Results 181 to 190 of about 18,876 (219)

DKK1 is highly expressed in the dermis of vitiligo lesion: Is there association between DKK1 and vitiligo?

Journal of Dermatological Science, 2012
Ji Young Kim, Sang Ho Oh, Seung-Kyung Hann   +2 more
exaly   +3 more sources

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Cells, 2021
Androgenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered.
Nino Rcheulishvili, Dimitri Papukashvili, Cong Liu   +2 more
exaly   +2 more sources

DKK1 is a strong candidate for mesiodens and taurodontism

Clinical Genetics, 2023
A mutation in DKK1 gene leads to inhibitory DKK1 function, over-activation of WNT/β-catenin signaling, disruptive development of dental epithelium, and subsequent mesiodens formation.
Piranit Kantaputra, Peeranat Jatooratthawichot, Naomi Kottege, Robert P. Anthonappa, Massupa Kaewgahya, Sissades Tongsima, Chumpol Ngamphiw, James R. Ketudat Cairns, Danilo Predes, Xi He   +9 more
openaire   +2 more sources

Comparative genomics on Dkk1 orthologs

International Journal of Oncology, 2005
WNT family proteins bind to transmembrane proteins FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, FZD10, LRP5, LRP6, ROR1, ROR2, RYK, and also secreted proteins SFRP1, SFRP2, SFRP3, SFRP4, SFRP5, and DAND4 (CER1). DKK family members antagonize WNT binding to LRPs, while SFRP family members antagonize WNT binding to FZDs.
Yuriko, Katoh, Masaru, Katoh
openaire   +2 more sources

Converging on DKK1 to drive metastasis

Science, 2020
Cancer Hepatocellular carcinoma (HCC) is a common form of liver cancer. The Wnt signaling protein Dickkopf-1 (DKK1) and epidermal growth factor receptor (EGFR) are both associated with metastatic progression and poor prognosis in HCC patients. Niu et al. found that these molecular markers are linked.
openaire   +1 more source

Expression, purification and characterization of murine Dkk1 protein

Protein Expression and Purification, 2008
Dickkopf-1 (Dkk1) protein is a secreted inhibitor of canonical Wnt signaling and modulates that pathway during embryonic development. It is also implicated in several diseases and hence Dkk1 is a potential target for therapeutic intervention. In the present study 6His-tagged Dkk1 expression and secretion was assessed in five mammalian cell types.
Damien, Fleury, Corinne, Gillard, Helène, Lebhar, Béatrice, Vayssière, Robert, Touitou, Georges, Rawadi, Patrick, Mollat   +6 more
openaire   +2 more sources

Increased Levels of DKK1 in Vitreous Fluid of Patients with Pathological Myopia and the Correlation between DKK1 Levels and Axial Length

Current Eye Research, 2019
Purpose: Dickkopf 1 (DKK1) functions as a natural antagonist of the canonical Wnt/β-catenin pathway. The purpose of this study was to examine the expression of DKK1 in vitreous samples of patients with pathological myopia, in order to search for possible correlations between DKK1 and axial length.Materials and Methods: The expression of DKK1 and other ...
Manjuan, Peng, Yantao, Wei, Zhaotian, Zhang, Ting, Zhang, Suo, Qiu, Dong, Fang, Li, Wang, Shaochong, Zhang   +7 more
openaire   +2 more sources

Dkk1: A promising molecule to connect Alzheimer’s disease and osteoporosis

Medical Hypotheses, 2016
Osteoporosis and Alzheimer's disease (AD) are the two common diseases mostly affecting persons aged over 60. Epidemiological findings revealed that osteoporosis and AD have a very high comorbidity. However, the mechanisms underlying their association are poorly understood.
Xingzhi, Guo, Peng, Tang, Peng, Liu, Yue, Liu, Li, Chong, Rui, Li   +5 more
openaire   +2 more sources

Significance of Serum DKK1 as a Diagnostic Biomarker in Hepatocellular Carcinoma

Future Oncology, 2012
Hyperactivation of the Wnt/β-catenin signaling pathway has been implicated in cancers, including hepatocellular carcinoma (HCC). Dickkopf-1 (DKK1) is a secretory antagonist of the Wnt/β-catenin signaling pathway and has been found to be upregulated in many cancer types.
Edmund Kwok-Kwan, Tung, Irene Oi-Lin, Ng
openaire   +2 more sources

Correlations of DKK1 with pathogenesis and prognosis of human multiple myeloma

Cancer Biomarkers, 2019
OBJECTIVE: Human multiple myeloma (MM) is a kind of common tumor in middle-aged and elderly people, in which the osteolytic lesion is formed mainly through inhibiting osteoblast (OB) differentiation and promoting osteoclast (OC) differentiation. Dickkopf-1 (DKK1) is a soluble Wnt inhibitor, which has an important correlation with the pathogenesis of ...
Youfan, Feng, Yuxia, Zhang, Xiaofang, Wei, Qike, Zhang   +3 more
openaire   +2 more sources