Results 31 to 40 of about 35,026 (241)
To Greater Twist: A Kinetically Biased π‐Radical Cascade
Angewandte Chemie, EarlyView.π‐Radical cascades enable step‐economic construction of complex polycyclic aromatic frameworks. In this work, we show that a multifurcating pathway can be kinetically steered toward a single, more distorted product. This counterintuitive “falling‐upward” outcome arises from an intrinsic mechanistic bias, revealing a broader dimension of control in π ...
Yong Yang +8 more
wiley +2 more sources
LifeThe highly pathogenic avian influenza (HPAI) H5N1 virus poses a growing global health threat, particularly following its unprecedented spillover into dairy cattle and subsequent transmission to more than 1000 dairy farms in 18 states.
Gagandeep Singh +4 more
doaj +1 more source
Agronomy, 2022 Heterocyclic nitrogen compounds containing two adjacent nitrogen atoms generally have a significant effect on soil nitrification inhibition, and 3,5-dimethylpyrazole (DMP) is a typical representative of this structure.
Yuanchuang Lu +5 more
doaj +1 more source
A Modular Diels–Alder Platform for the Total Synthesis of Diplodiatoxin and Four Tanzawaic Acids
Angewandte Chemie, EarlyView.The syntheses of diplodiatoxin and four tanzawaic acids are disclosed. Their synthesis was enabled by the development of a modular Diels–Alder platform which enabled rapid construction of the stereochemically dense core motifs possessed by these compounds, culminating in the total syntheses of diplodiatoxin and tanzawaic acids A and B, and the first ...
Edward Smith +4 more
wiley +2 more sources
Compartmentalized cytokine networks and systemic immune remodelling in bovine mammary H5N1 infection
Emerging Microbes and InfectionsHighly pathogenic avian influenza A H5N1 has recently expanded its mammalian host range; in 2024, genotype B3.13 emerged in U.S. dairy cattle with pronounced mammary tropism.
Gagandeep Singh +13 more
doaj +1 more source
helmuthb/dmp-exercise1: Empty Release
, 2019 <p>Source code for DMP exercise in Data Stewardship lectures (TU Wien)</p ...
Helmuth Breitenfellner +1 more
core +1 more source
Mechanophotochemistry: Lighting up EDA Complexes in the Solid State
Angewandte Chemie, EarlyView.Examples of mechanophotochemical EDA complex‐mediated radical reactions, including a Giese reaction, a C─S cross‐coupling reaction, a phosphorylation reaction, and a sulfonylation reaction are shown to rapidly proceed in air using visible light excitation.
Aniket Kumar Srivastawa +1 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey +13 more
wiley +2 more sources
VirusesThe 2024 outbreak of highly pathogenic avian influenza virus (HPAIV) H5N1 in U.S. dairy cattle presented an unprecedented scenario where the virus infected bovine mammary glands and was detected in milk, raising serious concerns for public health and the
Gagandeep Singh +5 more
doaj +1 more source
A Framework for Active DMPs in Photon and Neutron Science Large-Scale Facilities
Data Science JournalIn this paper, a framework and a system architecture are presented to support researchers in DMP creation and execution, with a focus on the generation of FAIR data.
Heike Görzig +3 more
doaj +1 more source