Results 191 to 200 of about 32,964 (245)

Water‐Dispersible Ruthenium Nanocatalyst for Carbonyl Reduction With D2 or T2 in Aqueous Media

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
We report the synthesis and characterization of water‐dispersible ruthenium nanoparticles that catalyze the reductive deuteration and tritiation of carbonyl compounds in aqueous media, enabling efficient access to a broad range of isotopically labeled polar molecules, including cyclic peptides, antibody‐drug conjugate linkers, pegylated derivatives ...
Elisa Martinelli, Rafael Jiménez Rioboo, Remo Weck, Sophie Feuillastre, Luis M. Martínez‐Prieto, Grégory Pieters, Volker Derdau   +6 more
wiley   +2 more sources

Effectiveness of escalation versus early high-efficacy therapies on progression independent of relapse activity in multiple sclerosis: a Danish nationwide study. [PDF]

BMJ Neurol Open
Varju E, Pontieri L, Mahler MR, Magyari M, DMSG Study Group.   +4 more
europepmc   +1 more source

Diagnosing Dementias: Many Names, Many Faces

Journal of the American Geriatrics Society, EarlyView.
Michael Tran Duong
wiley   +1 more source

Identification of Sodium/Myo‐Inositol Transporter 1 as a Major Determinant of Arterial Contractility

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
The tonicity‐responsive enhancer binding‐protein (TonEBP) and serum glucocorticoid kinase (SGK) sense a rise in extracellular hypertonicity resulting in an increase SMIT1 membrane abundance in vascular smooth muscle cells. SMIT1 associates with Kv7.4/5, Gβγ, and KCNE4, promoting hyperpolarization, reduced voltage‐gated calcium channel (VGCC) opening ...
Elizabeth A. Forrester, Skye Lau, Miguel Benitez‐Angeles, Christopher J. Garland, Vincenzo Barrese, Anthony P. Albert, Iain A. Greenwood   +6 more
wiley   +1 more source

Real-world Roche Elecsys^® and Fujirebio Lumipulse^® inter-platform comparability and clinical validation of plasma neurofilament light chain in multiple sclerosis. [PDF]

J Neurol
Criscuolo V, Nicolella V, Polito C, Sirica R, Fiorenza M, Sorvillo D, Cave ID, Carotenuto A, Petracca M, Lanzillo R, Castaldo G, Morra VB, Terracciano D, Moccia M.   +13 more
europepmc   +1 more source

Peptidthioester und Peptidtriazolderivate durch Duale Modifikation von Peptidthiosulfonaten auf dem Harz

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
Es wird eine Strategie zur dualen Modifikation von Peptiden auf der Festphase vorgestellt, die die S‐Alkinylierung von Peptidthiosulfonaten und eine regioselektive, iridiumkatalysierte Azid‐Thioalkin‐Zykloaddition umfasst. Dieses Verfahren ermöglicht zuverlässig den Zugang zu Peptiden mit komplexen, nicht‐kanonischen Modifikationen und ist mit ...
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas   +5 more
wiley   +1 more source

A systematic review of the pharmacokinetics of classical serotonergic psychedelic compounds in healthy adult subjects. [PDF]

J Psychopharmacol
Hampsey E, Martin K, Kalfas M, Benson L, Wihlborg S, Jelen L, Young AH, Rucker J.   +7 more
europepmc   +1 more source

Effect of ocrelizumab on rates of retinal atrophy in relapsing multiple sclerosis. [PDF]

Mult Scler J Exp Transl Clin
McCormack B, Bacchetti A, Lin TY, Moretti GS, Filippatou A, Gakis G, O'Donnell MM, Lambert CM, Lee NJ, Ecoff K, Davis S, Otero-Duran G, Gulati A, Didouchevski A, Lievers E, Pellegrini N, Ezzedin O, Lambe J, Moussa H, Fitzgerald K, Newsome SD, Mowry EM, Sotirchos ES, Calabresi PA, Nourbakhsh B, Saidha S.   +25 more
europepmc   +1 more source

Peptide Thioester and Triazole Derivatives Through On‐Resin Dual‐Modification of Peptide Thiosulfonates

Angewandte Chemie International Edition, Volume 65, Issue 38, 14 September 2026.
An on‐resin dual‐modification strategy for peptides is presented, comprising S‐alkynylation of peptide thiosulfonates and regioselective iridium‐catalyzed azide–thioalkyne cycloaddition. This method reliably provides access to peptides with intricate non‐canonical modifications, being compatible with complex peptides, alkynes and azides.
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas   +5 more
wiley   +1 more source

Monitoring the Electrical Phenotype of Transthyretin Amyloid Cardiomyopathy in the Era of Disease-Modifying Therapy. [PDF]

Circ Rep
Yonezu K, Kondo H, Takahashi N.
europepmc   +1 more source