Results 91 to 100 of about 1,505,314 (311)

In utero tobacco smoke exposure, DNA methylation, and asthma in Latino children. [PDF]

, 2019
BackgroundMaternal smoking during pregnancy is a risk factor for chronic disease later in life and has been associated with variability of DNA methylation at specific cytosine-phosphate-guanine (CpG) loci.
Barker, Beach, Beamer, Best, Cardenas, Chhabra, Cunningham, DiFranza, Galanter, Gibbs, Gilliland, Gilliland, Gilliland, Hanieh, Harb, Hu, Jaakkola, Jauniaux, Joubert, Joubert, Küpers, Lara, Morales, Oh, Perreira, Pickett, Rahmani, Reese, Reese, Rehan, Richiardi, Richmond, Richmond, Sharma, Shorey-Kendrick, Stick, Stocks, Tong, Upton, van der Laan, Vanderweele, VanderWeele, Waterland, Wongtrakool, Wu, Zeilinger, Zhang, Zhong   +47 more
core   +1 more source

Phylogenetic classification of short environmental DNA fragments [PDF]

Nucleic Acids Research, 2008
Metagenomics is providing striking insights into the ecology of microbial communities. The recently developed massively parallel 454 pyrosequencing technique gives the opportunity to rapidly obtain metagenomic sequences at a low cost and without cloning bias.
Krause, Lutz, Diaz, Naryttza N., Goesmann, Alexander, Kelley, Scott, Nattkemper, Tim Wilhelm, Rohwer, Forest, Edwards, Robert A., Stoye, Jens   +7 more
openaire   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Targeting Terrestrial Vertebrates With eDNA: Trends, Perspectives, and Considerations for Sampling

Environmental DNA
Terrestrial vertebrates are experiencing worldwide population declines and species extinctions. To effectively conserve remaining populations and species, rapid, cost‐effective, and scalable methods are needed to complement longstanding monitoring ...
Joshua P. Newton, Morten E. Allentoft, Philip W. Bateman, Mieke van derHeyde, Paul Nevill   +4 more
doaj   +1 more source

Prediction of Waste Generation Using Machine Learning: A Regional Study in Korea

Urban Science
Accurate forecasting of household waste generation is essential for sustainable urban planning and the development of data-driven environmental policies. Conventional statistical models, while simple and interpretable, often fail to capture the nonlinear
Jae-Sang Lee, Dong-Chul Shin
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Amazonian mammal monitoring using aquatic environmental DNA

Molecular Ecology Resources, 2020
AbstractEnvironmental DNA (eDNA) metabarcoding has emerged as one of the most efficient methods to assess aquatic species presence. While the method can in theory be used to investigate nonaquatic fauna, its development for inventorying semi‐aquatic and terrestrial fauna is still at an early stage.
Coutant, Opale, Richard‐hansen, Cécile, de Thoisy, Benoit, Decotte, Jean‐baptiste, Valentini, Alice, Dejean, Tony, Vigouroux, Régis, Murienne, Jérôme, Brosse, Sébastien   +8 more
openaire   +4 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Mangrove‐Associated Fish Biodiversity in Selected Philippine Bioregions During the Northeast (Amihan) Monsoon: Insights from eDNA Metabarcoding for Biomonitoring

Environmental DNA
Mangroves play a vital role in supporting diverse associated fauna, yet information on the fish communities they host in the Philippines remains limited.
Christian Jay R. Nob, Yukinobu Isowa, Jessah P. Trillo, Bernadeth Grace S. Pananganan, Earl Kevin T. Cooper, Allyn Duvin P. Hinoguin, Abner C. Evasco Jr., Jerpe E. Honghong Jr., Nonillon M. Aspe, Roger G. Dolorosa, Thesa R. Mendoza, Dixon T. Gevaña, Renan U. Bobiles, Joel Hassan G. Tolentino, Erwin Jones A. Tucong, Phresnofi D. Noval‐Don, Ruby C. Gonzales, Venus E. Leopardas, Tadashi Kajita   +18 more
doaj   +1 more source

Native Plasmid-Encoded Mercury Resistance Genes Are Functional and Demonstrate Natural Transformation in Environmental Bacterial Isolates. [PDF]

, 2019
Plasmid-mediated horizontal gene transfer (HGT) is a major driver of genetic diversity in bacteria. We experimentally validated the function of a putative mercury resistance operon present on an abundant 8-kbp native plasmid found in groundwater samples ...
Carlson, Hans K, Deutschbauer, Adam M, Kothari, Ankita, Mukhopadhyay, Aindrila, Soneja, Drishti, Tang, Albert   +5 more
core   +1 more source