Results 191 to 200 of about 15,452 (227)

Discovery of a pre-vein progenitor that requires VEGF/ERK inhibition to complete vein differentiation

Ang LT, Zheng SL, Liu KJ, Masaltseva A, Winters J, von Creytz I, Jha SK, Yin Q, Qian C, Xiong X, Dailamy A, Xi E, Alcocer JC, Sorensen DW, She R, Smolyar K, Szumska D, Nornes S, Martin RM, Lesch BJ, Restrepo NK, Sun W, Weissman JS, Lickert H, Porteus MH, Skylar-Scott MA, Mosimann C, Sumanas S, Val SD, Prescott JB, Red-Horse K, Loh KM.   +31 more
europepmc   +1 more source

Dll4 and Notch signalling couples sprouting angiogenesis and artery formation [PDF]

Nature Cell Biology, 2017
Endothelial sprouting and proliferation are tightly coordinated processes mediating the formation of new blood vessels during physiological and pathological angiogenesis. Endothelial tip cells lead sprouts and are thought to suppress tip-like behaviour in adjacent stalk endothelial cells by activating Notch.
Urs Hanno Langen, Takashi Nagasawa, Napoleone Ferrara   +2 more
exaly   +5 more sources

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Chronic DLL4 blockade induces vascular neoplasms

Nature, 2010
Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising ...
Minhong, Yan, Christopher A, Callahan, Joseph C, Beyer, Krishna P, Allamneni, Gu, Zhang, John Brady, Ridgway, Kyle, Niessen, Greg D, Plowman   +7 more
openaire   +2 more sources

Expression pattern of Dll4 during chick embryogenesis

Histochemistry and Cell Biology, 2007
Notch and Delta signaling regulates cell-fate decisions in a variety of tissues in diverse organisms through cell-to-cell interactions. In this study we isolated a 696 bp fragment of chick Delta-like 4 (Dll4) cDNA and analyzed its expression pattern during chick development by in situ hybridization.
Nimmagadda, Suresh, Geetha Loganathan, Poongodi, Pröls, Felicitas, Scaal, Martin, Christ, Bodo, Huang, Ruijin   +5 more
openaire   +3 more sources

Dll4: “Notch” Your Normal Pathway

The FASEB Journal, 2017
The rising threat of nuclear terrorism necessitates proactive research to mitigate injury by radiation. Since one of the most damaging effects of radiation is the reduction of small blood vessels in healthy tissue, radiation‐induced organ damage may be lessened by increasing blood vessel density.
Emily Barmantje, Erica Nelson, Aayush Agrawal, Smrithi Chanjeevaram, Aditya Jhaveri, Michelle Lazar, Katrina Li, Darby McManus, Nikhita Santebennur, Mia Schlidt, Meetha Medhora   +10 more
openaire   +1 more source

Abstract A19: Potent antitumor activity of Dll4 blockade in ovarian xenografts mediated by blocking stromal Dll4

Molecular Cancer Therapeutics, 2015
Abstract The Notch ligand delta-like 4 (Dll4) has been identified as a promising new target in tumor angiogenesis in preclinical studies, and Dll4 inhibitors have recently entered clinical trials for solid tumors, including ovarian cancers.
Frank Kuhnert, Guoying Chen, Sandra Coetzee, Jessica Kirshner, Gavin Thurston   +4 more
openaire   +1 more source

Dll4-Notch signaling in regulation of tumor angiogenesis

Journal of Cancer Research and Clinical Oncology, 2013
Tumor angiogenesis is a complex process and involves the tight interplay of tumor cells, endothelial cells, phagocytes and their secreted factors, which may act as promoters or inhibitors of angiogenesis. Many signaling pathways involved in these processes such as vascular endothelial growth factor (VEGF), fibroblast growth factors, Wnt and mTOR ...
Zhaoguo, Liu, Fangtian, Fan, Aiyun, Wang, Shizhong, Zheng, Yin, Lu   +4 more
openaire   +2 more sources

The endothelial Dll4–muscular Notch2 axis regulates skeletal muscle mass

Nature Metabolism, 2022
Adult skeletal muscle is a highly plastic tissue that readily reduces or gains its mass in response to mechanical and metabolic stimulation; however, the upstream mechanisms that control muscle mass remain unclear. Notch signalling is highly conserved, and regulates many cellular events, including proliferation and differentiation of various types of ...
Shin Fujimaki, Tomohiro Matsumoto, Masashi Muramatsu, Hiroshi Nagahisa, Naoki Horii, Daiki Seko, Shinya Masuda, Xuerui Wang, Yoko Asakura, Yukie Takahashi, Yuta Miyamoto, Shingo Usuki, Kei-ichiro Yasunaga, Yasutomi Kamei, Ryuichi Nishinakamura, Takashi Minami, Takaichi Fukuda, Atsushi Asakura, Yusuke Ono   +18 more
openaire   +2 more sources

The Prediction of DLL4 as a Prognostic Biomarker in Patients with Gastric Cancer Using Anti-DLL4 Nanobody

Journal of Gastrointestinal Cancer
Angiogenesis and cancer metastasis depend on the DLL4/Notch signaling pathway. A new approach to treating angiogenesis could inhibit or block this pathway. In the present study, we investigated DLL4 expression as a biomarker capable of predicting survival outcomes in gastric cancer patients using a novel anti-DLL4 Nanobody.By using a recently developed
Reza, Afzalipour, Tannaz, Abbasi-Dokht, Maryam, Sheikh, Maryam, Mohammadlou, Fatemeh, Nili, Rasoul, Baharlou   +5 more
openaire   +2 more sources