Results 151 to 160 of about 29,043 (297)

Systematic Review of the Huntington's Disease Drug Development Pipeline, 2014 to 2025

Movement Disorders, EarlyView.
Abstract Background In the past decade, significant advances have improved our understanding of the mechanisms underlying HD pathobiology leading to several putative therapeutic targets for HD. Objective The aim was to describe the Huntington's disease (HD) drug development clinical pipeline.
Pavlina Konstantinova, Jenny Townhill, Juliana Bronzova, Viktoria Andreeva, Swati Sathe, Cristina Sampaio   +5 more
wiley   +1 more source

Short- and Long-Acting Psychedelics: Structure-Activity Relationships, Pharmacology, and Implications for Neuropsychiatric Therapeutics. [PDF]

ACS Chem Neurosci
Bhat A, Zolali E, Sakib MA, Rahimian M, McMahon LR, German N, Obeng S.   +6 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Overcoming Pharmacokinetic and Peripheral Safety Challenges in Psychedelic Therapies: The Promise of Advanced Drug Delivery Systems. [PDF]

ACS Pharmacol Transl Sci
Zhang T, Lin C, Wang X.
europepmc   +1 more source

An Improved Air Film Model for Studying the Tilt Characteristics of Aerostatic Thrust Bearings

International Journal of Mechanical System Dynamics, EarlyView.
ABSTRACT In this study, an improved mass‐spring model that treats the lubricating air film as distributed springs is proposed to calculate the static and dynamic angular stiffness of aerostatic thrust bearings. The proposed model refines the traditional mass‐spring model by introducing the spatially varying mechanical properties of the air film and the
Hui Zhuang, Jianguo Ding, Yu Chang
wiley   +1 more source

Serum Uric Acid Trajectories in Multiple Sclerosis: A 5-Year Longitudinal Comparison of High- and Moderate-Efficacy Therapies. [PDF]

Med Sci (Basel)
Cucu LE, Săcărescu A, Oancea A, Ignat BE, Grosu C, Baciu LC, Chirica C, Popescu G, Maștaleru A, Leon MM.   +9 more
europepmc   +1 more source

Urodynamic Voiding Patterns in Multiple Sclerosis

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims This study aimed to describe urodynamic voiding patterns in patients with MS (PwMS) using standardized assessments, and to compare the performance of the available nomograms and indices for obstruction and bladder contractility. Methods PwMS and lower urinary tract symptoms underwent cystometry and pressure flow studies.
Camille Chesnel, Nicolas Turmel, Maelys Teng, Emilie Blouet, Gérard Amarenco, Claire Hentzen   +5 more
wiley   +1 more source

N,N-Dimethyltryptamine (DMT) Acutely Exposed to Mouse Ventral Tegmental Area I_h-Negative Neurons Alters the Firing Rate and Conductance in a Sex-Dependent Manner. [PDF]

J Neurochem
Eliasen JN, Rezagholizadeh A, Jacobsen HP, Kohlmeier KA.   +3 more
europepmc   +1 more source

Real‐World Safety and Effectiveness of Glatiramer Acetate in Patients With Multiple Sclerosis: Final Results of Post‐Marketing Surveillance in Japan

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Background Glatiramer acetate is an injectable disease‐modifying therapy indicated for multiple sclerosis (MS). Aim To evaluate the real‐world safety and effectiveness of glatiramer acetate for MS in Japan. Methods A prospective, multicenter, observational, all‐case post‐marketing survey was conducted in Japan between November 2015 and March ...
Masaaki Niino, Eriko Hayashi, Mai Itani, Jun‐ichi Kira   +3 more
wiley   +1 more source

Same pattern, different result: Algorithmic inconsistency in breath alcohol testing-case reports. [PDF]

Forensic Sci Int Synerg
Olson A, Ramsay C.
europepmc   +1 more source