Results 241 to 250 of about 107,340 (312)

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Bidirectional regulation of social memory by two distinct types of GABAergic neurons in the lateral septum. [PDF]

Nat Commun
Zhang L, Huang M, Ye CL, Tang Z, Xu M, Wang Y, Wang T, Luo S, Ji R, Yu C, Luo H, Cao P, Wu QF, Jiang M.   +13 more
europepmc   +1 more source

3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species

Advanced Science, EarlyView.
ABSTRACT Three‐dimensional (3D) chromatin architecture plays a fundamental role in eukaryotic gene regulations, its functional significance in perennial fruit trees remains poorly characterized despite extensive applications in crop genomics. Here, we developed high‐resolution (∼5 kb) Hi‐C maps of Pyrus and compared 3D genomic architecture of three ...
Yueyuan Liu, Chenhui Han, Cheng Xue, Manyi Sun, Bobo Song, Yongsong Xue, Guangyan Yang, Shaozhuo Xu, Wei Wei, Jiaming Li, Runze Wang, Jun Wu   +11 more
wiley   +1 more source

Use of the MOF NU-1000 as a Drug Delivery System for the Antineoplastic Drug Mitoxantrone. [PDF]

Int J Mol Sci
Alfonso DR, Moscoso FG, Rodríguez-Lucena D, Roales J, Carrillo-Carrión C, Cascajo-Almenara MV, Santos-Ocaña C, Pedrosa JM.   +7 more
europepmc   +1 more source

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

One-Pot Green Synthesis of Amino Acid-Capped Gold Nanoparticles for Selective Sensing of Cyanide and Heavy Metals. [PDF]

ACS Omega
Girgin B, Sözmen AB, Arslan-Yildiz A.
europepmc   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Empirical evaluation of variability and multi-institutional generalizability of deep learning survival models: application to renal cancer CT scans. [PDF]

Comput Biol Med
Flannery B, DeSilvio T, Hariri M, Sadri AR, Heller N, Weight C, Viswanath SE.   +6 more
europepmc   +1 more source

Ball Mill Beatdown: Mechanochemical Synthesis of TaON Nanocrystals. [PDF]

Inorg Chem
Stegner EK, Kuns MR, Ochoa-Romero K, Guirado G, Vela J.   +4 more
europepmc   +1 more source

Predictive Stability of Aggregation in Glycoconjugate Vaccines Using Advanced Kinetics Modeling and High-Throughput Screening. [PDF]

Pharmaceutics
Cui TJ, Clénet D, Capelle MAH, Opacic M.   +3 more
europepmc   +1 more source