Results 51 to 60 of about 907 (238)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Repairing the Contingency Argument against Divine Simplicity
, 2021 According to classical theism, God is simple. However, contemporary objections to divine simplicity abound. One of those objections has received a lot of attention recently: the contingency objection.
Collier, Matthew James
core +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Divine simplicity as actus purus [PDF]
, 2005 This thesis presents a case for the traditional doctrine of divine simplicity by construing it along the lines that God exists as actus purus. My formulation of divine simplicity draws upon the medieval insight that God is what He is in virtue of what ...
Gehring, Allen Stanley, Jr.
core
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
MarifetnameThis article investigates the proof of God’s existence within Ibn Sīnā’s metaphysical framework, particularly addressing the concepts of divine simplicity and the problem of modal collapse.
Tugay Taşçı
doaj +1 more source
Divine simplicity : a dogmatic account
, 2014 This thesis offers a constructive account of the doctrine of divine simplicity in Christian theology. In its methodology, the thesis aims to present this divine perfection as an implicate of the scriptural portrayal of God, to draw upon the insights and
Duby, Steven J.
core
Divine Simplicity and Naming God
, 2023 This essay explores the doctrine of divine simplicity (DDS) within the framework of classical theism, addressing its compatibility with the plurality of divine attributes.
Martin, Michael
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source