of the language of the Holy Quran by radical and ...
Hamid Qorbanpour Lafmejani +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source