Results 31 to 40 of about 171,193 (280)
Conversion at Large Intergenic Regions of Mitochondrial DNA in Saccharomyces cerevisiae [PDF]
Molecular and Cellular Biology, 1990 Saccharomyces cerevisiae mitochondrial DNA deletion mutants have been used to examine whether base-biased intergenic regions of the genome influence mitochondrial biogenesis. One strain (delta 5.0) lacks a 5-kilobase (kb) segment extending from the proline tRNA gene to the small rRNA gene that includes ori1, while a second strain (delta 3.7) is missing
P J, Skelly, G D, Clark-Walker
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Sigma: multiple alignment of weakly-conserved non-coding DNA sequence
BMC Bioinformatics, 2006 Background Existing tools for multiple-sequence alignment focus on aligning protein sequence or protein-coding DNA sequence, and are often based on extensions to Needleman-Wunsch-like pairwise alignment methods. We introduce a new tool, Sigma, with a new
Siddharthan Rahul
doaj +1 more source
Frontiers in Oncology, 2023 Non-small cell lung cancers (NSCLCs) with anaplastic lymphoma kinase (ALK)-rearrangement have favorable responses to ALK inhibitors. However, ALK fusion mutations harbored approximately 90 distinct fusion partners.
Lingxin Yan +5 more
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De novo DNA demethylation and noncoding transcription define active intergenic regulatory elements [PDF]
Genome Research, 2013 Deep sequencing of mammalian DNA methylomes has uncovered a previously unpredicted number of discrete hypomethylated regions in intergenic space (iHMRs). Here, we combined whole-genome bisulfite sequencing data with extensive gene expression and chromatin-state data to define functional classes of iHMRs, and to reconstruct the dynamics of their ...
Schlesinger, Felix +4 more
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A comprehensive genome-wide map of autonomously replicating sequences in a naive genome. [PDF]
PLoS Genetics, 2010 Eukaryotic chromosomes initiate DNA synthesis from multiple replication origins. The machinery that initiates DNA synthesis is highly conserved, but the sites where the replication initiation proteins bind have diverged significantly.
Ivan Liachko +5 more
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BMC Plant Biology, 2018 Background The grass family (Poaceae), ca. 12,075 species, is a focal point of many recent studies that aim to use complete plastomes to reveal and strengthen relationships within the family.
Sean V. Burke +2 more
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Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain [PDF]
, 2011 Objectives: The thickness of the brain’s cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated
Anderson eWinkler +18 more
core +5 more sources
Bent DNA in the Large Intergenic Region of Wheat Dwarf Geminivirus
Virology, 1995 Wheat dwarf virus (WDV) is a member of the geminivirus group, unique plant DNA viruses which replicate exclusively via dsDNA replication intermediates. The large intergenic region (LIR), a nontranscribed regulatory region, contains an inverted repeat with the potential to form a stem-loop structure in which the initiation site for WDV (+)strand (virion-
Suärez-López, Paula +3 more
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A global function for transcription factors in assisting RNA polymerase II termination. [PDF]
, 2017 The role of transcription factors (TFs) on nucleosome positioning, RNA polymerase recruitment, and transcription initiation has been extensively characterized.
Chanfreau, Guillaume F, Roy, Kevin
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Intergenic and Intronic DNA Hypomethylated Regions as Putative Regulators of Imprinted Domains [PDF]
Epigenomics, 2018 To investigate the regulatory potential of intergenic/intronic hypomethylated regions (iHMRs) within imprinted domains.Based on the preliminary results of the histone modification and conservation profiles, we conducted reporter assays on the Peg3 and H19 domain iHMRs. The in vitro results were confirmed by the in vivo deletion of Peg3-iHMR designed to
Arundhati, Bakshi +3 more
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