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Sclerostin and DKK1 in Primary Hyperparathyroidism

open access: yesCalcified Tissue International, 2013
Bone formation is influenced by the Wnt pathway through effects on osteoblast functionality, and these actions are opposed by two antagonists: sclerostin and Dickkopf-1 (DKK1). Decreased levels of serum sclerostin were found after treatment with the PTH analogue teriparatide and in patients with primary hyperparathyroidism (PHPT), while treatment with ...
VIAPIANA, Ombretta   +6 more
openaire   +3 more sources
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Mutation analysis of DKK1 and in vivo evidence of predominant p53-independent DKK1 function in gliomas

Acta Neuropathologica, 2005
DKK1 protein belongs to a family of inhibitors of the Wnt/beta1-catenin signaling pathway. Sporadic mutations affecting almost each major player of the Wnt/beta1-catenin pathway have been described in a variety of human carcinomas. DKK1 translation can be induced by p53, thereby linking TP53 and Wnt/beta1-catenin signaling pathways.
Sven Wellmann   +2 more
exaly   +3 more sources

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