Results 111 to 120 of about 76,642 (241)
Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender +17 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1650-1661, June 2026.AGILE (NCT04746183) is a Phase Ib/IIa platform, evaluating candidates to treat COVID‐19. Candidate Specific Trial 6 evaluated the safety and optimal dose of a novel intravenous formulation of favipiravir in a dose‐escalating, open‐label, randomized, controlled, Bayesian adaptive Phase Ib trial.
Tim Rowland +48 more
wiley +1 more source
International Journal of Cancer, Volume 158, Issue 11, Page 3038-3050, 1 June 2026.What's new? Pancreatic ductal adenocarcinoma is characterized by a dense extracellular matrix, and how invasive tumor cells overcome such biomechanical constraints remains unclear. This study identifies the actin‐related protein 2/3 complex as a key regulator of pancreatic ductal adenocarcinoma invasiveness, driving fibroblast migration through β1 ...
Xiufen Yang +15 more
wiley +1 more source
Musculoskeletal Care, Volume 24, Issue 2, June 2026.ABSTRACT Introduction Systemic Sclerosis (SSc) is associated with substantial disability in affected patients. Although exercise interventions for SSc have been developed, most focus on isolated body segments rather than global disability. Thus, this study aims to assess the feasibility of a functional activity‐based exercise programme designed to ...
Gabriela da Silva Santos +7 more
wiley +1 more source
The Prostate, Volume 86, Issue 8, Page 891-899, June 2026.ABSTRACT Background Further work is needed to improve treatment outcomes for prostate cancer (PCa), with the repurposing of the α1‐adrenoreceptor antagonists presenting a potential solution. This feasibility clinical trial presents the first prospective data of the use of an α1‐adrenoreceptor antagonist in men undergoing radiotherapy for PCa.
Liam D. King +8 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, Volume 20, Issue 5, Page 1115-1139, May 2026.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
ACR Open Rheumatology, Volume 8, Issue 5, May 2026.Objective The aim of this study was to evaluate the neutrophil‐to‐lymphocyte ratio (NLR) as an independent predictor of major adverse cardiovascular events (MACEs) and all‐cause mortality in patients with psoriasis (PsO) or psoriatic arthritis (PsA). Methods We conducted a retrospective cohort study of 967 patients (825 with PsO and 142 with PsA) at a ...
Mauro Martini +9 more
wiley +1 more source
One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy
Advanced Science, Volume 13, Issue 26, 8 May 2026.This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu +8 more
wiley +1 more source
Nucleation Kinetics Reveals a Distinct Biological Function Space of Biomolecular Condensates
Advanced Science, Volume 13, Issue 26, 8 May 2026.This study utilizes microfluidics to quantify the nucleation rates of dense liquid phases within dilute solutions and of the reverse process, in which dilute voids nucleate inside condensates. The interfacial tension is identified as the key determinant of both processes.
Leif‐Thore Deck +5 more
wiley +1 more source
Coaxial Placement of Fogarty Catheter: A Simple Remedy for Incomplete Lung Isolation with DLT
The Indian Anaesthetists' Forum, 2015 Thoracic surgery requires lung isolation which is usually achieved by placing a double lumen tube (DLT). Correct placement of DLT is crucial for lung isolation. In this case report incomplete lung isolation with DLT was corrected using a Fogarty catheter
Amit Kumar Mittal +4 more
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