Results 241 to 250 of about 87,328 (317)

Neutron Crystallography Study of Host–Pathogen Recognition Enhanced by Hydrogen/Deuterium Exchange on Carbohydrates

ChemistryEurope, Volume 4, Issue 3, March 2026.
Neutron macromolecular crystallography enabled by deuteration of biomolecules reveals how the opportunistic pathogen Pseudomonas aeruginosa utilizes calcium‐dependent lectin for binding to human sugars. Neutron diffraction on the complex highlights hydrogen bond network, protonation of amino acids and role of calcium ion.
Theodore Arnaud, Chloé Tatol, Juliette M. Devos, Lukas Gajdos, Sébastien Vidal, Marek Korsak, Annabelle Varrot, Michaela Wimmerova, Sophie Feuillastre, Matthew P. Blakeley, Anne Imberty   +10 more
wiley   +1 more source

Diagnoses of Multiple Sclerosis and Related Disorders and Disease-Modifying Therapies: A Comparison of the Danish Multiple Sclerosis Registry With Other Danish Health Registries. [PDF]

Brain Behav
Joensen H, Framke E, Pontieri L, Magyari M.   +3 more
europepmc   +1 more source

Double‐Filtration Plasmapheresis Versus Efgartigimod for Generalized Myasthenia Gravis: Severity‐Stratified Benefits in a Prospective Observational Multicenter Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Both Double‐Filtration Plasmapheresis (DFPP) and efgartigimod effectively treat acute exacerbations of generalized myasthenia gravis (gMG), with efficacy rising across successive sessions. In moderate‐to‐severe gMG, 3/5‐session DFPP outperformed 4‐infusion efgartigimod, while efficacy was comparable in mild cases.
Kan Wang, Hanyu Xin, Mengze Zhang, Qiuju Li, Yanan Wu, Xia Li, Jing Peng, Chong Xie, Xiajun Zhou, Li Gao, Xuzhong Pei, Yiwei Yang, Yuhui Wang, Yuan Zhong, Lu Zhang, Desheng Zhu, Yangtai Guan   +16 more
wiley   +1 more source

Disability progression in multiple sclerosis: a latent class analysis of predictors. [PDF]

J Neurol
Guo J, Olsson T, Alfredsson L, Hedström AK.   +3 more
europepmc   +1 more source

Pharmacokinetic Comparison Between a Fixed‐Dose Combination of Atorvastatin/Fenofibrate 20/145 mg and the Corresponding Individual Components

Clinical Pharmacology in Drug Development, Volume 15, Issue 3, March 2026.
Abstract Co‐administration of atorvastatin and fenofibrate has demonstrated clinical benefits in patients with dyslipidemia. To improve convenience and adherence, a fixed‐dose combination (FDC) of the two agents has gained interest. This study aimed to compare the pharmacokinetics (PKs) and safety of an FDC of atorvastatin/fenofibrate 20/145 mg with ...
Seungri Lee, Juyoung Khwarg, Sungyeun Bae, Dong‐Min Park, Heejung Park, SeungHwan Lee, Kyung‐Sang Yu   +6 more
wiley   +1 more source

Developments and challenges in hit progression within fragment-based drug discovery. [PDF]

Nat Commun
Grosjean H, Biggin PC.
europepmc   +1 more source

Digital Twin Integration in Project Life Cycle Management—A Review

Engineering Reports, Volume 8, Issue 3, March 2026.
This study explores the integration of digital twin (DT) technology within project life cycle management (PLM), focusing on its transformative impact on industries like aerospace, automotive, healthcare, and construction. By creating real‐time virtual models synchronized with physical assets, DTs enable predictive maintenance, operational optimization,
Md. Injamamul Haque Protyai, Rajowone Shariar, Hrittik Mural   +2 more
wiley   +1 more source

Pharmacodynamic effects and plasma pharmacokinetics of N, N-dimethyltryptamine after intranasal versus subcutaneous administration in male rats. [PDF]

Psychopharmacology (Berl)
Baumann MH, Glatfelter GC, Walton SE, Krotulski AJ, Witowski CG, von Salm JL.   +5 more
europepmc   +1 more source

Time‐Varying Brain Functional Reconfiguration Patterns Associated With Fatigue in Multiple Sclerosis

Human Brain Mapping, Volume 47, Issue 4, March 2026.
Fatigue in people with multiple sclerosis has been associated with more unstable and dispersed patterns of brain network reconfiguration, particularly within the limbic network. These findings suggest that inefficient and energetically demanding time‐varying communication among brain regions may contribute to the subjective experience of fatigue ...
Stefanie Hechenberger, Tommy A. A. Broeders, Marloes D. A. Bet, Birgit Helmlinger, Christian Tinauer, Stefan Ropele, Bettina Heschl, Sebastian Wurth, Anna Damulina, Michael Khalil, Menno M. Schoonheim, Christian Enzinger, Daniela Pinter   +12 more
wiley   +1 more source

Real-world experience with cladribine tablets in people with multiple sclerosis: effectiveness data from a multicenter Italian study. [PDF]

Ther Adv Neurol Disord
Lucchini M, Borriello G, Haggiag S, Nicoletti CG, Fantozzi R, Buscarinu MC, Ferrazzano G, Cortese A, Marinelli F, Monteleone F, Centonze D, Conte A, Ferraro E, Gasperini C, Marfia GA, Pozzilli C, Salvetti M, Barbuti E, Bellucci G, Bianco A, Carlomagno V, Cruciani A, De Giglio L, Dionisi C, Ianniello A, Malimpensa L, Nasello M, Nociti V, Prosperini L, Tortorella C, Mirabella M.   +30 more
europepmc   +1 more source