Results 121 to 130 of about 3,128,275 (354)

Quantifying engineered nanomaterial toxicity: comparison of common cytotoxicity and gene expression measurements [PDF]

, 2017
BACKGROUND: When evaluating the toxicity of engineered nanomaterials (ENMS) it is important to use multiple bioassays based on different mechanisms of action.
Atha, Donald H., Dennis, Allison M., Dua, Varsha, Hollingsworth, Jennifer A., Iyer, Rashi, Nagy, Amber, Nelson, Bryant C., Steinbrück, Andrea   +7 more
core   +2 more sources

Analysis of whole mitogenomes from ancient samples [PDF]

arXiv, 2015
Ancient mitochondrial DNA has been used in a wide variety of palaeontological and archaeological studies, ranging from population dynamics of extinct species to patterns of domestication. Most of these studies have traditionally been based on the analysis of short fragments from the mitochondrial control region, analysed using PCR coupled with Sanger ...
arxiv  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Circular DNA's from HeLa cell nuclei and mitochondria [PDF]

, 1970
An electron microscopic observation was made on the DNA's extracted from purified HeLa cell nuclei, mitochondria, and the whole cell, and fractionated by ethidium bromide-cesium chloride density gradient method or sucrose density gradient method. Nuclear
Hirata, Seiichi, Nishida, Shigeru, Oda, Takuzo, Omura, Sachiko, Yamamoto, Shinichiro   +4 more
core   +1 more source

Biparental Inheritance of Mitochondrial DNA in Humans

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The energy-producing organelle mitochondrion contains its own compact genome, which is separate from the nuclear genome. In nearly all mammals, this mitochondrial genome is inherited exclusively from the mother, and transmission of paternal ...
S. Luo, C. A. Valencia, Jinglan Zhang, Ni‐Chung Lee, J. Slone, B. Gui, Xinjian Wang, Zhuo Li, Sarah Dell, Jenice Brown, S. Chen, Y. Chien, W. Hwu, P. Fan, L. Wong, P. Atwal, Taosheng Huang   +16 more
semanticscholar   +1 more source

Mapping the Space of Genomic Signatures [PDF]

, 2014
We propose a computational method to measure and visualize interrelationships among any number of DNA sequences allowing, for example, the examination of hundreds or thousands of complete mitochondrial genomes. An "image distance" is computed for each pair of graphical representations of DNA sequences, and the distances are visualized as a Molecular ...
arxiv   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

A Monomer-to-Trimer Transition of the Human Mitochondrial Transcription Termination Factor (mTERF) Is Associated with a Loss of in Vitro Activity [PDF]

, 2004
The human mitochondrial transcription termination factor (mTERF) is a nuclear-encoded 39-kDa protein that recognizes a mtDNA segment within the mitochondrial tRNALeu(UUR) gene immediately adjacent to and downstream of the 16 S rRNA gene. Binding of mTERF
Asin-Cayuela, Jordi, Attardi, Giuseppe, Helm, Mark   +2 more
core   +1 more source

Mitochondrial DNA: Epigenetics and environment

Environmental and Molecular Mutagenesis, 2019
Maintenance of the mitochondrial genome is essential for proper cellular function. For this purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed, translated, and repaired in the face of constant onslaught from endogenous and ...
Nidhi Sharma, Monica S. Pasala, Aishwarya Prakash   +2 more
semanticscholar   +1 more source

Isolation and analysis of high quality nuclear DNA with reduced organellar DNA for plant genome sequencing and resequencing

BMC Biotechnology, 2011
Background High throughput sequencing (HTS) technologies have revolutionized the field of genomics by drastically reducing the cost of sequencing, making it feasible for individual labs to sequence or resequence plant genomes.
Zdepski Anna, Wang Wenqin, Lutz Kerry A, Michael Todd P   +3 more
doaj   +1 more source