Results 1 to 10 of about 762,695 (253)

Rapid and Sensitive Detection of Severe Acute Respiratory Syndrome Coronavirus 2 in Label-Free Manner Using Micromechanical Sensors

open access: yesSensors, 2021
Coronavirus (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been identified as a deadly pandemic. The genomic analysis of SARS-CoV-2 is performed using a reverse transcription-polymerase chain reaction (RT-PCR)
Dalal A. Aloraini   +4 more
doaj   +1 more source

Synthesis and Evaluation of MGB Polyamide-Oligonucleotide Conjugates as Gene Expression Control Compounds

open access: yesJournal of Nucleic Acids, 2023
MGB polyamide-oligonucleotide conjugates ON 1-4 with linked MGB polyamides at the 2-exocyclic amino group of a guanine base using aminoalkyl linkers were synthesized and evaluated in terms of binding affinity for complementary DNA containing the MGB ...
Kazuo Kamaike   +13 more
doaj   +1 more source

A Brief Review of Graphene-Based Biosensors Developed for Rapid Detection of COVID-19 Biomarkers

open access: yesBiosensors, 2023
The prevalence of mutated species of COVID-19 antigens has provided a strong impetus for identifying a cost-effective, rapid and facile strategy for identifying the viral loads in public places.
Narendhar Chandrasekar   +7 more
doaj   +1 more source

Design strategy of antidote sequence for bivalent aptamer: Rapid neutralization of high‐anticoagulant thrombin‐binding bivalent DNA aptamer‐linked M08 with HD22

open access: yesResearch and Practice in Thrombosis and Haemostasis, 2021
Background Bivalent thrombin‐binding aptamers (TBAs) have great potential for the treatment of thrombosis because they exhibit high anticoagulant activity, and their complementary single‐stranded DNA (ssDNA) sequences work as an antidote.
Toru Yoshitomi   +3 more
doaj   +1 more source

Self-assembled endogenous DNA nanoparticles for auto-release and expression of the eGFP gene in Bacillus subtilis

open access: yesCommunications Biology, 2022
The DNA origami design algorithm DAEDALUS is modified to design a nanoscale cube with a two-step assembly protocol, assembling 9 modules from three DNA scaffolds and the complementary staples, combined to form the DNA origami cube.
Linfeng Cao   +8 more
doaj   +1 more source

Towards New Liquid Crystal Phases of DNA mesogens [PDF]

open access: yesAPL Mater. 1 June 2023; 11 (6): 061129, 2023
Short, partially complementary, single-stranded (ss)DNA strands can form nanostructures with a wide variety of shapes and mechanical properties. It is well known that semiflexible, linear dsDNA can undergo an isotropic to nematic (IN) phase transition and that sufficiently bent structures can form a biaxial nematic phase.
arxiv   +1 more source

Novel codons in rat Pdx-1 complementary DNA

open access: yesBMC Research Notes, 2018
Objectives Pancreatic and duodenal homeobox-1 (Pdx-1) is a homeodomain-containing transcription factor essential for pancreatic development, beta-cell differentiation and the maintenance of mature beta cell function.
Takayoshi Kiba
doaj   +1 more source

Titanium Dioxide Nanoparticle-Based Interdigitated Electrodes: A Novel Current to Voltage DNA Biosensor Recognizes E. coli O157:H7. [PDF]

open access: yesPLoS ONE, 2015
Nanoparticle-mediated bio-sensing promoted the development of novel sensors in the front of medical diagnosis. In the present study, we have generated and examined the potential of titanium dioxide (TiO2) crystalline nanoparticles with aluminium ...
Sh Nadzirah   +4 more
doaj   +1 more source

Melting Transition of Directly-Linked Gold Nanoparticle DNA Assembly [PDF]

open access: yesPhysica A, 350 (2005) 89-94, 2005
DNA melting and hybridization is a fundamental biological process as well as a crucial step in many modern biotechnology applications. DNA confined on surfaces exhibits different behavior from that in free solutions. The system of DNA-capped gold nanoparticles exhibits unique phase transitions and represents a new class of complex fluids.
arxiv   +1 more source

The Enhanced Sensitivity of a Porous Silicon Microcavity Biosensor Based on an Angular Spectrum Using CdSe/ZnS Quantum Dots

open access: yesSensors, 2019
To improve the detection sensitivity of porous silicon microcavity biosensors, CdSe/ZnS quantum dots are used to label complementary DNA molecules for the refractive index amplification and angular spectrum method for detection.
Rui Zhou   +3 more
doaj   +1 more source

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