Results 21 to 30 of about 117,531 (301)

The regulatory content of intergenic DNA shapes genome architecture [PDF]

Genome Biology, 2004
Factors affecting the organization and spacing of functionally unrelated genes in metazoan genomes are not well understood. Because of the vast size of a typical metazoan genome compared to known regulatory and protein-coding regions, functional DNA is generally considered to have a negligible impact on gene spacing and genome organization.
Craig E, Nelson, Bradley M, Hersh, Sean B, Carroll   +2 more
openaire   +2 more sources

Ubiquitous selective constraints in the Drosophila genome revealed by a genome-wide interspecies comparison [PDF]

, 2006
Non-coding DNA comprises ∼80% of the euchromatic portion of the Drosophila melanogaster genome. Non-coding sequences are known to contain functionally important elements controlling gene expression, but the proportion of sites that are selectively ...
Keightley, Peter, Halligan, Daniel
core   +1 more source

Next generation sequencing analysis reveals a relationship between rDNA unit diversity and locus number in Nicotiana diploids [PDF]

, 2012
Background Tandemly arranged nuclear ribosomal DNA (rDNA), encoding 18S, 5.8S and 26S ribosomal RNA (rRNA), exhibit concerted evolution, a pattern thought to result from the homogenisation of rDNA arrays. However rDNA homogeneity at the single nucleotide
Fulnecek, Jaroslav, Nichols, Richard, Simon Renny-Byfield, Macas Jiří, Kovařík Aleš, Aleš Kovařík, Kovarik, A, Grandbastien Marie-Angele, Andrew Leitch, Renny-Byfield Simon, Leitch Andrew, Kovarik, Ales, Roman Matyášek, Matyasek, R, Macas, Jiri, Macas, J, Richard Nichols, Renny-Byfield, Simon, Nichols Richard, Marie-Angele Grandbastien, Jaroslav Fulneček, Leitch, A, Grandbastien, Marie Angele, Leitch, Andrew, Renny-Byfield, S, Nichols, R, Jiří Macas, Matyášek Roman, Fulneček Jaroslav, Grandbastien, M-A, Fulnecek, J, Matyasek, Roman   +31 more
core   +1 more source

Conversion at Large Intergenic Regions of Mitochondrial DNA in Saccharomyces cerevisiae [PDF]

Molecular and Cellular Biology, 1990
Saccharomyces cerevisiae mitochondrial DNA deletion mutants have been used to examine whether base-biased intergenic regions of the genome influence mitochondrial biogenesis. One strain (delta 5.0) lacks a 5-kilobase (kb) segment extending from the proline tRNA gene to the small rRNA gene that includes ori1, while a second strain (delta 3.7) is missing
P J, Skelly, G D, Clark-Walker
openaire   +2 more sources

Parenting stress and DNA methylation among African Americans in the InterGEN Study [PDF]

Journal of Clinical and Translational Science, 2017
IntroductionGeneral life stress has been associated with altered DNA methylation in individuals of African Ancestry, although the relationship between parenting stress and DNA methylation has not been described. The purpose of this study was to examine the relationship between maternal parenting stress and DNA methylation among African Ancestry mother ...
Michelle L. Wright, Yunfeng Huang, Qin Hui, Kevin Newhall, Cindy Crusto, Yan V. Sun, Jacquelyn Y. Taylor   +6 more
openaire   +3 more sources

Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer. [PDF]

, 2015
BACKGROUND: Common genetic variants residing near upstream regulatory elements for MYB, the gene encoding transcription factor cMYB, promote the persistence of fetal hemoglobin (HbF) into adulthood. While they have no consequences in healthy individuals,
Soka, Deogratius, Harvest Mariki, Menzel, Stephan, Jeffrey C Barrett, Mariki, Harvest, Helen Rooks, Bruno Mmbando, Menzel, Stephan; id_orcid, Mmbando, Bruno, Tarjinder Singh, Stephan Menzel, Barrett, Jeffrey C., Sharon E Cox, Singh, Tarjinder, Mtatiro, Siana N, Barrett, Jeffrey C, Thein, Swee Lay, Deogratius Soka, Swee Lay Thein, Julie Makani, Mtatiro, Siana N., Siana N Mtatiro, Cox, Sharon E, Rooks, Helen, Mgaya, Josephine, Makani, Julie, Josephine Mgaya, Cox, Sharon E.   +27 more
core   +1 more source

DataSheet1_Non-coding regions of nuclear-DNA-encoded mitochondrial genes and intergenic sequences are targeted by autoantibodies in breast cancer.docx [PDF]

, 2023
Autoantibodies against mitochondrial-derived antigens play a key role in chronic tissue inflammation in autoimmune disorders and cancers. Here, we identify autoreactive nuclear genomic DNA (nDNA)-encoded mitochondrial gene products (GAPDH, PKM2, GSTP1 ...
Azadeh Stark (10721548), Marie-Claire Maroun (14853745), Félix Fernandez-Madrid (14853748), Roberta Giordo (299595), Rooshan Arshad (10054007), Leonard Lipovich (16637), Emilia Banisad (14853742), Erica L. Kleinbrink (3376157), Lawrence I. Grossman (14819504), Deya Obaidat (14853739)   +9 more
core   +1 more source

MCALIGN2: Faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution [PDF]

, 2006
Background Non-coding DNA sequences comprise a very large proportion of the total genomic content of mammals, most other vertebrates, many invertebrates, and most plants. Unraveling the functional significance of non-coding DNA depends on how well we are
Johnson Toby, Wang Jun, Johnson, Toby, Keightley Peter D, Keightley, Peter, Wang, Jun   +5 more
core   +1 more source

Identification and Characterization of an Intergenic “Safe Haven” Region in Human Fungal Pathogen Cryptococcus gattii

Journal of Fungi, 2022
Cryptococcus gattii is a primary fungal pathogen, which causes pulmonary and brain infections in healthy as well as immunocompromised individuals. Genetic manipulations in this pathogen are widely employed to study its biology and pathogenesis, and ...
Yeqi Li, Tuyetnhu Pham, Xiaofeng Xie, Xiaorong Lin   +3 more
doaj   +1 more source

Sigma: multiple alignment of weakly-conserved non-coding DNA sequence

BMC Bioinformatics, 2006
Background Existing tools for multiple-sequence alignment focus on aligning protein sequence or protein-coding DNA sequence, and are often based on extensions to Needleman-Wunsch-like pairwise alignment methods. We introduce a new tool, Sigma, with a new
Siddharthan Rahul
doaj   +1 more source