Results 91 to 100 of about 854,281 (317)

Systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops [PDF]

, 2005
Background Public databases now contain multitude of complete bacterial genomes, including several genomes of the same species. The available data offers new opportunities to address questions about bacterial genome evolution, a task that requires ...
Petit M-A, El Karoui, Meriem, El Karoui, M, Bourgait, Isabelle, Gendrault-Jacquemard, A, Sourivong, Frédéric, Gendrault, Annie, Gendrault-Jacquemard, Gendrault-Jacquemard A, Chiapello H, Chiapello, H, Sourivong F, Bourgait I, Heuclin G, El Karoui M, El Karoui, Meriem, M., Heuclin, G, Petit, M-A, Bourgait, I, Heuclin, Gaëlle, Chiapello, Helene, Petit, Marie Agnès, Petit, Marie Agnes, M. A., Sourivong, F, Gendrault, Annie   +23 more
core   +1 more source

DNA origami-enhanced binding of aptamers to Staphylococcus aureus cells

Biosensors and Bioelectronics: X
The combination of DNA origami nanostructures and aptamers provides a powerful technology for diagnostic assays. Here, we functionalized a DNA origami nanostructure with a Protein-A binding aptamer to target Staphylococcus aureus bacterial cells.
Yasaman Ahmadi, Trishant R. Umrekar, Natalie Mutter, Morgan Beeby, Ivan Barišić   +4 more
doaj   +1 more source

Narrative Review of Bacterial DNA Extraction: Key Points and Challenges [PDF]

SINAI International Scientific Journal
Extraction of bacterial DNA is a critical step in obtaining high-quality DNA. The overall quality, yield, and integrity of the genomic DNA isolated affects the success of any downstream applications.
Samar Solyman, Manar El Samak
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Orf protein modulates phage and bacterial pathways of genetic recombination [PDF]

, 2008
The emergence of novel pathogenic organisms due to the acquisition of virulencedeterminants from bacteriophages has generated significant interest in the pathways responsible for genomic rearrangements.
Bowers, Laura Yvonne
core  

Functional Characterization of Excision Repair and RecA-Dependent Recombinational DNA Repair in Campylobacter jejuni

, 2009
The presence and functionality of DNA repair mechanisms in Campylobacter jejuni are largely unknown. In silico analysis of the complete translated genome of C.
Dep Infectieziekten Immunologie, de Boer, A.G., Graaf-van Bloois, L., van der, Gaasbeek, E.J., Strategic Infection Biology, van Putten, J.P.M., van der Graaf-van Bloois, L., Boer, P., Wagenaar, J.A., Vermaning, B.J., van der Wal, F.J., Wal, F.J., van der, Putten, J.P.M., van, Boer, A.G., de   +13 more
core   +1 more source

Expression in mammalian cells of a cloned gene encoding murine DNA methyltransferase [PDF]

, 1991
Mammalian DNA cytosine-5-methyltransferase (MTase, EC 2.1.1.37) is an essential component for establishing and maintaining cell-type specific methylation patterns in the genome. The cDNAfor the murine enzyme was previously cloned in segments.
Häuselmann, Remo, Bestor, Timothy H., Bestor, T. H., Page, A. W., Page, Andrea W., Hergersberg, M., Leonhardt, Heinrich, Häuselmann, R., Czank, A., Czank, Andreas, Schaffner, Walter, Schaffner, W., Hergersberg, Martin, Leonhardt, H.   +13 more
core   +1 more source

DnaG Primase—A Target for the Development of Novel Antibacterial Agents

Antibiotics, 2018
The bacterial primase—an essential component in the replisome—is a promising but underexploited target for novel antibiotic drugs. Bacterial primases have a markedly different structure than the human primase.
Stefan Ilic, Shira Cohen, Meenakshi Singh, Benjamin Tam, Adi Dayan, Barak Akabayov   +5 more
doaj   +1 more source

Blood Metagenome in Health and Psoriasis

Frontiers in Medicine, 2020
A survey and analytical assessment of the results of fundamental works on studying blood metagenome (set of all non-human DNA) is carried out. All works on determining bacterial DNA concentration in the whole blood of healthy people are reviewed ...
Nikolay Korotky, Mikhail Peslyak, Mikhail Peslyak   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source