Results 171 to 180 of about 87,328 (317)

A short-acting psychedelic intervention for major depressive disorder: a phase IIa randomized placebo-controlled trial. [PDF]

Nat Med
Erritzoe D, Barba T, Benway T, Joel Z, Good M, Layzell M, Jones MB, Campbell G, Murphy-Beiner A, Rands P, Boyce M, Topping H, Weiss B, Timmermann C, Nutt D, Carhart-Harris R, Routledge C, James E.   +17 more
europepmc   +1 more source

Exploring the Fragmentation of Sodiated Species Involving Covalent‐Bond Cleavages for Metabolite Characterization

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Electrospray (ESI), the most popular desorption/ionization technique used in mass spectrometry‐based metabolomics, generates both protonated and deprotonated molecules, as well as adduct ions, sodium being the most frequent monoatomic cation entering their composition.
Annelaure Damont, Ekaterina Darii, Chenqin Cao, Anaïs Legrand, Alain Perret, Sylvain Dechaumet, Amina S. Woods, Christophe Junot, Jean‐Claude Tabet, François Fenaille   +9 more
wiley   +1 more source

Toxicometabolomics Characterization of Two N1-Sulfonated Dimethyltryptamine Derivatives in Zebrafish Larvae and Human Liver S9 Fractions Using Liquid Chromatography-High-Resolution Mass Spectrometry. [PDF]

Metabolites
Punnamraju P, Manier SK, Hemmer S, Grill M, Schippers P, Herrmann J, Meyer MR.   +6 more
europepmc   +1 more source

5‐Methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden, Michael Kelleher, Fiona Dunbar, Anna O. Ermakova, Luke Mitcheson, Claire Roberts, James J. Rucker, Gemma Scott, Ivan Saeger, Francesca Small, Mathieu Seynaeve   +10 more
wiley   +1 more source

Combined Neuroprotective Effects of N,N-Dimethyltryptamine and Ventral Root Reimplantation Following Spinal Root Avulsion in Rats. [PDF]

J Neurochem
Aponte PAC, Montoya EH, Mazali IO, Sussulini A, Barraviera B, Ferreira RS, Cartarozzi LP, de Oliveira ALR.   +7 more
europepmc   +1 more source

Changes over time in hallucinogen‐related emergency department visits in Ontario, Canada

Addiction, EarlyView.
Abstract Background and aims Recent increasing interest in hallucinogens has underscored the critical gaps in our understanding of their adverse health effects and healthcare usage over time. The current study aimed to examine changes in emergency department (ED) visit rates involving hallucinogens, clinical outcomes of visits and the characteristics ...
Daniel T. Myran, Rachael MacDonald‐Spracklin, Alexander R. Levesque, Michael Pugliese, Jess G. Fiedorowicz, André J. McDonald, Joshua D. Rosenblat, Ian Colman, Josephine Zein, Marco Solmi   +9 more
wiley   +1 more source

Single-dose DMT reverses anhedonia and cognitive deficits via restoration of neurogenesis in a stress-induced depression model. [PDF]

Transl Psychiatry
Lima da Cruz RV, Costa RBGM, de Queiroz GM, Stojanovic T, Moulin TC, Leão RN.   +5 more
europepmc   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Safety pharmacology of acute mescaline administration in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims Psychedelics, including mescaline, may serve as novel treatments for depression and anxiety. However, data is scarce on the safety of mescaline. Methods The present pooled analysis included two double‐blind, randomized, placebo‐controlled studies with a total of 48 participants and 96 mescaline administrations. Single oral‐dose administrations (n =
Aaron Klaiber, Mélusine Humbert‐Droz, Laura Ley, Yasmin Schmid, Matthias E. Liechti   +4 more
wiley   +1 more source

Estimating the Future Health and Social Care Costs of Alzheimer's Disease Dementia in the UK: Impact of Disease Modifying Therapy Efficacy, Uptake, and Care Model - A Scenario Modelling Study. [PDF]

Int J Geriatr Psychiatry
Evans M, Ritchie C, Trepel D, Hahn-Pedersen JH, Kettle J, Chan MS, Bray BD, Clark A, Ivkovic M, Wichmann CA, Edwards S.   +10 more
europepmc   +1 more source