Results 211 to 220 of about 171,193 (280)

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, Volume 13, Issue 8, 9 February 2026.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source

Genome-wide association for sarcoidosis identifies novel risk loci and genetic heritability in African and European ancestries: a meta-analysis from the Finngen, Million Veteran Program, UK Biobank, and Biobank Japan datasets. [PDF]

Orphanet J Rare Dis
Ricci A, Andolfi F, Sabbatini D, Gozzi F, Betto GD, Ventura P, Buzzetti E, Pietrangelo A, Clini E, Tonelli R, Andrisani D, de Guzman Marinduque BJ, Bergamini E, Vecchi C, Pegoraro E, Gregori D, Corradini E, Cerri S.   +17 more
europepmc   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

The GT1 domain of RNase J ensures RNA quality control through dsRNA binding in Arabidopsis plastids. [PDF]

Nucleic Acids Res
Baudry K, Skiada S, Burstein C, Liveanu V, Liehrmann A, Ceminsky M, Kleifeld O, Delannoy E, Launay-Avon A, Castandet B, Schuster G, Stern DB.   +11 more
europepmc   +1 more source

Autopolyploidization‐Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study demonstrates that monoploid, diploid, and autotetraploid Brassica rapa lines derived from the same genome exhibit distinct leaf morphology. Ploidy changes remodel chromatin accessibility and histone modifications to regulate gene expression, while key transcription factors BrGRF13 and BrARF11 control leaf size and polarity, driving ...
Haoyuan Dong, Yanhong Liu, Yuanming Liu, Shuxin Xuan, Huanhuan Chen, Lai Wei, Guibao Zhang, Hongcui Pei, Zilong Dai, Yanhua Wang, Jinzhu Qiao, Shuangxia Luo, Xueping Chen, Yiguo Hong, Jianjun Zhao, Shuxing Shen, Zefu Lu, Aixia Gu   +17 more
wiley   +1 more source

A next-generation dual guide CRISPR system for genetic interaction library screening. [PDF]

Nat Commun
Burgold T, Karakoc E, Gonçalves E, Barrio-Hernandez I, Dwane L, Silva R, Souster E, Sharma M, Beck A, Koh GCC, Zalmas LP, Garnett MJ, Bassett AR.   +12 more
europepmc   +1 more source

Structural Variation and 3D Genome‐Driven DNA/RNA Methylation Divergence Contributing to Cotton Fiber Domestication

Advanced Science, Volume 13, Issue 9, 13 February 2026.
These findings elucidated the crucial role of the “SVs‐3D genome remodeling‐epigenetic modifications‐gene expression” cascade regulatory network in cotton fiber domestication, offering both a theoretical foundation and genetic resources for molecular design breeding in fiber crops.
Lei Shao, Shangkun Jin, Haojie Jiang, Tianyu Pan, Zesheng Rui, Xiaowen Shi, Ting Zhao, Zhanfeng Si, Xueying Guan, Yan Hu, Tianzhen Zhang, Lei Fang   +11 more
wiley   +1 more source

Enhancing the heat tolerance of homolactic Escherichia coli through reverse metabolic engineering. [PDF]

Appl Microbiol Biotechnol
Pérez-Morales G, Vara-Coapango J, Merino E, Cevallos MA, Gosset G, Martinez A.   +5 more
europepmc   +1 more source

Genome‐Wide Association Analyses Reveal the Genetic Basis of EMS Mutagenesis Efficiency in Rice

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Based on large‐scale screening of 420 rice accessions, GWAS identified the Rc locus as a key regulator of EMS mutagenesis efficiency. Functional Rc alleles enhance both seed survival and genome‐wide mutation frequency by boosting antioxidant enzyme activities (CAT, SOD, POD) and reducing oxidative damage.
Peizhou Xu, Qinglu Zhang, Le Xue, Zhen Zhang, Nanhui Luo, Zhaoyang Cheng, Duo Xia, Shuqin Zheng, Xianjun Wu, Hao Zhou   +9 more
wiley   +1 more source

The epigenomic landscape of transposable elements across normal human development and anatomy [PDF]

, 2019
Choudhary, Mayank N.K., Pehrsson, Erica C., Sundaram, Vasavi, Wang, Ting   +3 more
core   +1 more source