Results 191 to 200 of about 28,987 (300)

Disease outcomes with ublituximab in treatment-naïve participants: subpopulation analyses of the phase 3 ULTIMATE I and II studies in participants with relapsing multiple sclerosis. [PDF]

Front Immunol
Robertson D, Alvarez E, Steinman L, Hartung HP, Qian P, Selmaj K, Wray S, Wynn D, Fox EJ, Mok K, Miskin HP, Xu Y, Garner CA, Cree BAC.   +13 more
europepmc   +1 more source

Exploring the Fragmentation of Sodiated Species Involving Covalent‐Bond Cleavages for Metabolite Characterization

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Electrospray (ESI), the most popular desorption/ionization technique used in mass spectrometry‐based metabolomics, generates both protonated and deprotonated molecules, as well as adduct ions, sodium being the most frequent monoatomic cation entering their composition.
Annelaure Damont, Ekaterina Darii, Chenqin Cao, Anaïs Legrand, Alain Perret, Sylvain Dechaumet, Amina S. Woods, Christophe Junot, Jean‐Claude Tabet, François Fenaille   +9 more
wiley   +1 more source

Reframing dementia care in the era of disease-modifying therapies: informational, psychosocial, and systemic insights from Japan. [PDF]

BMC Health Serv Res
Ito K, Tsuda S, Wake T, Hatakeyama A, Ogisawa F, Ono M, Nakayama R, Wakui T, Nagano N, Iwata A.   +9 more
europepmc   +1 more source

5‐Methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden, Michael Kelleher, Fiona Dunbar, Anna O. Ermakova, Luke Mitcheson, Claire Roberts, James J. Rucker, Gemma Scott, Ivan Saeger, Francesca Small, Mathieu Seynaeve   +10 more
wiley   +1 more source

Predicting disease progression in multiple sclerosis with clinically accessible information and technology. [PDF]

J Neurol
Fuchs TAN, Schoonheim MM, Strijbis EMM, Jelgerhuis JR, Horakova D, Havrdova EK, Uher T, Zivadinov R, Ozakbas S, Girard M, Alroughani R, Grammond P, Lugaresi A, Tomassini V, Kalincik T, Roos I, Gerlach O, van der Walt A, Khoury SJ, van Pesch V, Surcinelli A, Foschi M, Sa MJ, D'amico E, Kuhle J, Cartechini E, Maimone D, Karabudak R, Soysal A, Spitaleri D, Laureys G, Taylor B, D'hooghe M, Ampapa R, Castillo-Triviño T, Altintas A, Gray O, Gouider R, Meca-Lallana JE, Kermode AG, Fabis-Pedrini M, Carroll WM, de Gans K, Sanchez-Menoyo JL, Etemadifar M, Al-Asmi A, McCombe P, Simu M, Yetkin MF, Al-Harbi T, Csepany T, Lalive P, Hardy TA, Ramanathan S, Willekens B, Sempere AP, Cárdenas-Robledo S, Habek M, Singhal B, Grigoriadis N, Simo M, Shaygannejad V, Blanco Y, Aguera-Morales E, Garber J, Solaro C, Shuey N, Khurana D, Decoo D, Moghadasi AN, Buzzard K, Skibina O, John N, Petersen T, Weinstock-Guttman B.   +74 more
europepmc   +1 more source

Craving and personal functioning as mediators of extended‐release buprenorphine efficacy: A four‐way decomposition analysis from a randomised trial

Addiction, EarlyView.
Abstract Aims To investigate whether the treatment effect of extended‐release buprenorphine (BUP‐XR) on opioid‐free days in opioid use disorder (OUD) is mediated by reductions in opioid craving and improvements in personal functioning. Design and setting Exploratory causal mediation analysis using VanderWeele's four‐way decomposition framework in a 24 ...
John Marsden, Mike Kelleher, Fiona Cowden, Edward Day, Jonathan Dewhurst, Rachel Evans, Eilish Gilvarry, Natalie Lowry, Luke Mitcheson, Robert Murray, Sophie Quarshie, Zoë Hoare   +11 more
wiley   +1 more source

Comparative Effectiveness and Safety of Rituximab Versus Ocrelizumab in Relapsing-Remitting Multiple Sclerosis: A Finnish Population-Based Matched Cohort Study. [PDF]

Eur J Neurol
Savolainen M, Soilu-Hänninen M, Nurmi H, Viitala M, Tienari P, Atula S, Laakso SM.   +6 more
europepmc   +1 more source

Longitudinal Follow‐Up of Gut and Salivary Microbiota in Children With Food Protein‐Induced Enterocolitis Syndrome

Allergy, EarlyView.
This study aimed to compare both the gut and salivary microbiota over time between allergic and tolerant patients and matched controls. Allergic patients with food protein‐induced enterocolitis syndrome exhibited lower gut and salivary alpha‐diversities, several genus‐level differences, and higher acetate levels than controls.
Anais Lemoine, Karine Adel‐Patient, Nathalie Kapel, Camille Mayeur, Marie‐Noelle Rossignol, Aurelia Bruneau, Patrick Tounian, Muriel Thomas, Ioannis Nicolis   +8 more
wiley   +1 more source

Long-term disability after initiation of platform versus high-efficacy disease-modifying therapy in relapsing-onset multiple sclerosis. [PDF]

J Neurol
Guo J, Olsson T, Johansson E, Alfredsson L, Hedström AK.   +4 more
europepmc   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source