Results 41 to 50 of about 33,896 (240)

Heteroleptic Ag(I) Complexes Bearing Benzothiazole and Benzoxazole Ligands for Orange‐Red Light‐Emitting Electrochemical Cells

Advanced Optical Materials, EarlyView.
Light‐emitting Electrochemical Cells (LECs) are appealing electroluminescent devices with potential application in low‐cost, large‐area display technology and disposable devices. In the manuscript, a novel family of bright photo‐ and electro‐active heteroleptic silver(I) is presented and comprehensively investigated.
Valerio Giuso, Jing‐Yuan Zhuang, Christophe Gourlaouen, Cristina Cebrián, Hai‐Ching Su, Matteo Mauro   +5 more
wiley   +1 more source

Accelerating Phosphate Transport Across Membranes via Synergistic Chemical‐Electrochemical Carriers

Angewandte Chemie, EarlyView.
A new membrane design principle based on synergistic chemical and electrochemical carriers is proposed to construct an electro‐driven carrier‐conducting membrane for high‐throughput phosphate transport. Monodispersed ferrihydrite nanoparticles embedded within the membrane act as built‐in phosphate carriers, enabling accelerated phosphate migration via ...
Lei Xia, Yangbo Qiu, Qingzhi Liu, Mengjiao Guan, Xi Zhang, Raf Dewil, Jin Shang, Yan Zhao, Bart Van der Bruggen, Chuyang Tang   +9 more
wiley   +2 more sources

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Single‐Atom‐Enhanced Fully Inkjet‐Printed Electrochemical Sensor for Dopamine Detection

Advanced Science, EarlyView.
Fully inkjet‐printed paper‐based dopamine sensors are fabricated using nitrogen‐doped graphene acid functionalized with copper single atoms. The copper sites uniquely enhance dopamine oxidation through strong molecular adsorption, as verified by electrochemical measurements and DFT calculations. The approach highlights the potential of single‐atom inks
Martin‐Alex Nalepa, David Panáček, Vítězslav Hrubý, Matěj Jendrišák, Rostislav Langer, Michal Langer, Petr Jakubec, Ivan Dědek, Vojtěch Kupka, Michal Mazur, Radek Zbořil, Michal Otyepka   +11 more
wiley   +1 more source

New risk factors for post-surgical recurrent diabetic maculopathy in type 2 diabetes mellitus

Journal of Ophthalmology, 2019
Background: Some pathogenetic risk factors (platelet-derived growth factor (PDGF); tumor necrosis factor alpha (TNF?); and Endothelin-1 (ET1)) are involved in the development of diabetic maculopathy (DMP) in type 2 diabetes mellitus. We hypothesized that
S.Yu. Mogilevskyy, Iu.O. Panchenko, S.V. Ziablitsev   +2 more
doaj   +1 more source

Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, EarlyView.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +2 more sources

Road to a Chemistry-Specific Data Management Plan

Data Science Journal
In order to develop a discipline-specific data management plan (DMP) template, it is important to obtain information from researchers. For a chemistry-specific template, NFDI4Chem conducted a series of interviews with 27 participants and used data from ...
Ann-Christin Andres, Daniela Adele Hausen, Jochen Ortmeyer, Sonja Herres-Pawlis   +3 more
doaj   +1 more source

Impacts of Dimethyl Phthalate on the Bacterial Community and Functions in Black Soils

Frontiers in Microbiology, 2015
Dimethyl phthalate (DMP), also known as endocrine disruptor and one of the phthalate esters (PAEs), is ubiquitous environmental pollutant, and the impacts on human health arouse great concerns.
Zhigang eWang
doaj   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source