Results 21 to 30 of about 762,695 (253)
Molecular Therapy: Nucleic Acids, 2013 A high mutation rate leading to tumor cell heterogeneity is a driver of malignancy in human cancers. Paradoxically, however, genomic instability can also render tumors vulnerable to therapeutic attack. Thus, targeting DNA repair may induce an intolerable
Mateusz Rytelewski +5 more
doaj +1 more source
Scientific Reports, 2023 The tetrameric tumor suppressor p53 represents a great challenge for 3D-structural analysis due to its high degree of intrinsic disorder (ca. 40%). We aim to shed light on the structural and functional roles of p53’s C-terminal region in full-length ...
Alessio Di Ianni +8 more
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Insights into DNA-mediated interparticle interactions from a coarse-grained model [PDF]
J. Chem. Phys. 141, 184901 (2014), 2015 DNA-functionalized particles have great potential for the design of complex self-assembled materials. The major hurdle in realizing crystal structures from DNA-functionalized particles is expected to be kinetic barriers that trap the system in metastable amorphous states.
arxiv +1 more source
Molecular Spiders in One Dimension [PDF]
, 2007 Molecular spiders are synthetic bio-molecular systems which have "legs" made of short single-stranded segments of DNA. Spiders move on a surface covered with single-stranded DNA segments complementary to legs.
Alberts B +21 more
core +4 more sources
HLA genotyping by next-generation sequencing of complementary DNA
BMC Genomics, 2017 Background Genotyping of the human leucocyte antigen (HLA) is indispensable for various medical treatments. However, unambiguous genotyping is technically challenging due to high polymorphism of the corresponding genomic region.
Hidenobu Segawa +2 more
doaj +1 more source
Theory on the mechanism of DNA renaturation: Stochastic nucleation and zipping [PDF]
, 2015 Renaturation of complementary single strands of DNA is one of the important processes that requires better understanding in the view of molecular biology and biological physics.
Murugan, Rajamanickam +1 more
core +4 more sources
F1000Research, 2014 Conventionally, in a polymerase chain reaction (PCR), oligonucleotide primers bind to the template DNA in an antiparallel complementary way and the template DNA is amplified as it is.
Vikash Bhardwaj, Kulbhushan Sharma
doaj +1 more source
Efficiency of peptide nucleic acid-directed PCR clamping and its application in the investigation of natural diets of the Japanese eel leptocephali. [PDF]
PLoS ONE, 2011 Polymerase chain reaction (PCR)-clamping using blocking primer and DNA-analogs, such as peptide nucleotide acid (PNA), may be used to selectively amplify target DNA for molecular diet analysis.
Takeshi Terahara +7 more
doaj +1 more source
Specificity, flexibility and valence of DNA bonds guide emulsion architecture [PDF]
Soft Matter, 2013,9, 9816-9823, 2013 The specificity and thermal reversibility of DNA interactions have enabled the self-assembly of crystal structures, self-replicating materials and colloidal molecules. Grafting DNA onto liquid interfaces of emulsions leads to exciting new architectural possibilities due to the mobility of the DNA ligands and the patches they form between bound droplets.
arxiv +1 more source
Roles of the Bloom's syndrome helicase in the maintenance of genome stability [PDF]
, 2005 The RecQ family of DNA helicases is highly conserved in evolution from bacteria to humans. Of the five known human RecQ family members, three (BLM, WRN and RECQ4, which cause Bloom's syndrome, Werner's syndrome and Rothmund-Thomson syndrome respectively)
Bachrati, Csanad +5 more
core +1 more source