ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian +8 more
wiley +1 more source
Effect of low-temperature stress on sperm DNA methylation and oxidative damage during cryopreservation of Tibetan pig semen. [PDF]
Duan M +5 more
europepmc +1 more source
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho +7 more
wiley +1 more source
Species-Discriminating Diagnostic PCR, Ribosomal Intergenic Spacer-Based Single-Marker Taxonomy and Cryptic Descriptions of the Fungal Entomopathogens <i>Metarhizium hybridum</i> and <i>Metarhizium parapingshaense</i>. [PDF]
Schuster C +7 more
europepmc +1 more source
Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy
Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu +5 more
wiley +1 more source
Comparative analysis of mitochondrial genomes in the Ceratocystidaceae reveals highly conserved gene organization despite substantial genome size variation. [PDF]
Viljoen A +3 more
europepmc +1 more source
RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li +3 more
wiley +1 more source
Predicting immune-related thyroiditis using polygenic risk scores in patients with advanced melanoma. [PDF]
Tarhini AA +11 more
europepmc +1 more source
Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen +6 more
wiley +1 more source
Integrative multi-omics analysis widens annotation and functional insights into long non-coding RNAs of Arabidopsis thaliana. [PDF]
Vivek AT +4 more
europepmc +1 more source

