Results 211 to 220 of about 15,361 (230)

Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles

Gene Expression Patterns, 2005
Delta-Notch signalling regulates cell-fate decisions in a variety of tissues in diverse organisms, through cell-to-cell interactions. Here, we report the expression pattern of a Delta gene family member, Delta-like 4 (Dll4). Dll4 expression was analyzed in mouse embryos and selected adult organs by monitoring beta-galactosidase (beta-gal) expression ...
Rui, Benedito, António, Duarte
openaire   +2 more sources

DLL4/VEGF bispecific molecularly imprinted nanomissile for robust tumor therapy

Biomaterials
Tumor-induced angiogenesis plays a pivotal role in the progression and expansion of solid tumors, making anti-angiogenic therapies a promising strategy in cancer treatment. However, compensatory angiogenesis, which can drive drug resistance and tumor recurrence, poses significant challenges in anti-angiogenic therapy.
Fang Jin, Peixin Guan, Lingrui Huang, Anqi Zhang, Song Gao, Lisheng Wang, Zhen Liu   +6 more
openaire   +2 more sources

Dual inhibition of VEGF and DLL4 ameliorates anti-DLL4 cardiac endothelial hypertrophy in cynomolgus monkeys

Journal of Pharmacological and Toxicological Methods, 2016
Rene Meisner, Gretchen Argast, Yu-Wang Liu, Breanna Wallace, Min Wang, Ann Kapoun, Tim Hoey   +6 more
openaire   +1 more source

VEGF/DLL4 BINDING AGENTS AND USES THEREOF

2019
The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind ...
openaire   +1 more source

Perinatal angiogenesis from pre-existing coronary vessels via DLL4–NOTCH1 signalling

Nature Cell Biology, 2021
Pengfei Lu, Yang Liu, Deyou Zheng
exaly  

Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis

Nature Communications, 2020
Nan Wu, Jennifer S Fang, Ricardo N Ramirez   +2 more
exaly  

DLL4 and VCAM1 enhance the emergence of T cell–competent hematopoietic progenitors from human pluripotent stem cells

Science Advances, 2022
Yale S Michaels, John M Edgar
exaly  

Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis

Cell Death and Differentiation, 2020
Serena Mancarella, Grazia Serino, Francesco Dituri   +2 more
exaly  

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

Nature, 2007
Li-Kun Phng, Jennifer J Hofmann, Leigh Coultas   +2 more
exaly  

Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation

EMBO Journal, 2020
Cristina Porcheri, Fernando J Calero-Nieto, Roshana Thambyrajah   +2 more
exaly