Results 71 to 80 of about 5,244 (249)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Divine proportion in patients with skeletal occlusion classes I, II and III on lateral cephalometric radiographs

Revista Cubana de Estomatología, 2014
Introduction: the original concept of beauty refers to a set of harmony and balance features determined by bone, dental and soft tissue. Objective: the purpose of this study was to analyze divine proportion as reflected on cephalometric radiographs of ...
Priscila Tomaz Toniello, Mariliani Chicarelli da Silva, Lilian Cristina Vessoni Iwaki, Maria Gisette Arias Provenzano, Wilton Mitsunari Takeshita   +4 more
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Analysis of the relation between the golden ratio and the facial parameter

Revista Cubana de Estomatología, 2018
Introduction: the clinical ability to modify the dentofacial form through orthodontic treatment, maxillofacial surgery, or plastic surgery requires an understanding of facial beauty, including the evaluation of facial aesthetics, proportions, and ...
Melissa Andrea Díaz Salés, Luis Oscar Pacheco Fernández, Mariano Ortiz Pizarro, María Elizabeth Cruz Flores, Rosse Mary Falcón-Antenucci   +4 more
doaj  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Proporção divina em indivíduos oclusões classes I, II e III esqueléticas em radiografias cefalométricas laterais

Revista Cubana de Estomatología
Introdução: o conceito inicial de beleza remete a um conjunto que engloba harmonia e equilíbrio das proporções faciais estabelecidas pelas estruturas esqueléticas, dentárias e de tecidos moles.
Priscila Tomaz Toniello, Mariliani Chicarelli da Silva, Lilian Cristina Vessoni Iwaki, María Gisette Arias Provenzano, Wilton Mitsunari Takeshita   +4 more
doaj  

Modeling spiritual aspects in the formation of a perfect family among B40 Group society

Cogent Arts & Humanities
The paper examines the impact of spiritual aspects on the formation of a perfect family among the B40 group in Kuala Langat and Hulu Langat, Selangor, Malaysia and determines the relationship between religious beliefs and factors contributing to family ...
Nurulain Nabilah Muhammad Aris Fadzilah, Ong Wen Xuan, Lim Chui Ting, Nora Muda   +3 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Relación entre la proporción áurea y el índice facial en estudiantes de Estomatología de La Habana Relation between the aureal proportion and the facial index in students of Stomatology of La Habana

Revista Cubana de Estomatología, 2010
La proporción áurea ha sido utilizada en el diagnóstico ortodóncico como una variable importante para decidir el tratamiento de elección. Objetivo: evaluar la relación entre la presencia de la proporción divina y el tipo facial morfológico.
Alberto E Companioni Bachá, Alicia Torralbas Velázquez, Carlos Sánchez Mesa   +2 more
doaj