Results 101 to 110 of about 11,296 (218)

Inhibition of kynurenine 3‐monooxygenase (KMO) reduces fentanyl and sucrose intake and relapse‐like behaviour in rats

British Journal of Pharmacology, Volume 183, Issue 18, Page 5458-5475, September 2026.
Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle, Lluna Careaga, Stefanie Malan‐Müller, Álvaro del Río‐García, Yaiza Trueba, Leticia Gil de Biedma‐Elduayen, Nuria Morales‐Puerto, Rebeca Vidal, Åsa Wiman, Sophie Erhardt, María Dolores Gutiérrez‐López, Esther O'Shea, María Isabel Colado   +12 more
wiley   +1 more source

Conditional Gains: When AI Investment Enhances Firm Efficiency

Scottish Journal of Political Economy, Volume 73, Issue 4, September 2026.
ABSTRACT The rapid adoption of artificial intelligence (AI) has raised questions about its effect on firm performance. Using a labor‐based measure of AI investment, the baseline results show no direct association between AI investment and firm efficiency.
Pantelis Kazakis
wiley   +1 more source

Unique transcriptomic alterations in 5XFAD;PS19 mouse model identify glial lipid dysregulation and coordinated microglial–oligodendrocyte responses

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) features amyloid beta (Aβ) plaques and tau tangles, yet how their coexistence reshapes brain transcriptomic programs remains unclear. METHODS We performed high‐quality, sex‐balanced single‐nucleus RNA sequencing of 5XFAD (Aβ), PS19 (tau), and combined 5XFAD;PS19 mice.
Jung Hyun Park, Byungwook Kim, Md Mamun Al‐Amin, Mason Douglas Tate, Ahmad Daniel Sharify, Sutha K. John, Hande Karahan, Hui‐Chen Lu, Luke Child Dabin, Jungsu Kim   +9 more
wiley   +1 more source

Evaluation of a Product Intended for Microbiological Control in Animal Production, and Its Combination With Halquinol

Animal Research and One Health, Volume 4, Issue 3, Page 302-313, August 2026.
Activo Liquid and Halquinol inhibit Salmonella and Escherichia coli in culture media. Activo Liquid exhibits bactericidal action, whereas HA is bacteriostatic, and their combination results in positive or indifferent interactions. This combination effectively inhibits E. coli throughout digestion simulation, thus reducing the required concentrations of
Alberto Gonçalves Evangelista, Lucas dos Santos Janotto, Adriana Paula Possamai, Carolina Cini Perry, Francine Lemes Ribeiro, Rafael Canonenco de Araujo, Fernando Bittencourt Luciano   +6 more
wiley   +1 more source

Treatment of a Large Cohort of Childhood Chronic Noninfectious Uveitis in a Multicentric Large Study: Adalimumab Versus Methotrexate as First‐Line Therapy

Arthritis &Rheumatology, Volume 78, Issue 8, Page 1789-1797, August 2026.
Objective Treatment of childhood chronic idiopathic uveitis (cCIU) is predominantly based on studies in juvenile idiopathic arthritis–associated uveitis and expert opinion. Our aim was to report the treatment outcomes of our cohort of cCIU. Methods Retrospective multicenter study involving the rheumatology and ophthalmology units at Florence, Italy ...
Ilaria Maccora, Catherine Guly, Cinzia de Libero, Giulia Carreras, Athimalaipet V. Ramanan, Gabriele Simonini   +5 more
wiley   +1 more source

Early Upper Limb Motor Impairment in Multiple Sclerosis Across EDSS Levels: A Case–Control Study

Brain and Behavior, Volume 16, Issue 8, August 2026.
Upper limb function is impaired in people with multiple sclerosis compared with healthy controls, even at low levels of neurological disability. Patients are stratified by Expanded Disability Status Scale (EDSS) score (≤3.5 and >3.5) and assessed using objective upper limb measures.
Aitor Blázquez‐Fernández, Selena Marcos‐Antón, Cecilia Estrada‐Barranco, Patricia Martín‐Casas, Rosa María Ortiz‐Gutiérrez, Carmen Jiménez‐Antona, Sofía Laguarta‐Val, Roberto Cano‐de‐la‐Cuerda   +7 more
wiley   +1 more source

Using Machine Learning to Automate the Analysis of an Olfactory Habituation‐Dishabituation Task in Mice

Brain and Behavior, Volume 16, Issue 8, August 2026.
Workflow of DeepLabCut and SimBA pipeline for analysis of olfactory habituation‐dishabituation task in mice. ABSTRACT Introduction Improving the efficiency and accuracy of annotation and extraction of performance data from mouse behavioral tasks will improve both the throughput and scientific value of preclinical research.
S. Boyanova, M. H. Correa, R. S. Bains, F. K. Wiseman   +3 more
wiley   +1 more source

Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin, Bishnu Prasad Pandey, Satyajit Mohanty, Rupsa Mondal, Abanish Biswas, Ashok Kumar Pattnaik, Subodh Mondal, Vinay N. Basavanakatti, Nilüfer Bayrak, Venkatesan Jayaprakash, Hoon Kim, Amaç Fatih TuYuN   +11 more
wiley   +1 more source

Chiroptera Personality—A Guide for Assessing Personality Variation in Bats: Ecological, Methodological and Statistical Considerations

Ecology and Evolution, Volume 16, Issue 8, August 2026.
This paper addresses the underrepresentation of bats in animal personality research despite their ecological importance, offering a structured guide for studying consistent individual behavioural differences in this taxon. We outline key experimental, fieldwork and annotation considerations specific to bats' unique life histories, alongside a five‐step
Theresa Schabacker, Mirjam Knörnschild
wiley   +1 more source

Dose‐Dependent Anti‐Obesity and Protective Effects of Chia (Salvia hispanica L.) Seed Oil Against Hematological and Hepatorenal Dysfunction in High‐Fat Diet–Fed Mice

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Chia seed oil ameliorates obesity, dyslipidemia, and hepatorenal dysfunction in high‐fat diet–fed mice. ABSTRACT Chia seeds (Salvia hispanica L.) are recognized as a functional food with a nutrient‐dense profile and health‐promoting properties. In the present study, hexane‐extracted chia seed oil was investigated for anti‐obesity, hematoprotective, and
Sabbya Sachi, Mst. Prianka Jahan, Sree Alok Kumar, Mahmudul Hasan Sikder, Md. Zahorul Islam   +4 more
wiley   +1 more source