Results 31 to 40 of about 117,531 (301)
A comprehensive genome-wide map of autonomously replicating sequences in a naive genome. [PDF]
PLoS Genetics, 2010 Eukaryotic chromosomes initiate DNA synthesis from multiple replication origins. The machinery that initiates DNA synthesis is highly conserved, but the sites where the replication initiation proteins bind have diverged significantly.
Ivan Liachko +5 more
doaj +1 more source
Frontiers in Oncology, 2023 Non-small cell lung cancers (NSCLCs) with anaplastic lymphoma kinase (ALK)-rearrangement have favorable responses to ALK inhibitors. However, ALK fusion mutations harbored approximately 90 distinct fusion partners.
Lingxin Yan +5 more
doaj +1 more source
Bent DNA in the Large Intergenic Region of Wheat Dwarf Geminivirus
Virology, 1995 Wheat dwarf virus (WDV) is a member of the geminivirus group, unique plant DNA viruses which replicate exclusively via dsDNA replication intermediates. The large intergenic region (LIR), a nontranscribed regulatory region, contains an inverted repeat with the potential to form a stem-loop structure in which the initiation site for WDV (+)strand (virion-
Suärez-López, Paula +3 more
openaire +2 more sources
Examples of intergenic HPV16 DNA integration sites. [PDF]
, 2013 (A) Tumor T3966 has one transcriptionally active HPV16 integration site 3966_DJ1 (TA-group 1), which is located between the cellular genes RASSF6 and IL8, and has the same orientation as the downstream gene IL8.
Elisabeth Schwarz (83829) +6 more
core +1 more source
BMC Plant Biology, 2018 Background The grass family (Poaceae), ca. 12,075 species, is a focal point of many recent studies that aim to use complete plastomes to reveal and strengthen relationships within the family.
Sean V. Burke +2 more
doaj +1 more source
Intergenic and Intronic DNA Hypomethylated Regions as Putative Regulators of Imprinted Domains [PDF]
Epigenomics, 2018 To investigate the regulatory potential of intergenic/intronic hypomethylated regions (iHMRs) within imprinted domains.Based on the preliminary results of the histone modification and conservation profiles, we conducted reporter assays on the Peg3 and H19 domain iHMRs. The in vitro results were confirmed by the in vivo deletion of Peg3-iHMR designed to
Arundhati, Bakshi +3 more
openaire +2 more sources
An investigation of horizontal transfer of feed introduced DNA to the aerobic microbiota of the gastrointestinal tract of rats [PDF]
, 2012 BACKGROUND: Horizontal gene transfer through natural transformation of members of the microbiota of the lower gastrointestinal tract (GIT) of mammals has not yet been described.
Raddadi Noura +22 more
core +1 more source
The DNMT1-associated lincRNA DACOR1 reprograms genome-wide DNA methylation in colon cancer
Clinical Epigenetics, 2018 Background DNA methylation is a key epigenetic mark in mammalian organisms that plays key roles in chromatin organization and gene expression. Although DNA methylation in gene promoters is generally associated with gene repression, recent studies ...
Saigopal Somasundaram +7 more
doaj +1 more source
CtBP levels control intergenic transcripts, PHO/YY1 DNA binding, and PcG recruitment to DNA [PDF]
Journal of Cellular Biochemistry, 2010 AbstractCarboxy‐terminal binding protein (CtBP) is a well‐known corepressor of several DNA binding transcription factors in Drosophila as well as in mammals. CtBP is implicated in Polycomb Group (PcG) complex‐mediated transcriptional repression because it can bind to some PcG proteins, and mutation of the ctbp gene in flies results in lost PcG protein ...
Arindam, Basu, Michael L, Atchison
openaire +2 more sources
BMC Genomics, 2011 Background DNA methylation has been linked to genome regulation and dysregulation in health and disease respectively, and methods for characterizing genomic DNA methylation patterns are rapidly emerging.
De Marzo Angelo M +12 more
doaj +1 more source