Results 201 to 210 of about 15,361 (230)
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The endothelial Dll4–muscular Notch2 axis regulates skeletal muscle mass
Nature Metabolism, 2022Adult skeletal muscle is a highly plastic tissue that readily reduces or gains its mass in response to mechanical and metabolic stimulation; however, the upstream mechanisms that control muscle mass remain unclear. Notch signalling is highly conserved, and regulates many cellular events, including proliferation and differentiation of various types of ...
Shin Fujimaki +2 more
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Expression pattern of Dll4 during chick embryogenesis
Histochemistry and Cell Biology, 2007Notch and Delta signaling regulates cell-fate decisions in a variety of tissues in diverse organisms through cell-to-cell interactions. In this study we isolated a 696 bp fragment of chick Delta-like 4 (Dll4) cDNA and analyzed its expression pattern during chick development by in situ hybridization.
Nimmagadda, Suresh +5 more
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Dll4: “Notch” Your Normal Pathway
The FASEB Journal, 2017The rising threat of nuclear terrorism necessitates proactive research to mitigate injury by radiation. Since one of the most damaging effects of radiation is the reduction of small blood vessels in healthy tissue, radiation‐induced organ damage may be lessened by increasing blood vessel density.
Emily Barmantje +10 more
openaire +1 more source
Molecular Cancer Therapeutics, 2015
Abstract The Notch ligand delta-like 4 (Dll4) has been identified as a promising new target in tumor angiogenesis in preclinical studies, and Dll4 inhibitors have recently entered clinical trials for solid tumors, including ovarian cancers.
Frank Kuhnert +4 more
openaire +1 more source
Abstract The Notch ligand delta-like 4 (Dll4) has been identified as a promising new target in tumor angiogenesis in preclinical studies, and Dll4 inhibitors have recently entered clinical trials for solid tumors, including ovarian cancers.
Frank Kuhnert +4 more
openaire +1 more source
Dll4-Notch signaling in regulation of tumor angiogenesis
Journal of Cancer Research and Clinical Oncology, 2013Tumor angiogenesis is a complex process and involves the tight interplay of tumor cells, endothelial cells, phagocytes and their secreted factors, which may act as promoters or inhibitors of angiogenesis. Many signaling pathways involved in these processes such as vascular endothelial growth factor (VEGF), fibroblast growth factors, Wnt and mTOR ...
Zhaoguo, Liu +4 more
openaire +2 more sources
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
Nature, 2006Haploinsufficiency of Dll4, a vascular-specific Notch ligand, has shown that it is essential for embryonic vascular development and arteriogenesis. Mechanistically, it is unclear how the Dll4-mediated Notch pathway contributes to complex vascular processes that demand meticulous coordination of multiple signalling pathways.
Minhong Yan
exaly +3 more sources
Journal of Gastrointestinal Cancer
Angiogenesis and cancer metastasis depend on the DLL4/Notch signaling pathway. A new approach to treating angiogenesis could inhibit or block this pathway. In the present study, we investigated DLL4 expression as a biomarker capable of predicting survival outcomes in gastric cancer patients using a novel anti-DLL4 Nanobody.By using a recently developed
Reza, Afzalipour +5 more
openaire +2 more sources
Angiogenesis and cancer metastasis depend on the DLL4/Notch signaling pathway. A new approach to treating angiogenesis could inhibit or block this pathway. In the present study, we investigated DLL4 expression as a biomarker capable of predicting survival outcomes in gastric cancer patients using a novel anti-DLL4 Nanobody.By using a recently developed
Reza, Afzalipour +5 more
openaire +2 more sources
Dll1 and Dll4: similar, but not the same
Blood, 2009The VEGF-Dll4-Notch1 signaling cascade has taken center stage in angiogenesis, but it now appears that Dll1 ligands have precedence in arteries and even seem to control VEGF signaling.
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The Clinicopathological Significance of Jagged1 and DLL4 in Gallbladder Cancer
Tumori Journal, 2016Purpose Gallbladder cancers (GBCs) are highly aggressive gastrointestinal cancers with high mortality. Biological markers for the diagnosis, prognosis, and targeted therapy of GBCs have not been established. Methods The protein expression of Jagged1 and DLL4 in 80 adenocarcinomas (AC) and 46 squamous cell/adenosquamous carcinomas (SC/ASCs) was measured
Yuan, Luo +10 more
openaire +2 more sources
The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development
Blood, 2011AbstractThe Notch signaling pathway plays a fundamental role during blood vessel development. Notch signaling regulates blood vessel morphogenesis by promoting arterial endothelial differentiation and pro-viding spatial and temporal control over “tip cell” phenotype during angiogenic sprouting.
Kyle, Niessen +6 more
openaire +2 more sources